Quantitative perfusion imaging of neoplastic liver lesions: A multi-institution study

We describe multi-institutional experience using free-breathing, 3D Spiral GRAPPA-based quantitative perfusion MRI in characterizing neoplastic liver masses. 45 patients (age: 48–72 years) were prospectively recruited at University Hospitals, Cleveland, USA on a 3 Tesla (T) MRI, and at Zhongshan Hos...

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Vydáno v:Scientific reports Ročník 8; číslo 1; s. 4990 - 8
Hlavní autoři: Pahwa, Shivani, Liu, Hao, Chen, Yong, Dastmalchian, Sara, O’Connor, Gregory, Lu, Ziang, Badve, Chaitra, Yu, Alice, Wright, Katherine, Chalian, Hamid, Rao, Shengxiang, Fu, Caixia, Vallines, Ignacio, Griswold, Mark, Seiberlich, Nicole, Zeng, Mengsu, Gulani, Vikas
Médium: Journal Article
Jazyk:angličtina
Vydáno: London Nature Publishing Group UK 21.03.2018
Nature Publishing Group
Nature Portfolio
Témata:
59/57
692/308/575
692/700/1421/1628
Hepatocellular carcinoma
Humanities and Social Sciences
Lesions
Liver
Liver cancer
Magnetic resonance imaging
Metastases
Metastasis
multidisciplinary
Parenchyma
Perfusion
Respiration
Science
Science (multidisciplinary)
Statistical analysis
ISSN:2045-2322, 2045-2322
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Abstract We describe multi-institutional experience using free-breathing, 3D Spiral GRAPPA-based quantitative perfusion MRI in characterizing neoplastic liver masses. 45 patients (age: 48–72 years) were prospectively recruited at University Hospitals, Cleveland, USA on a 3 Tesla (T) MRI, and at Zhongshan Hospital, Shanghai, China on a 1.5 T MRI. Contrast-enhanced volumetric T1-weighted images were acquired and a dual-input single-compartment model used to derive arterial fraction (AF), distribution volume (DV) and mean transit time (MTT) for the lesions and normal parenchyma. The measurements were compared using two-tailed Student’s t-test, with Bonferroni correction applied for multiple-comparison testing. 28 hepatocellular carcinoma (HCC) and 17 metastatic lesions were evaluated. No significant difference was noted in perfusion parameters of normal liver parenchyma and neoplastic masses at two centers (p = 0.62 for AF, 0.015 for DV, 0.42 for MTT for HCC, p = 0.13 for AF, 0.97 for DV, 0.78 for MTT for metastases). There was statistically significant difference in AF, DV, and MTT of metastases and AF and DV of HCC compared to normal liver parenchyma (p < 0.5/9 = 0.0055). A statistically significant difference was noted in the MTT of metastases compared to hepatocellular carcinoma (p < 0.001*10-5). In conclusion, 3D Spiral-GRAPPA enabled quantitative free-breathing perfusion MRI exam provides robust perfusion parameters.
AbstractList Abstract We describe multi-institutional experience using free-breathing, 3D Spiral GRAPPA-based quantitative perfusion MRI in characterizing neoplastic liver masses. 45 patients (age: 48–72 years) were prospectively recruited at University Hospitals, Cleveland, USA on a 3 Tesla (T) MRI, and at Zhongshan Hospital, Shanghai, China on a 1.5 T MRI. Contrast-enhanced volumetric T1-weighted images were acquired and a dual-input single-compartment model used to derive arterial fraction (AF), distribution volume (DV) and mean transit time (MTT) for the lesions and normal parenchyma. The measurements were compared using two-tailed Student’s t-test, with Bonferroni correction applied for multiple-comparison testing. 28 hepatocellular carcinoma (HCC) and 17 metastatic lesions were evaluated. No significant difference was noted in perfusion parameters of normal liver parenchyma and neoplastic masses at two centers (p = 0.62 for AF, 0.015 for DV, 0.42 for MTT for HCC, p = 0.13 for AF, 0.97 for DV, 0.78 for MTT for metastases). There was statistically significant difference in AF, DV, and MTT of metastases and AF and DV of HCC compared to normal liver parenchyma (p < 0.5/9 = 0.0055). A statistically significant difference was noted in the MTT of metastases compared to hepatocellular carcinoma (p < 0.001*10-5). In conclusion, 3D Spiral-GRAPPA enabled quantitative free-breathing perfusion MRI exam provides robust perfusion parameters.
