Effects of Apolipoprotein E polymorphism on carotid intima-media thickness, incident myocardial infarction and incident stroke
The Apolipoprotein E (APOE) gene polymorphism (rs429358 and rs7412) shows a well-established association with lipid profiles, but its effect on cardiovascular disease is still conflicting. Therefore, we examined the association of different APOE alleles with common carotid artery intima-media thickn...
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| Veröffentlicht in: | Scientific reports Jg. 12; H. 1; S. 5142 - 10 |
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| Abstract | The Apolipoprotein E (APOE) gene polymorphism (rs429358 and rs7412) shows a well-established association with lipid profiles, but its effect on cardiovascular disease is still conflicting. Therefore, we examined the association of different APOE alleles with common carotid artery intima-media thickness (CCA-IMT), carotid plaques, incident myocardial infarction (MI) and stroke. We analyzed data from 3327 participants aged 20–79 years of the population-based Study of Health in Pomerania (SHIP) from Northeast Germany with a median follow-up time of 14.5 years. Linear, logistic, and Cox-regression models were used to assess the associations of the APOE polymorphism with CCA-IMT, carotid plaques, incident MI and stroke, respectively. In our study, the APOE E2 allele was associated with lower CCA-IMT at baseline compared to E3 homozygotes (β: − 0.02 [95% CI − 0.04, − 0.004]). Over the follow-up, 244 MI events and 218 stroke events were observed. APOE E2 and E4 allele were not associated with incident MI (E2 HR: 1.06 [95% CI 0.68, 1.66]; E4 HR: 1.03 [95% CI 0.73, 1.45]) and incident stroke (E2 HR: 0.79 [95% CI 0.48, 1.30]; E4 HR: 0.96 [95% CI 0.66, 1.38]) in any of the models adjusting for potential confounders. However, the positive association between CCA-IMT and incident MI was more pronounced in E2 carriers than E3 homozygotes. Thus, our study suggests that while APOE E2 allele may predispose individuals to lower CCA-IMT, E2 carriers may be more prone to MI than E3 homozygotes as the CCA-IMT increases. APOE E4 allele had no effect on CCA-IMT, plaques, MI or stroke. |
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| AbstractList | The Apolipoprotein E (APOE) gene polymorphism (rs429358 and rs7412) shows a well-established association with lipid profiles, but its effect on cardiovascular disease is still conflicting. Therefore, we examined the association of different APOE alleles with common carotid artery intima-media thickness (CCA-IMT), carotid plaques, incident myocardial infarction (MI) and stroke. We analyzed data from 3327 participants aged 20-79 years of the population-based Study of Health in Pomerania (SHIP) from Northeast Germany with a median follow-up time of 14.5 years. Linear, logistic, and Cox-regression models were used to assess the associations of the APOE polymorphism with CCA-IMT, carotid plaques, incident MI and stroke, respectively. In our study, the APOE E2 allele was associated with lower CCA-IMT at baseline compared to E3 homozygotes (β: - 0.02 [95% CI - 0.04, - 0.004]). Over the follow-up, 244 MI events and 218 stroke events were observed. APOE E2 and E4 allele were not associated with incident MI (E2 HR: 1.06 [95% CI 0.68, 1.66]; E4 HR: 1.03 [95% CI 0.73, 1.45]) and incident stroke (E2 HR: 0.79 [95% CI 0.48, 1.30]; E4 HR: 0.96 [95% CI 0.66, 1.38]) in any of the models adjusting for potential confounders. However, the positive association between CCA-IMT and incident MI was more pronounced in E2 carriers than E3 homozygotes. Thus, our study suggests that while APOE E2 allele may predispose individuals to lower CCA-IMT, E2 carriers may be more prone to MI than E3 homozygotes as the CCA-IMT increases. APOE E4 allele had no effect on CCA-IMT, plaques, MI or stroke. The Apolipoprotein E (APOE) gene polymorphism (rs429358 and rs7412) shows a well-established association with lipid profiles, but its effect on cardiovascular disease is still conflicting. Therefore, we examined the association of different APOE alleles with common carotid artery intima-media thickness (CCA-IMT), carotid plaques, incident myocardial infarction (MI) and stroke. We analyzed data from 3327 participants aged 20–79 years of the population-based Study of Health in Pomerania (SHIP) from Northeast Germany with a median follow-up time of 14.5 years. Linear, logistic, and Cox-regression models were used