Long noncoding RNA LINC00239 inhibits ferroptosis in colorectal cancer by binding to Keap1 to stabilize Nrf2

Ferroptosis, a novel regulated cell death induced by iron-dependent lipid peroxidation, plays an important role in tumor development and drug resistance. Long noncoding RNAs (lncRNAs) are associated with various types of cancer. However, the precise roles of many lncRNAs in tumorigenesis remain elus...

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Veröffentlicht in:	Cell death & disease Jg. 13; H. 8; S. 742 - 13
Hauptverfasser:	Han, Yuying, Gao, Xiaoliang, Wu, Nan, Jin, Yirong, Zhou, He, Wang, Weijie, Liu, Hao, Chu, Yi, Cao, Jiayi, Jiang, Mingzuo, Yang, Suzhen, Shi, Yanting, Xie, Xin, Chen, Fulin, Han, Ying, Qin, Wen, Xu, Bing, Liang, Jie
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 29.08.2022 Springer Nature B.V Nature Publishing Group
Schlagworte:	101/58 13/109 13/51 14/19 38 38/1 45/15 45/91 631/67/1504/1885 631/80/82 96/95 Antibodies Antitumor agents Binding sites Biochemistry Biomedical and Life Sciences Cancer Cell Biology Cell Culture Cell death Chemoresistance Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - pathology Drug resistance Ferroptosis Ferroptosis - genetics Humans Immunology Kelch-Like ECH-Associated Protein 1 - genetics Kelch-Like ECH-Associated Protein 1 - metabolism Life Sciences Lipid peroxidation Medical prognosis NF-E2-Related Factor 2 - metabolism Non-coding RNA NRF2 protein Nucleotides RNA, Long Noncoding - genetics RNA, Long Noncoding - metabolism Transcriptomics Tumorigenesis Ubiquitination Xenografts
ISSN:	2041-4889, 2041-4889
Online-Zugang:	Volltext
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