Within-host microevolution of Streptococcus pneumoniae is rapid and adaptive during natural colonisation

Genomic evolution, transmission and pathogenesis of Streptococcus pneumoniae , an opportunistic human-adapted pathogen, is driven principally by nasopharyngeal carriage. However, little is known about genomic changes during natural colonisation. Here, we use whole-genome sequencing to investigate wi...

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Bibliographic Details
Published in:	Nature communications Vol. 11; no. 1; pp. 3442 - 14
Main Authors:	Chaguza, Chrispin, Senghore, Madikay, Bojang, Ebrima, Gladstone, Rebecca A., Lo, Stephanie W., Tientcheu, Peggy-Estelle, Bancroft, Rowan E., Worwui, Archibald, Foster-Nyarko, Ebenezer, Ceesay, Fatima, Okoi, Catherine, McGee, Lesley, Klugman, Keith P., Breiman, Robert F., Barer, Michael R., Adegbola, Richard A., Antonio, Martin, Bentley, Stephen D., Kwambana-Adams, Brenda A.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 10.07.2020 Nature Publishing Group Nature Portfolio
Subjects:	13 45 45/23 631/208/212/2304 631/208/325/2482 631/326/107 692/308/3187 Antibiotic resistance Antibiotics Colonization Divergence Drug resistance Evolution Evolution, Molecular Evolutionary genetics Gene sequencing Genetic diversity Genetics Genome, Bacterial - genetics Genomes Genomics Homologous recombination Homology Humanities and Social Sciences Humans Infants multidisciplinary Nucleotides Opportunist infection Pathogenesis Pathogens Pneumococcal Infections - genetics Science Science (multidisciplinary) Streptococcus infections Streptococcus pneumoniae Streptococcus pneumoniae - genetics Substitutes Whole Genome Sequencing
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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