Hydrogels with intrinsic antibacterial activity prepared from naphthyl anthranilamide (NaA) capped peptide mimics

In this study, we prepared antibacterial hydrogels through the self-assembly of naphthyl anthranilamide (NaA) capped amino acid based cationic peptide mimics. These ultra-short cationic peptide mimics were rationally designed with NaA as a capping group, l -phenylalanine, a short aliphatic linker, a...

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Vydáno v:Scientific reports Ročník 12; číslo 1; s. 22259 - 12
Hlavní autoři: Aldilla, Vina R., Chen, Renxun, Kuppusamy, Rajesh, Chakraborty, Sudip, Willcox, Mark D. P., Black, David StC, Thordarson, Pall, Martin, Adam D., Kumar, Naresh
Médium: Journal Article
Jazyk:angličtina
Vydáno: London Nature Publishing Group UK 23.12.2022
Nature Publishing Group
Nature Portfolio
Témata:
631/326/22
639/638/298/923/1027
639/638/298/923/966
Amino acids
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - pharmacology
Antibacterial activity
Antimicrobial agents
Bacteria
Biocompatibility
Cations
Contamination
Cytotoxicity
Design
E coli
Gram-Negative Bacteria
Gram-Positive Bacteria
Humanities and Social Sciences
Hydrogels
Hydrogels - chemistry
Mechanical properties
Microbial Sensitivity Tests
Morphology
multidisciplinary
Peptides
Peptides - chemistry
Phenylalanine
Science
Science (multidisciplinary)
Self-assembly
Viscoelasticity
ISSN:2045-2322, 2045-2322
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Shrnutí:In this study, we prepared antibacterial hydrogels through the self-assembly of naphthyl anthranilamide (NaA) capped amino acid based cationic peptide mimics. These ultra-short cationic peptide mimics were rationally designed with NaA as a capping group, l -phenylalanine, a short aliphatic linker, and a cationic group. The synthesized peptide mimics efficiently formed hydrogels with minimum gel concentrations between 0.1 and 0.3%w/v. The resulting hydrogels exhibited desirable viscoelastic properties which can be tuned by varying the cationic group, electronegative substituent, or counter anion. Importantly, nanofibers from the NaA-capped cationic hydrogels were found to be the source of hydrogels’ potent bacteriacidal actvity against both Gram-positive and Gram-negative bacteria while remaining non-cytotoxic. These intrinsically antibacterial hydrogels are ideal candidates for further development in applications where bacterial contamination is problematic.
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ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-022-26426-1