to assess the associations of the APOE polymorphism with CCA-IMT, carotid plaques, incident MI and stroke, respectively. In our study, the APOE E2 allele was associated with lower CCA-IMT at baseline compared to E3 homozygotes (β: − 0.02 [95% CI − 0.04, − 0.004]). Over the follow-up, 244 MI events and 218 stroke events were observed. APOE E2 and E4 allele were not associated with incident MI (E2 HR: 1.06 [95% CI 0.68, 1.66]; E4 HR: 1.03 [95% CI 0.73, 1.45]) and incident stroke (E2 HR: 0.79 [95% CI 0.48, 1.30]; E4 HR: 0.96 [95% CI 0.66, 1.38]) in any of the models adjusting for potential confounders. However, the positive association between CCA-IMT and incident MI was more pronounced in E2 carriers than E3 homozygotes. Thus, our study suggests that while APOE E2 allele may predispose individuals to lower CCA-IMT, E2 carriers may be more prone to MI than E3 homozygotes as the CCA-IMT increases. APOE E4 allele had no effect on CCA-IMT, plaques, MI or stroke. The Apolipoprotein E (APOE) gene polymorphism (rs429358 and rs7412) shows a well-established association with lipid profiles, but its effect on cardiovascular disease is still conflicting. Therefore, we examined the association of different APOE alleles with common carotid artery intima-media thickness (CCA-IMT), carotid plaques, incident myocardial infarction (MI) and stroke. We analyzed data from 3327 participants aged 20-79 years of the population-based Study of Health in Pomerania (SHIP) from Northeast Germany with a median follow-up time of 14.5 years. Linear, logistic, and Cox-regression models were used to assess the associations of the APOE polymorphism with CCA-IMT, carotid plaques, incident MI and stroke, respectively. In our study, the APOE E2 allele was associated with lower CCA-IMT at baseline compared to E3 homozygotes (β: - 0.02 [95% CI - 0.04, - 0.004]). Over the follow-up, 244 MI events and 218 stroke events were observed. APOE E2 and E4 allele were not associated with incident MI (E2 HR: 1.06 [95% CI 0.68, 1.66]; E4 HR: 1.03 [95% CI 0.73, 1.45]) and incident stroke (E2 HR: 0.79 [95% CI 0.48, 1.30]; E4 HR: 0.96 [95% CI 0.66, 1.38]) in any of the models adjusting for potential confounders. However, the positive association between CCA-IMT and incident MI was more pronounced in E2 carriers than E3 homozygotes. Thus, our study suggests that while APOE E2 allele may predispose individuals to lower CCA-IMT, E2 carriers may be more prone to MI than E3 homozygotes as the CCA-IMT increases. APOE E4 allele had no effect on CCA-IMT, plaques, MI or stroke.The Apolipoprotein E (APOE) gene polymorphism (rs429358 and rs7412) shows a well-established association with lipid profiles, but its effect on cardiovascular disease is still conflicting. Therefore, we examined the association of different APOE alleles with common carotid artery intima-media thickness (CCA-IMT), carotid plaques, incident myocardial infarction (MI) and stroke. We analyzed data from 3327 participants aged 20-79 years of the population-based Study of Health in Pomerania (SHIP) from Northeast Germany with a median follow-up time of 14.5 years. Linear, logistic, and Cox-regression models were used to assess the associations of the APOE polymorphism with CCA-IMT, carotid plaques, incident MI and stroke, respectively. In our study, the APOE E2 allele was associated with lower CCA-IMT at baseline compared to E3 homozygotes (β: - 0.02 [95% CI - 0.04, - 0.004]). Over the follow-up, 244 MI events and 218 stroke events were observed. APOE E2 and E4 allele were not associated with incident MI (E2 HR: 1.06 [95% CI 0.68, 1.66]; E4 HR: 1.03 [95% CI 0.73, 1.45]) and incident stroke (E2 HR: 0.79 [95% CI 0.48, 1.30]; E4 HR: 0.96 [95% CI 0.66, 1.38]) in any of the models adjusting for potential confounders. However, the positive association between CCA-IMT and incident MI was more pronounced in E2 carriers than E3 homozygotes. Thus, our study suggests that while APOE E2 allele may predispose individuals to lower CCA-IMT, E2 carriers may be more prone to MI than E3 homozygotes as the CCA-IMT increases. APOE E4 allele had no effect on CCA-IMT, plaques, MI or stroke. The Apolipoprotein E (APOE) gene polymorphism (rs429358 and rs7412) shows a well-established association with lipid profiles, but its effect on cardiovascular disease is still conflicting. Therefore, we examined the association of different APOE alleles with common carotid artery intima-media thickness (CCA-IMT), carotid plaques, incident