Methylation and expression of glucocorticoid receptor exon-1 variants and FKBP5 in teenage suicide-completers

A dysregulated hypothalamic-pituitary-adrenal (HPA) axis has repeatedly been demonstrated to play a fundamental role in psychiatric disorders and suicide, yet the mechanisms underlying this dysregulation are not clear. Decreased expression of the glucocorticoid receptor (GR) gene, which is also susc...

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Vydané v:	Translational psychiatry Ročník 13; číslo 1; s. 53 - 9
Hlavní autori:	Rizavi, Hooriyah S., Khan, Omar S., Zhang, Hui, Bhaumik, Runa, Grayson, Dennis R., Pandey, Ghanshyam N.
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	London Nature Publishing Group UK 13.02.2023 Nature Publishing Group
Predmet:	38/22 38/39 38/77 631/378/2584/2585 692/53 Adolescent Behavioral Sciences Biological Psychology DNA Methylation Enzymes Epigenetics Exons Gene expression Glucocorticoids - metabolism Humans Hypothalamo-Hypophyseal System - metabolism Medicine Medicine & Public Health Neurosciences Pharmacotherapy Pituitary-Adrenal System - metabolism Psychiatry Receptors, Glucocorticoid - genetics Receptors, Glucocorticoid - metabolism Suicide, Completed Suicides & suicide attempts Tacrolimus Binding Proteins - genetics Tacrolimus Binding Proteins - metabolism
ISSN:	2158-3188, 2158-3188
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