Effects of Apolipoprotein E polymorphism on carotid intima-media thickness, incident myocardial infarction and incident stroke

The Apolipoprotein E (APOE) gene polymorphism (rs429358 and rs7412) shows a well-established association with lipid profiles, but its effect on cardiovascular disease is still conflicting. Therefore, we examined the association of different APOE alleles with common carotid artery intima-media thickn...

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Bibliographic Details
Published in:Scientific reports Vol. 12; no. 1; pp. 5142 - 10
Main Authors: Pitchika, Anitha, Markus, Marcello Ricardo Paulista, Schipf, Sabine, Teumer, Alexander, Van der Auwera, Sandra, Nauck, Matthias, Dörr, Marcus, Felix, Stephan, Grabe, Hans-Jörgen, Völzke, Henry, Ittermann, Till
Format: Journal Article
Language:English
Published: London Nature Publishing Group UK 24.03.2022
Nature Publishing Group
Nature Portfolio
Subjects:
692/4019
692/499
Alleles
Apolipoprotein E4
Apolipoproteins
Apolipoproteins E - genetics
Cardiovascular diseases
Carotid artery
Carotid Intima-Media Thickness
Cerebral infarction
Gene polymorphism
Heart attacks
Homozygotes
Humanities and Social Sciences
Humans
multidisciplinary
Myocardial infarction
Myocardial Infarction - epidemiology
Myocardial Infarction - genetics
Plaque, Atherosclerotic
Plaques
Polymorphism
Polymorphism, Genetic
Population studies
Regression analysis
Risk Factors
Science
Science (multidisciplinary)
Stroke
Stroke - epidemiology
Stroke - genetics
ISSN:2045-2322, 2045-2322
Online Access:Get full text
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Summary:The Apolipoprotein E (APOE) gene polymorphism (rs429358 and rs7412) shows a well-established association with lipid profiles, but its effect on cardiovascular disease is still conflicting. Therefore, we examined the association of different APOE alleles with common carotid artery intima-media thickness (CCA-IMT), carotid plaques, incident myocardial infarction (MI) and stroke. We analyzed data from 3327 participants aged 20–79 years of the population-based Study of Health in Pomerania (SHIP) from Northeast Germany with a median follow-up time of 14.5 years. Linear, logistic, and Cox-regression models were used to assess the associations of the APOE polymorphism with CCA-IMT, carotid plaques, incident MI and stroke, respectively. In our study, the APOE E2 allele was associated with lower CCA-IMT at baseline compared to E3 homozygotes (β: − 0.02 [95% CI − 0.04, − 0.004]). Over the follow-up, 244 MI events and 218 stroke events were observed. APOE E2 and E4 allele were not associated with incident MI (E2 HR: 1.06 [95% CI 0.68, 1.66]; E4 HR: 1.03 [95% CI 0.73, 1.45]) and incident stroke (E2 HR: 0.79 [95% CI 0.48, 1.30]; E4 HR: 0.96 [95% CI 0.66, 1.38]) in any of the models adjusting for potential confounders. However, the positive association between CCA-IMT and incident MI was more pronounced in E2 carriers than E3 homozygotes. Thus, our study suggests that while APOE E2 allele may predispose individuals to lower CCA-IMT, E2 carriers may be more prone to MI than E3 homozygotes as the CCA-IMT increases. APOE E4 allele had no effect on CCA-IMT, plaques, MI or stroke.
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ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-022-09129-5