myocardial infarction (MI) and stroke. We analyzed data from 3327 participants aged 20–79 years of the population-based Study of Health in Pomerania (SHIP) from Northeast Germany with a median follow-up time of 14.5 years. Linear, logistic, and Cox-regression models were used to assess the associations of the APOE polymorphism with CCA-IMT, carotid plaques, incident MI and stroke, respectively. In our study, the APOE E2 allele was associated with lower CCA-IMT at baseline compared to E3 homozygotes (β: − 0.02 [95% CI − 0.04, − 0.004]). Over the follow-up, 244 MI events and 218 stroke events were observed. APOE E2 and E4 allele were not associated with incident MI (E2 HR: 1.06 [95% CI 0.68, 1.66]; E4 HR: 1.03 [95% CI 0.73, 1.45]) and incident stroke (E2 HR: 0.79 [95% CI 0.48, 1.30]; E4 HR: 0.96 [95% CI 0.66, 1.38]) in any of the models adjusting for potential confounders. However, the positive association between CCA-IMT and incident MI was more pronounced in E2 carriers than E3 homozygotes. Thus, our study suggests that while APOE E2 allele may predispose individuals to lower CCA-IMT, E2 carriers may be more prone to MI than E3 homozygotes as the CCA-IMT increases. APOE E4 allele had no effect on CCA-IMT, plaques, MI or stroke. Abstract The Apolipoprotein E (APOE) gene polymorphism (rs429358 and rs7412) shows a well-established association with lipid profiles, but its effect on cardiovascular disease is still conflicting. Therefore, we examined the association of different APOE alleles with common carotid artery intima-media thickness (CCA-IMT), carotid plaques, incident myocardial infarction (MI) and stroke. We analyzed data from 3327 participants aged 20–79 years of the population-based Study of Health in Pomerania (SHIP) from Northeast Germany with a median follow-up time of 14.5 years. Linear, logistic, and Cox-regression models were used to assess the associations of the APOE polymorphism with CCA-IMT, carotid plaques, incident MI and stroke, respectively. In our study, the APOE E2 allele was associated with lower CCA-IMT at baseline compared to E3 homozygotes (β: − 0.02 [95% CI − 0.04, − 0.004]). Over the follow-up, 244 MI events and 218 stroke events were observed. APOE E2 and E4 allele were not associated with incident MI (E2 HR: 1.06 [95% CI 0.68, 1.66]; E4 HR: 1.03 [95% CI 0.73, 1.45]) and incident stroke (E2 HR: 0.79 [95% CI 0.48, 1.30]; E4 HR: 0.96 [95% CI 0.66, 1.38]) in any of the models adjusting for potential confounders. However, the positive association between CCA-IMT and incident MI was more pronounced in E2 carriers than E3 homozygotes. Thus, our study suggests that while APOE E2 allele may predispose individuals to lower CCA-IMT, E2 carriers may be more prone to MI than E3 homozygotes as the CCA-IMT increases. APOE E4 allele had no effect on CCA-IMT, plaques, MI or stroke. |
| ArticleNumber | 5142 |
| Author | Grabe, Hans-Jörgen Van der Auwera, Sandra Markus, Marcello Ricardo Paulista Teumer, Alexander Schipf, Sabine Völzke, Henry Dörr, Marcus Pitchika, Anitha Nauck, Matthias Ittermann, Till Felix, Stephan |
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| Cites_doi | 10.1016/j.fob.2015.10.006 10.1161/01.STR.28.12.2410 10.1161/01.STR.0000062901.54157.12 10.1177/1074248416686187 10.1016/S0021-9150(00)00383-X 10.1016/j.diabres.2022.109778 10.1016/j.ebiom.2020.102954 10.1093/ije/dyt034 10.1161/JAHA.116.005313 10.1001/jamaneurol.2017.2188 10.1212/01.WNL.0000118302.66674.E1 10.1007/BF01324255 10.1179/1743132814Y.0000000385 10.1007/s00702-013-1019-8 10.1007/s00109-016-1427-y 10.1016/j.atherosclerosis.2020.09.015 10.1161/01.STR.31.6.1299 10.1038/s41598-021-88256-x 10.1185/030079902125000444 10.1161/STROKEAHA.107.488866 10.1161/hs0901.095377 10.1161/01.STR.0000185687.28520.3f 10.1016/j.atherosclerosis.2015.01.030 10.1371/journal.pone.0104608 10.1161/STROKEAHA.107.487264 10.1046/j.1365-2362.2001.00851.x 10.1161/STROKEAHA.112.673129 10.1016/j.jstrokecerebrovasdis.2017.09.053 10.1111/j.1538-7836.2005.01440.x 10.1161/01.ATV.15.9.1280 10.3174/ajnr.A4805 10.7326/0003-4819-141-2-200407200-00013 10.1161/CIRCULATIONAHA.120.046361 10.1194/jlr.M400114-JLR200 10.1155/2016/3912175 10.1016/j.numecd.2007.01.003 10.1016/j.jstrokecerebrovasdis.2017.05.048 10.1016/j.atherosclerosis.2012.09.026 10.1186/s12947-015-0041-4 10.1161/01.STR.27.8.1310 10.1161/01.CIR.0000133440.86427.26 10.1093/ije/dyp394 10.1161/01.STR.29.9.1882 10.1016/S0021-9150(02)00335-0 10.1038/s41598-019-54285-w 10.1161/CIRCGENETICS.116.001572 10.1016/j.atherosclerosis.2016.01.009 |
