Temporal profiling of the breast tumour microenvironment reveals collagen XII as a driver of metastasis

The tumour stroma, and in particular the extracellular matrix (ECM), is a salient feature of solid tumours that plays a crucial role in shaping their progression. Many desmoplastic tumours including breast cancer involve the significant accumulation of type I collagen. However, recently it has becom...

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Bibliographic Details
Published in:	Nature communications Vol. 13; no. 1; pp. 4587 - 21
Main Authors:	Papanicolaou, Michael, Parker, Amelia L., Yam, Michelle, Filipe, Elysse C., Wu, Sunny Z., Chitty, Jessica L., Wyllie, Kaitlin, Tran, Emmi, Mok, Ellie, Nadalini, Audrey, Skhinas, Joanna N., Lucas, Morghan C., Herrmann, David, Nobis, Max, Pereira, Brooke A., Law, Andrew M. K., Castillo, Lesley, Murphy, Kendelle J., Zaratzian, Anaiis, Hastings, Jordan F., Croucher, David R., Lim, Elgene, Oliver, Brian G., Mora, Fatima Valdes, Parker, Benjamin L., Gallego-Ortega, David, Swarbrick, Alexander, O’Toole, Sandra, Timpson, Paul, Cox, Thomas R.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 06.08.2022 Nature Publishing Group Nature Portfolio
Subjects:	631/67/1347 631/67/327 64/60 82/58 Breast cancer Breast Neoplasms - pathology Collagen Collagen Type I Collagen Type XII - metabolism Critical components Extracellular matrix Extracellular Matrix - pathology Female Fibroblasts Humanities and Social Sciences Humans Invasiveness Metastases Metastasis Microenvironments multidisciplinary Neoplasm Metastasis - pathology Neoplasm Recurrence, Local - pathology Proteomics Science Science (multidisciplinary) Solid tumors Stroma Transcriptomics Tumor Microenvironment Tumors
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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