Methylation and expression of glucocorticoid receptor exon-1 variants and FKBP5 in teenage suicide-completers

A dysregulated hypothalamic-pituitary-adrenal (HPA) axis has repeatedly been demonstrated to play a fundamental role in psychiatric disorders and suicide, yet the mechanisms underlying this dysregulation are not clear. Decreased expression of the glucocorticoid receptor (GR) gene, which is also susc...

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Bibliographic Details
Published in:	Translational psychiatry Vol. 13; no. 1; pp. 53 - 9
Main Authors:	Rizavi, Hooriyah S., Khan, Omar S., Zhang, Hui, Bhaumik, Runa, Grayson, Dennis R., Pandey, Ghanshyam N.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 13.02.2023 Nature Publishing Group
Subjects:	38/22 38/39 38/77 631/378/2584/2585 692/53 Adolescent Behavioral Sciences Biological Psychology DNA Methylation Enzymes Epigenetics Exons Gene expression Glucocorticoids - metabolism Humans Hypothalamo-Hypophyseal System - metabolism Medicine Medicine & Public Health Neurosciences Pharmacotherapy Pituitary-Adrenal System - metabolism Psychiatry Receptors, Glucocorticoid - genetics Receptors, Glucocorticoid - metabolism Suicide, Completed Suicides & suicide attempts Tacrolimus Binding Proteins - genetics Tacrolimus Binding Proteins - metabolism
ISSN:	2158-3188, 2158-3188
Online Access:	Get full text
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