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| References | Øygarden (CR28) 2017; 6 Habes (CR33) 2016; 37 Khan (CR13) 2013; 42 Song, Stampfer, Liu (CR43) 2004; 141 Gibbons (CR2) 2004; 109 Slooter (CR15) 2004; 62 Granér (CR37) 2008; 18 MacLeod (CR17) 2001; 31 Wang (CR5) 2013; 120 Li (CR4) 2021; 11 Slooter (CR21) 2001; 32 Mahley (CR8) 2016; 94 Kolovou (CR14) 2002; 18 Sirimarco (CR27) 2013; 44 Sherling, Perumareddi, Hennekens (CR1) 2017; 22 Tosetto (CR34) 2005; 3 Kuusisto (CR47) 1995; 15 John (CR31) 2001; 46 Qu, Qu (CR38) 2015; 13 Wei (CR10) 2017; 26 Willeit (CR26) 2020; 142 Sturgeon (CR19) 2005; 36 Liu (CR39) 2019; 9 Völzke (CR30) 2011; 40 Pitchika (CR42) 2022; 2022 Natarajan (CR20) 2016; 9 Raggi, Stein (CR25) 2020; 312 Paternoster (CR22) 2008; 39 Ilveskoski (CR35) 2000; 153 Elosua (CR36) 2004; 45 Ferrucci (CR18) 1997; 28 Johnsen (CR29) 2007; 38 Xu (CR9) 2014; 9 Blazejewska-Hyzorek (CR12) 2014; 36 McCarron (CR48) 1998; 29 Liu (CR16) 2003; 166 CR45 Rosvall (CR40) 2015; 239 Chen (CR6) 2019; 32 Doliner (CR23) 2018; 27 Xu (CR44) 2016; 2016 Troitzsch (CR32) 2012; 225 Basun (CR46) 1996; 27 Kokubo (CR11) 2000; 31 Beilby (CR24) 2003; 34 Lumsden (CR41) 2020; 59 Wang (CR3) 2015; 5 Neu (CR7) 2017; 74 M Li (9129_CR4) 2021; 11 L Ferrucci (9129_CR18) 1997; 28 B Doliner (9129_CR23) 2018; 27 Y Liu (9129_CR39) 2019; 9 Y-L Wang (9129_CR3) 2015; 5 S Liu (9129_CR16) 2003; 166 A Pitchika (9129_CR42) 2022; 2022 SC Neu (9129_CR7) 2017; 74 J Kuusisto (9129_CR47) 1995; 15 M Xu (9129_CR44) 2016; 2016 TA Khan (9129_CR13) 2013; 42 H Øygarden (9129_CR28) 2017; 6 P Natarajan (9129_CR20) 2016; 9 AJC Slooter (9129_CR21) 2001; 32 JD Sturgeon (9129_CR19) 2005; 36 H Basun (9129_CR46) 1996; 27 P Raggi (9129_CR25) 2020; 312 G Sirimarco (9129_CR27) 2013; 44 SH Johnsen (9129_CR29) 2007; 38 P Troitzsch (9129_CR32) 2012; 225 E Ilveskoski (9129_CR35) 2000; 153 G Kolovou (9129_CR14) 2002; 18 A Tosetto (9129_CR34) 2005; 3 M Rosvall (9129_CR40) 2015; 239 L Paternoster (9129_CR22) 2008; 39 GH Gibbons (9129_CR2) 2004; 109 B Blazejewska-Hyzorek (9129_CR12) 2014; 36 AL Lumsden (9129_CR41) 2020; 59 U John (9129_CR31) 2001; 46 M Habes (9129_CR33) 2016; 37 MO McCarron (9129_CR48) 1998; 29 MJ MacLeod (9129_CR17) 2001; 31 M Granér (9129_CR37) 2008; 18 JP Beilby (9129_CR24) 2003; 34 P Willeit (9129_CR26) 2020; 142 H Völzke (9129_CR30) 2011; 40 Q-Y Wang (9129_CR5) 2013; 120 DW Chen (9129_CR6) 2019; 32 H Xu (9129_CR9) 2014; 9 R Elosua (9129_CR36) 2004; 45 RW Mahley (9129_CR8) 2016; 94 DH Sherling (9129_CR1) 2017; 22 Y Song (9129_CR43) 2004; 141 9129_CR45 LK Wei (9129_CR10) 2017; 26 B Qu (9129_CR38) 2015; 13 Y Kokubo (9129_CR11) 2000; 31 AJC Slooter (9129_CR15) 2004; 62 |
| References_xml | – volume: 5 start-page: 852 year: 2015 end-page: 858 ident: CR3 article-title: Association between Apolipoprotein E polymorphism and myocardial infarction risk: A systematic review and meta-analysis publication-title: FEBS Open Bio doi: 10.1016/j.fob.2015.10.006 – volume: 28 start-page: 2410 issue: 12 year: 1997 end-page: 2416 ident: CR18 article-title: 2 allele and risk of stroke in the older population publication-title: Stroke doi: 10.1161/01.STR.28.12.2410 – volume: 34 start-page: 869 issue: 4 year: 2003 end-page: 874 ident: CR24 article-title: Apolipoprotein E gene polymorphisms are associated with carotid plaque formation but not with intima-media wall thickening publication-title: Stroke doi: 10.1161/01.STR.0000062901.54157.12 – ident: CR45 – volume: 22 start-page: 365 issue: 4 year: 2017 end-page: 367 ident: CR1 article-title: Metabolic syndrome publication-title: J. Cardiovasc. Pharmacol. Ther. doi: 10.1177/1074248416686187 – volume: 153 start-page: 147 issue: 1 year: 2000 end-page: 153 ident: CR35 article-title: Apolipoprotein E polymorphism and carotid artery intima-media thickness in a random sample of middle-aged men publication-title: Atherosclerosis doi: 10.1016/S0021-9150(00)00383-X – volume: 2022 start-page: 109778 year: 2022 ident: CR42 article-title: Longitudinal association of Apolipoprotein E polymorphism with lipid profile, type 2 diabetes and metabolic syndrome: Results from a 15 year follow-up study publication-title: Diabetes Res. Clin. Pract. doi: 10.1016/j.diabres.2022.109778 – volume: 59 start-page: 25 year: 2020 ident: CR41 article-title: Apolipoprotein E (APOE) genotype-associated disease risks: A phenome-wide, registry-based, case-control study utilising the UK Biobank publication-title: EBioMedicine