A single-cell atlas of human and mouse white adipose tissue

White adipose tissue, once regarded as morphologically and functionally bland, is now recognized to be dynamic, plastic and heterogenous, and is involved in a wide array of biological processes including energy homeostasis, glucose and lipid handling, blood pressure control and host defence 1 . High...

Celý popis

Uloženo v:

Podrobná bibliografie
Vydáno v:	Nature (London) Ročník 603; číslo 7903; s. 926 - 933
Hlavní autoři:	Emont, Margo P., Jacobs, Christopher, Essene, Adam L., Pant, Deepti, Tenen, Danielle, Colleluori, Georgia, Di Vincenzo, Angelica, Jørgensen, Anja M., Dashti, Hesam, Stefek, Adam, McGonagle, Elizabeth, Strobel, Sophie, Laber, Samantha, Agrawal, Saaket, Westcott, Gregory P., Kar, Amrita, Veregge, Molly L., Gulko, Anton, Srinivasan, Harini, Kramer, Zachary, De Filippis, Eleanna, Merkel, Erin, Ducie, Jennifer, Boyd, Christopher G., Gourash, William, Courcoulas, Anita, Lin, Samuel J., Lee, Bernard T., Morris, Donald, Tobias, Adam, Khera, Amit V., Claussnitzer, Melina, Pers, Tune H., Giordano, Antonio, Ashenberg, Orr, Regev, Aviv, Tsai, Linus T., Rosen, Evan D.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	London Nature Publishing Group UK 31.03.2022 Nature Publishing Group
Témata:	14/1 38/43 38/91 631/443/319/1642/393 631/443/319/2723 64/60 96/106 Adipocytes Adipose tissue Adipose Tissue - metabolism Adipose Tissue, White - metabolism Adiposity Animals Atlases as Topic Biological activity Blood pressure Body fat Body mass index Body weight Cells (biology) Datasets Dendritic cells Diabetes Mellitus, Type 2 - metabolism Dyslipidemia Energy balance Females Homeostasis Humanities and Social Sciences Humans Immune system Insulin Insulin Resistance Lipids Lymphocytes Males Metabolic Diseases Metabolic disorders Metabolism Mice Morphology multidisciplinary Neutrophils Obesity Obesity - metabolism Progenitor cells Science Science (multidisciplinary) Stem cells Subpopulations
ISSN:	0028-0836, 1476-4687, 1476-4687
On-line přístup:	Získat plný text
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!

Popis
Shrnutí:	White adipose tissue, once regarded as morphologically and functionally bland, is now recognized to be dynamic, plastic and heterogenous, and is involved in a wide array of biological processes including energy homeostasis, glucose and lipid handling, blood pressure control and host defence 1 . High-fat feeding and other metabolic stressors cause marked changes in adipose morphology, physiology and cellular composition 1 , and alterations in adiposity are associated with insulin resistance, dyslipidemia and type 2 diabetes 2 . Here we provide detailed cellular atlases of human and mouse subcutaneous and visceral white fat at single-cell resolution across a range of body weight. We identify subpopulations of adipocytes, adipose stem and progenitor cells, vascular and immune cells and demonstrate commonalities and differences across species and dietary conditions. We link specific cell types to increased risk of metabolic disease and provide an initial blueprint for a comprehensive set of interactions between individual cell types in the adipose niche in leanness and obesity. These data comprise an extensive resource for the exploration of genes, traits and cell types in the function of white adipose tissue across species, depots and nutritional conditions. A single-cell atlas of white adipose tissue from mouse and human reveals diverse cell types and similarities and differences across species and dietary conditions.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 AUTHOR CONTRIBUTIONS MPE, LTT, and EDR conceived of the project. MPE and EDR wrote the manuscript with assistance from LTT, CJ, OA, and AR. MPE, ALE, DP, DT, GC, ADV, AS, EM, SS, SL, GPW, MLV, and AGu performed experiments. GPW, AGu, ZK, JD, CGB, WG, AC, SJL, BTL, DM, and AT collected samples. MPE, CJ, AMJ, HD, SA, AK, and HS performed computational analysis. AVK, MC, THP, AGi, OA, and AR provided additional intellectual input.
ISSN:	0028-0836 1476-4687 1476-4687
DOI:	10.1038/s41586-022-04518-2