Mitochondrial autophagy: molecular mechanisms and implications for cardiovascular disease

Mitochondria are highly dynamic organelles that participate in ATP generation and involve calcium homeostasis, oxidative stress response, and apoptosis. Dysfunctional or damaged mitochondria could cause serious consequences even lead to cell death. Therefore, maintaining the homeostasis of mitochond...

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Vydáno v:Cell death & disease Ročník 13; číslo 5; s. 444 - 15
Hlavní autoři: Li, Anqi, Gao, Meng, Liu, Bilin, Qin, Yuan, chen, Lei, Liu, Hanyu, Wu, Huayan, Gong, Guohua
Médium: Journal Article
Jazyk:angličtina
Vydáno: London Nature Publishing Group UK 09.05.2022
Springer Nature B.V
Nature Publishing Group
Témata:
14/34
14/63
631/80/642/333
692/699/75
Antibodies
Apoptosis
Autophagy
Biochemistry
Biomedical and Life Sciences
Calcium homeostasis
Cardiomyopathy
Cardiovascular disease
Cardiovascular diseases
Cardiovascular Diseases - pathology
Cell Biology
Cell Culture
Cell death
Cellular stress response
Congestive heart failure
Heart diseases
Homeostasis
Humans
Immunology
Life Sciences
Mitochondria
Mitochondria - metabolism
Mitophagy - physiology
Molecular modelling
Myocardial infarction
Myocardium
Organelles
Oxidative stress
Quality control
Review
Review Article
Toxicity
ISSN:2041-4889, 2041-4889
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Shrnutí:Mitochondria are highly dynamic organelles that participate in ATP generation and involve calcium homeostasis, oxidative stress response, and apoptosis. Dysfunctional or damaged mitochondria could cause serious consequences even lead to cell death. Therefore, maintaining the homeostasis of mitochondria is critical for cellular functions. Mitophagy is a process of selectively degrading damaged mitochondria under mitochondrial toxicity conditions, which plays an essential role in mitochondrial quality control. The abnormal mitophagy that aggravates mitochondrial dysfunction is closely related to the pathogenesis of many diseases. As the myocardium is a highly oxidative metabolic tissue, mitochondria play a central role in maintaining optimal performance of the heart. Dysfunctional mitochondria accumulation is involved in the pathophysiology of cardiovascular diseases, such as myocardial infarction, cardiomyopathy and heart failure. This review discusses the most recent progress on mitophagy and its role in cardiovascular disease.
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ISSN:2041-4889
2041-4889
DOI:10.1038/s41419-022-04906-6