doi: 10.1016/j.ebiom.2020.102954 – volume: 42 start-page: 475 issue: 2 year: 2013 end-page: 492 ident: CR13 article-title: Apolipoprotein E genotype, cardiovascular biomarkers and risk of stroke: Systematic review and meta-analysis of 14,015 stroke cases and pooled analysis of primary biomarker data from up to 60,883 individuals publication-title: Int. J. Epidemiol. doi: 10.1093/ije/dyt034 – volume: 6 start-page: e005313 issue: 1 year: 2017 ident: CR28 article-title: Carotid intima-media thickness and prediction of cardiovascular disease publication-title: J. Am. Heart Assoc. doi: 10.1161/JAHA.116.005313 – volume: 74 start-page: 1178 issue: 10 year: 2017 end-page: 1189 ident: CR7 article-title: Apolipoprotein E genotype and sex risk factors for Alzheimer disease: A meta-analysis publication-title: JAMA Neurol. doi: 10.1001/jamaneurol.2017.2188 – volume: 62 start-page: 1196 issue: 7 year: 2004 end-page: 1198 ident: CR15 article-title: The impact of APOE on myocardial infarction, stroke, and dementia: The Rotterdam Study publication-title: Neurology doi: 10.1212/01.WNL.0000118302.66674.E1 – volume: 46 start-page: 186 issue: 3 year: 2001 end-page: 194 ident: CR31 article-title: Study of Health In Pomerania (SHIP): A health examination survey in an east German region: Objectives and design publication-title: Soz. Praventivmed. doi: 10.1007/BF01324255 – volume: 36 start-page: 950 issue: 11 year: 2014 end-page: 954 ident: CR12 article-title: APOE ϵ 2 allele is an independent risk factor for vulnerable carotid plaque in ischemic stroke patients publication-title: Neurol. Res. doi: 10.1179/1743132814Y.0000000385 – volume: 120 start-page: 1479 issue: 10 year: 2013 end-page: 1489 ident: CR5 article-title: Meta-analysis of APOE ε2/ε3/ε4 polymorphism and cerebral infarction publication-title: J. Neural Transm. doi: 10.1007/s00702-013-1019-8 – volume: 94 start-page: 739 issue: 7 year: 2016 end-page: 746 ident: CR8 article-title: Apolipoprotein E: From cardiovascular disease to neurodegenerative disorders publication-title: J. Mol. Med. doi: 10.1007/s00109-016-1427-y – volume: 312 start-page: 119 year: 2020 end-page: 120 ident: CR25 article-title: Carotid intima-media thickness should not be referred to as subclinical atherosclerosis: A recommended update to the editorial policy at Atherosclerosis publication-title: Atherosclerosis doi: 10.1016/j.atherosclerosis.2020.09.015 – volume: 31 start-page: 1299 issue: 6 year: 2000 end-page: 1306 ident: CR11 article-title: Age-dependent association of Apolipoprotein E genotypes with stroke subtypes in a Japanese rural population publication-title: Stroke doi: 10.1161/01.STR.31.6.1299 – volume: 11 start-page: 9229 issue: 1 year: 2021 ident: CR4 article-title: Age and sex specific effects of APOE genotypes on ischemic heart disease and its risk factors in the UK Biobank publication-title: Sci. Rep. doi: 10.1038/s41598-021-88256-x – volume: 18 start-page: 118 issue: 3 year: 2002 end-page: 124 ident: CR14 article-title: Association of Apolipoprotein E polymorphism with myocardial infarction in Greek patients with coronary artery disease publication-title: Curr. Med. Res. Opin. doi: 10.1185/030079902125000444 – volume: 39 start-page: 48 issue: 1 year: 2008 end-page: 54 ident: CR22 article-title: Association between Apolipoprotein E genotype and carotid intima-media thickness may suggest a specific effect on large artery atherothrombotic stroke publication-title: Stroke doi: 10.1161/STROKEAHA.107.488866 – volume: 32 start-page: 1947 issue: 9 year: 2001 end-page: 1952 ident: CR21 article-title: Apolipoprotein E and carotid artery atherosclerosis publication-title: Stroke doi: 10.1161/hs0901.095377 – volume: 36 start-page: 2484 issue: 11 year: 2005 end-page: 2486 ident: CR19 article-title: Apolipoprotein E genotype and incident ischemic stroke: The atherosclerosis risk in communities study publication-title: Stroke doi: 10.1161/01.STR.0000185687.28520.3f – volume: 239 start-page: 615 issue: 2 year: 2015 end-page: 621 ident: CR40 article-title: Risk factors for the progression of carotid intima-media thickness over a 16-year follow-up period: The Malmö Diet and Cancer Study publication-title: Atherosclerosis doi: 10.1016/j.atherosclerosis.2015.01.030 – volume: 9 start-page: e104608 issue: 8 year: 2014 ident: CR9 article-title: Meta-analysis of Apolipoprotein E gene polymorphism and susceptibility of myocardial infarction publication-title: PLoS One doi: 10.1371/journal.pone.0104608 – volume: 