Parent-of-Origin inference for biobanks

Identical genetic variations can have different phenotypic effects depending on their parent of origin. Yet, studies focusing on parent-of-origin effects have been limited in terms of sample size due to the lack of parental genomes or known genealogies. We propose a probabilistic approach to infer t...

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Bibliographic Details
Published in:	Nature communications Vol. 13; no. 1; pp. 6668 - 15
Main Authors:	Hofmeister, Robin J., Rubinacci, Simone, Ribeiro, Diogo M., Buil, Alfonso, Kutalik, Zoltán, Delaneau, Olivier
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 05.11.2022 Nature Publishing Group Nature Portfolio
Subjects:	45 45/43 631/114/2397 631/208/176/1968 631/208/205/2138 Alleles Biobanks Biological Specimen Banks Biomarkers Body mass index Body size Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 Female Genealogy Genetic diversity Genome-Wide Association Study Genomes Haplotypes Heritability Humanities and Social Sciences Humans Inference Male Molecular modelling multidisciplinary Phenotype Phenotypes Phenotypic variations Preadipocyte factor 1 Science Science (multidisciplinary) Telomeres
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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