Childhood body size directly increases type 1 diabetes risk based on a lifecourse Mendelian randomization approach

The rising prevalence of childhood obesity has been postulated as an explanation for the increasing rate of individuals diagnosed with type 1 diabetes (T1D). In this study, we use Mendelian randomization (MR) to provide evidence that childhood body size has an effect on T1D risk (OR = 2.05 per chang...

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Bibliographic Details
Published in:	Nature communications Vol. 13; no. 1; pp. 2337 - 9
Main Authors:	Richardson, Tom G., Crouch, Daniel J. M., Power, Grace M., Morales-Berstein, Fernanda, Hazelwood, Emma, Fang, Si, Cho, Yoonsu, Inshaw, Jamie R. J., Robertson, Catherine C., Sidore, Carlo, Cucca, Francesco, Rich, Steven S., Todd, John A., Davey Smith, George
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 28.04.2022 Nature Publishing Group Nature Portfolio
Subjects:	45/43 692/308/174 692/308/3187 692/499 692/699/249/1313/1418 Adult Asthma Body Size Body weight Child Childhood Children Diabetes Diabetes mellitus (insulin dependent) Diabetes Mellitus, Type 1 - epidemiology Diabetes Mellitus, Type 1 - genetics Eczema Health risks Humanities and Social Sciences Humans Hypothyroidism Infant, Newborn Mendelian Randomization Analysis multidisciplinary Obesity Overweight Overweight - complications Pediatric Obesity - complications Pediatric Obesity - epidemiology Pediatric Obesity - genetics Randomization Risk Science Science (multidisciplinary) Skin diseases
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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