38 start-page: 2873 issue: 11 year: 2007 end-page: 2880 ident: CR29 article-title: Carotid atherosclerosis is a stronger predictor of myocardial infarction in women than in men publication-title: Stroke doi: 10.1161/STROKEAHA.107.487264 – volume: 31 start-page: 570 issue: 7 year: 2001 end-page: 573 ident: CR17 article-title: Lack of association between Apolipoprotein E genoype and ischaemic stroke in a Scottish population publication-title: Eur. J. Clin. Invest. doi: 10.1046/j.1365-2362.2001.00851.x – volume: 44 start-page: 373 issue: 2 year: 2013 end-page: 379 ident: CR27 article-title: Carotid atherosclerosis and risk of subsequent coronary event in outpatients with atherothrombosis publication-title: Stroke doi: 10.1161/STROKEAHA.112.673129 – volume: 27 start-page: 645 issue: 3 year: 2018 end-page: 652 ident: CR23 article-title: Apolipoprotein E gene polymorphism and subclinical carotid atherosclerosis: The Northern Manhattan study publication-title: J. Stroke Cerebrovasc. Dis. doi: 10.1016/j.jstrokecerebrovasdis.2017.09.053 – volume: 3 start-page: 1224 issue: 6 year: 2005 end-page: 1230 ident: CR34 article-title: Age-adjusted reference limits for carotid intima-media thickness as better indicator of vascular risk: Population-based estimates from the VITA project publication-title: J. Thromb. Haemost. doi: 10.1111/j.1538-7836.2005.01440.x – volume: 15 start-page: 1280 issue: 9 year: 1995 end-page: 1286 ident: CR47 article-title: Apolipoprotein E4 phenotype is not an important risk factor for coronary heart disease or stroke in elderly subjects publication-title: Arterioscler. Thromb. Vasc. Biol. doi: 10.1161/01.ATV.15.9.1280 – volume: 32 start-page: 823 issue: 11 year: 2019 end-page: 838 ident: CR6 article-title: Association between ApoE polymorphism and type 2 diabetes: A meta-analysis of 59 studies publication-title: Biomed. Environ. Sci. – volume: 37 start-page: 1636 issue: 9 year: 2016 end-page: 1642 ident: CR33 article-title: Relationship between APOE genotype and structural MRI measures throughout adulthood in the study of health in Pomerania population-based cohort publication-title: Am. J. Neuroradiol. doi: 10.3174/ajnr.A4805 – volume: 141 start-page: 137 issue: 2 year: 2004 end-page: 147 ident: CR43 article-title: Meta-analysis: Apolipoprotein E genotypes and risk for coronary heart disease publication-title: Ann. Intern. Med. doi: 10.7326/0003-4819-141-2-200407200-00013 – volume: 142 start-page: 621 issue: 7 year: 2020 end-page: 642 ident: CR26 article-title: Carotid intima-media thickness progression as surrogate marker for cardiovascular risk publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.120.046361 – volume: 45 start-page: 1868 issue: 10 year: 2004 end-page: 1875 ident: CR36 article-title: Association of APOE genotype with carotid atherosclerosis in men and women: The Framingham Heart Study publication-title: J. Lipid Res. doi: 10.1194/jlr.M400114-JLR200 – volume: 2016 start-page: 3912175 year: 2016 ident: CR44 article-title: Apolipoprotein E gene variants and risk of coronary heart disease: A meta-analysis publication-title: Biomed. Res. Int. doi: 10.1155/2016/3912175 – volume: 18 start-page: 271 issue: 4 year: 2008 end-page: 277 ident: CR37 article-title: Apolipoprotein E polymorphism is associated with both carotid and coronary atherosclerosis in patients with coronary artery disease publication-title: Nutr. Metab. Cardiovasc. Dis. doi: 10.1016/j.numecd.2007.01.003 – volume: 26 start-page: 2482 issue: 11 year: 2017 end-page: 2493 ident: CR10 article-title: Polymorphisms of MTHFR, eNOS, ACE, AGT, ApoE, PON1, PDE4D, and ischemic stroke: Meta-analysis publication-title: J. Stroke Cerebrovasc. Dis. doi: 10.1016/j.jstrokecerebrovasdis.2017.05.048 – volume: 225 start-page: 486 issue: 2 year: 2012 end-page: 490 ident: CR32 article-title: Psoriasis is associated with increased intima–media thickness—The Study of Health in Pomerania (SHIP) publication-title: Atherosclerosis doi: 10.1016/j.atherosclerosis.2012.09.026 – volume: 13 start-page: 46 year: 2015 end-page: 46 ident: CR38 article-title: Causes of changes in carotid intima-media thickness: A literature review publication-title: Cardiovasc. Ultrasound doi: 10.1186/s12947-015-0041-4 – volume: 27 start-page: 1310 issue: 8 year: 1996 end-page: 1315 ident: CR46 article-title: Apolipoprotein E polymorphism and stroke in a population sample aged 75 years or more publication-title: Stroke doi: 10.1161/01.STR.27.8.1310 – volume: 109 