Atlas of plasma NMR biomarkers for health and disease in 118,461 individuals from the UK Biobank

Blood lipids and metabolites are markers of current health and future disease risk. Here, we describe plasma nuclear magnetic resonance (NMR) biomarker data for 118,461 participants in the UK Biobank. The biomarkers cover 249 measures of lipoprotein lipids, fatty acids, and small molecules such as a...

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Vydáno v:Nature communications Ročník 14; číslo 1; s. 604 - 15
Hlavní autoři: Julkunen, Heli, Cichońska, Anna, Tiainen, Mika, Koskela, Harri, Nybo, Kristian, Mäkelä, Valtteri, Nokso-Koivisto, Jussi, Kristiansson, Kati, Perola, Markus, Salomaa, Veikko, Jousilahti, Pekka, Lundqvist, Annamari, Kangas, Antti J., Soininen, Pasi, Barrett, Jeffrey C., Würtz, Peter
Médium: Journal Article
Jazyk:angličtina
Vydáno: London Nature Publishing Group UK 03.02.2023
Nature Publishing Group
Nature Portfolio
Témata:
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631/45/535/878/1263
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Amino acids
Biobanks
Biological Specimen Banks
Biomarkers
Blood
Cardiovascular diseases
Clustering
Diabetes mellitus
Disease
Fatty acids
Glycolysis
Health risks
Heart diseases
Humanities and Social Sciences
Humans
Infectious diseases
Ketones
Lipid metabolism
Lipids
Magnetic Resonance Spectroscopy - methods
Mental health
Metabolism
Metabolites
multidisciplinary
NMR
Nuclear magnetic resonance
Public health
Risk
Science
Science (multidisciplinary)
United Kingdom - epidemiology
United Kingdom
United Kingdom > UK
ISSN:2041-1723, 2041-1723
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Shrnutí:Blood lipids and metabolites are markers of current health and future disease risk. Here, we describe plasma nuclear magnetic resonance (NMR) biomarker data for 118,461 participants in the UK Biobank. The biomarkers cover 249 measures of lipoprotein lipids, fatty acids, and small molecules such as amino acids, ketones, and glycolysis metabolites. We provide an atlas of associations of these biomarkers to prevalence, incidence, and mortality of over 700 common diseases ( nightingalehealth.com/atlas ). The results reveal a plethora of biomarker associations, including susceptibility to infectious diseases and risk of various cancers, joint disorders, and mental health outcomes, indicating that abundant circulating lipids and metabolites are risk markers beyond cardiometabolic diseases. Clustering analyses indicate similar biomarker association patterns across different disease types, suggesting latent systemic connectivity in the susceptibility to a diverse set of diseases. This work highlights the value of NMR based metabolic biomarker profiling in large biobanks for public health research and translation. The authors report a systematic analyses of blood biomarkers for metabolism against the whole spectrum of diseases in 100,000 individuals and reveals a prominent role of numerous metabolic biomarkers as risk markers beyond heart disease and diabetes.
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ISSN:2041-1723
2041-1723
DOI:10.1038/s41467-023-36231-7