start-page: IV-47 issue: 25_suppl_1 year: 2004 end-page: IV-58 ident: CR2 article-title: Genetic markers publication-title: Circulation doi: 10.1161/01.CIR.0000133440.86427.26 – volume: 40 start-page: 294 issue: 2 year: 2011 end-page: 307 ident: CR30 article-title: Cohort profile: The study of health in pomerania publication-title: Int. J. Epidemiol. doi: 10.1093/ije/dyp394 – volume: 29 start-page: 1882 issue: 9 year: 1998 end-page: 1887 ident: CR48 article-title: The Apolipoprotein E4 allele and outcome in cerebrovascular disease publication-title: Stroke doi: 10.1161/01.STR.29.9.1882 – volume: 166 start-page: 323 issue: 2 year: 2003 end-page: 329 ident: CR16 article-title: A prospective study of the association between APOE genotype and the risk of myocardial infarction among apparently healthy men publication-title: Atherosclerosis doi: 10.1016/S0021-9150(02)00335-0 – volume: 9 start-page: 18011 issue: 1 year: 2019 ident: CR39 article-title: Association between lipid profiles and presence of carotid plaque publication-title: Sci. Rep. doi: 10.1038/s41598-019-54285-w – volume: 9 start-page: 511 issue: 6 year: 2016 end-page: 520 ident: CR20 article-title: Multiethnic exome-wide association study of subclinical atherosclerosis publication-title: Circ. Cardiovasc. Genet. doi: 10.1161/CIRCGENETICS.116.001572 – volume: 45 start-page: 1868 issue: 10 year: 2004 ident: 9129_CR36 publication-title: J. Lipid Res. doi: 10.1194/jlr.M400114-JLR200 – volume: 31 start-page: 1299 issue: 6 year: 2000 ident: 9129_CR11 publication-title: Stroke doi: 10.1161/01.STR.31.6.1299 – volume: 62 start-page: 1196 issue: 7 year: 2004 ident: 9129_CR15 publication-title: Neurology doi: 10.1212/01.WNL.0000118302.66674.E1 – volume: 120 start-page: 1479 issue: 10 year: 2013 ident: 9129_CR5 publication-title: J. Neural Transm. doi: 10.1007/s00702-013-1019-8 – volume: 9 start-page: e104608 issue: 8 year: 2014 ident: 9129_CR9 publication-title: PLoS One doi: 10.1371/journal.pone.0104608 – volume: 27 start-page: 1310 issue: 8 year: 1996 ident: 9129_CR46 publication-title: Stroke doi: 10.1161/01.STR.27.8.1310 – volume: 36 start-page: 950 issue: 11 year: 2014 ident: 9129_CR12 publication-title: Neurol. Res. doi: 10.1179/1743132814Y.0000000385 – volume: 32 start-page: 1947 issue: 9 year: 2001 ident: 9129_CR21 publication-title: Stroke doi: 10.1161/hs0901.095377 – volume: 31 start-page: 570 issue: 7 year: 2001 ident: 9129_CR17 publication-title: Eur. J. Clin. Invest. doi: 10.1046/j.1365-2362.2001.00851.x – volume: 3 start-page: 1224 issue: 6 year: 2005 ident: 9129_CR34 publication-title: J. Thromb. Haemost. doi: 10.1111/j.1538-7836.2005.01440.x – volume: 38 start-page: 2873 issue: 11 year: 2007 ident: 9129_CR29 publication-title: Stroke doi: 10.1161/STROKEAHA.107.487264 – volume: 9 start-page: 18011 issue: 1 year: 2019 ident: 9129_CR39 publication-title: Sci. Rep. doi: 10.1038/s41598-019-54285-w – volume: 13 start-page: 46 year: 2015 ident: 9129_CR38 publication-title: Cardiovasc. Ultrasound doi: 10.1186/s12947-015-0041-4 – volume: 239 start-page: 615 issue: 2 year: 2015 ident: 9129_CR40 publication-title: Atherosclerosis doi: 10.1016/j.atherosclerosis.2015.01.030 – volume: 15 start-page: 1280 issue: 9 year: 1995 ident: 9129_CR47 publication-title: Arterioscler. Thromb. Vasc. Biol. doi: 10.1161/01.ATV.15.9.1280 – volume: 44 start-page: 373 issue: 2 year: 2013 ident: 9129_CR27 publication-title: Stroke doi: 10.1161/STROKEAHA.112.673129 – volume: 2016 start-page: 3912175 year: 2016 ident: 9129_CR44 publication-title: Biomed. Res. Int. doi: 10.1155/2016/3912175 – volume: 94 start-page: 739 issue: 7 year: 2016 ident: 9129_CR8 publication-title: J. Mol. Med. doi: 10.1007/s00109-016-1427-y – volume: 27 start-page: 645 issue: 3 year: 2018 ident: 9129_CR23 publication-title: J. Stroke Cerebrovasc. Dis. doi: 10.1016/j.jstrokecerebrovasdis.2017.09.053 – volume: 153 start-page: 147 issue: 1 year: 2000 ident: 9129_CR35 publication-title: Atherosclerosis doi: 10.1016/S0021-9150(00)00383-X – volume: 39 start-page: 48 issue: 1 year: 2008 ident: 9129_CR22 publication-title: Stroke doi: 10.1161/STROKEAHA.107.488866 – volume: 37 start-page: 1636 issue: 9 year: 2016 ident: 9129_CR33 publication-title: Am. J. Neuroradiol. doi: 10.3174/ajnr.A4805 – volume: 74 start-page: 1178 issue: 10 year: 2017 ident: 9129_CR7 publication-title: JAMA Neurol. doi: 10.1001/jamaneurol.2017.2188 – volume: 11 start-page: 9229 issue: 1 year: 2021 ident: 9129_CR4 publication-title: Sci. Rep. doi: 10.1038/s41598-021-88256-x – volume: 225 start-page: 486 issue: 2 year: 2012 ident: 9129_CR32 publication-title: Atherosclerosis doi: 10.1016/j.atherosclerosis.2012.09.026 – volume: 166 start-page: 323 issue: 2 year: 2003 ident: 9129_CR16 publication-title: Atherosclerosis doi: 10.1016/S0021-9150(02)00335-0 – volume: 312 start-page: 119 year: 2020 ident: 9129_CR25 publication-title: Atherosclerosis doi: 10.1016/j.atherosclerosis.2020.09.015 – volume: 2022 start-page: 109778 year: 2022 ident: 9129_CR42 publication-title: Diabetes Res. Clin. Pract. doi: 10.1016/j.diabres.2022.109778 – volume: 141 start-page: 137 issue: 2 year: 2004 ident: 9129_CR43 publication-title: Ann. Intern. Med. doi: 10.7326/0003-4819-141-2-200407200-00013 – volume: 29 start-page: 1882 issue: 9 year: 1998 ident: 9129_CR48 publication-title: Stroke doi: 10.1161/01.STR.29.9.1882 – volume: 142 start-page: 621 issue: 7 year: 2020 ident: 9129_CR26 publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.120.046361 – volume: 109 start-page: IV-47 issue: 25_suppl_1 year: 2004 ident: 9129_CR2 publication-title: Circulation doi: 10.1161/01.CIR.0000133440.86427.26 – volume: 6 start-page: e005313 issue: 1 year: 2017 ident: 9129_CR28 publication-title: J. Am. Heart Assoc. doi: 10.1161/JAHA.116.005313 – volume: 59 start-page: 25 year: 2020 ident: 9129_CR41 publication-title: EBioMedicine doi: 10.1016/j.ebiom.2020.102954 – volume: 42 start-page: 475 issue: 2 year: 2013 ident: 9129_CR13 publication-title: Int. J. Epidemiol. doi: 10.1093/ije/dyt034 – volume: 34 start-page: 869 issue: 4 year: 2003 ident: 9129_CR24 publication-title: Stroke doi: 10.1161/01.STR.0000062901.54157.12 – volume: 18 start-page: 271 issue: 4 year: 2008 ident: 9129_CR37 publication-title: Nutr. Metab. Cardiovasc. Dis. doi: 10.1016/j.numecd.2007.01.003 – volume: 26 start-page: 2482 issue: 11 year: 2017 ident: 9129_CR10 publication-title: J. Stroke Cerebrovasc. Dis. doi: 10.1016/j.jstrokecerebrovasdis.2017.05.048 – volume: 36 start-page: 2484 issue: 11 year: 2005 ident: 9129_CR19 publication-title: Stroke doi: 10.1161/01.STR.0000185687.28520.3f – volume: 9 start-page: 511 issue: 6 year: 2016 ident: 9129_CR20 publication-title: Circ. Cardiovasc. Genet. doi: 10.1161/CIRCGENETICS.116.001572 – volume: 46 start-page: 186 issue: 3 year: 2001 ident: 9129_CR31 publication-title: Soz. Praventivmed. doi: 10.1007/BF01324255 – volume: 18 start-page: 118 issue: 3 year: 2002 ident: 9129_CR14 publication-title: Curr. Med. Res. Opin. doi: 10.1185/030079902125000444 – ident: 9129_CR45 doi: 10.1016/j.atherosclerosis.2016.01.009 – volume: 32 start-page: 823 issue: 11 year: 2019 ident: 9129_CR6 publication-title: Biomed. Environ. Sci. – volume: 40 start-page: 294 issue: 2 year: 2011 ident: 9129_CR30 publication-title: Int. J. Epidemiol. doi: 10.1093/ije/dyp394 – volume: 28 start-page: 2410 issue: 12 year: 1997 ident: 9129_CR18 publication-title: Stroke doi: 10.1161/01.STR.28.12.2410 – volume: 22 start-page: 365 issue: 4 year: 2017 ident: 9129_CR1 publication-title: J. Cardiovasc. Pharmacol. Ther. doi: 10.1177/1074248416686187 – volume: 5 start-page: 852 year: 2015 ident: 9129_CR3 publication-title: FEBS Open Bio doi: 10.1016/j.fob.2015.10.006 |
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| Snippet | The Apolipoprotein E (APOE) gene polymorphism (rs429358 and rs7412) shows a well-established association with lipid profiles, but its effect on cardiovascular... Abstract The Apolipoprotein E (APOE) gene polymorphism (rs429358 and rs7412) shows a well-established association with lipid profiles, but its effect on... |
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| SubjectTerms | 692/4019 692/499 Alleles Apolipoprotein E4 Apolipoproteins Apolipoproteins E - genetics Cardiovascular diseases Carotid artery Carotid Intima-Media Thickness Cerebral infarction Gene polymorphism Heart attacks Homozygotes Humanities and Social Sciences Humans multidisciplinary Myocardial infarction Myocardial Infarction - epidemiology Myocardial Infarction - genetics Plaque, Atherosclerotic Plaques Polymorphism Polymorphism, Genetic Population studies Regression analysis Risk Factors Science Science (multidisciplinary) Stroke Stroke - epidemiology Stroke - genetics |
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| Title | Effects of Apolipoprotein E polymorphism on carotid intima-media thickness, incident myocardial infarction and incident stroke |
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