We describe multi-institutional experience using free-breathing, 3D Spiral GRAPPA-based quantitative perfusion MRI in characterizing neoplastic liver masses. 45 patients (age: 48–72 years) were prospectively recruited at University Hospitals, Cleveland, USA on a 3 Tesla (T) MRI, and at Zhongshan Hospital, Shanghai, China on a 1.5 T MRI. Contrast-enhanced volumetric T1-weighted images were acquired and a dual-input single-compartment model used to derive arterial fraction (AF), distribution volume (DV) and mean transit time (MTT) for the lesions and normal parenchyma. The measurements were compared using two-tailed Student’s t-test, with Bonferroni correction applied for multiple-comparison testing. 28 hepatocellular carcinoma (HCC) and 17 metastatic lesions were evaluated. No significant difference was noted in perfusion parameters of normal liver parenchyma and neoplastic masses at two centers (p = 0.62 for AF, 0.015 for DV, 0.42 for MTT for HCC, p = 0.13 for AF, 0.97 for DV, 0.78 for MTT for metastases). There was statistically significant difference in AF, DV, and MTT of metastases and AF and DV of HCC compared to normal liver parenchyma (p < 0.5/9 = 0.0055). A statistically significant difference was noted in the MTT of metastases compared to hepatocellular carcinoma (p < 0.001*10-5). In conclusion, 3D Spiral-GRAPPA enabled quantitative free-breathing perfusion MRI exam provides robust perfusion parameters.
We describe multi-institutional experience using free-breathing, 3D Spiral GRAPPA-based quantitative perfusion MRI in characterizing neoplastic liver masses. 45 patients (age: 48-72 years) were prospectively recruited at University Hospitals, Cleveland, USA on a 3 Tesla (T) MRI, and at Zhongshan Hospital, Shanghai, China on a 1.5 T MRI. Contrast-enhanced volumetric T1-weighted images were acquired and a dual-input single-compartment model used to derive arterial fraction (AF), distribution volume (DV) and mean transit time (MTT) for the lesions and normal parenchyma. The measurements were compared using two-tailed Student's t-test, with Bonferroni correction applied for multiple-comparison testing. 28 hepatocellular carcinoma (HCC) and 17 metastatic lesions were evaluated. No significant difference was noted in perfusion parameters of normal liver parenchyma and neoplastic masses at two centers (p = 0.62 for AF, 0.015 for DV, 0.42 for MTT for HCC, p = 0.13 for AF, 0.97 for DV, 0.78 for MTT for metastases). There was statistically significant difference in AF, DV, and MTT of metastases and AF and DV of HCC compared to normal liver parenchyma (p < 0.5/9 = 0.0055). A statistically significant difference was noted in the MTT of metastases compared to hepatocellular carcinoma (p < 0.001*10-5). In conclusion, 3D Spiral-GRAPPA enabled quantitative free-breathing perfusion MRI exam provides robust perfusion parameters.We describe multi-institutional experience using free-breathing, 3D Spiral GRAPPA-based quantitative perfusion MRI in characterizing neoplastic liver masses. 45 patients (age: 48-72 years) were prospectively recruited at University Hospitals, Cleveland, USA on a 3 Tesla (T) MRI, and at Zhongshan Hospital, Shanghai, China on a 1.5 T MRI. Contrast-enhanced volumetric T1-weighted images were acquired and a dual-input single-compartment model used to derive arterial fraction (AF), distribution volume (DV) and mean transit time (MTT) for the lesions and normal parenchyma. The measurements were compared using two-tailed Student's t-test, with Bonferroni correction applied for multiple-comparison testing. 28 hepatocellular carcinoma (HCC) and 17 metastatic lesions were evaluated. No significant difference was noted in perfusion parameters of normal liver parenchyma and neoplastic masses at two centers (p = 0.62 for AF, 0.015 for DV, 0.42 for MTT for HCC, p = 0.13 for AF, 0.97 for DV, 0.78 for MTT for metastases). There was statistically significant difference in AF, DV, and MTT of metastases and AF and DV of HCC compared to normal liver parenchyma (p < 0.5/9 = 0.0055). A statistically significant difference was noted in the MTT of metastases compared to hepatocellular carcinoma (p < 0.001*10-5). In conclusion, 3D Spiral-GRAPPA enabled quantitative free-breathing perfusion MRI exam provides robust perfusion parameters.
ArticleNumber 4990
Author Liu, Hao
Pahwa, Shivani
Zeng, Mengsu
Lu, Ziang
Chalian, Hamid
Rao, Shengxiang
Dastmalchian, Sara
Badve, Chaitra
Griswold, Mark
Gulani, Vikas
O’Connor, Gregory
Seiberlich, Nicole
Vallines, Ignacio
Yu, Alice
Fu, Caixia
Chen, Yong
Wright, Katherine
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  organization: Radiology, Zhongshan Hospital, Fudan University
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  organization: Radiology, Case Western Reserve University
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  organization: Radiology, University Hospitals
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  organization: Radiology, Zhongshan Hospital, Fudan University
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  organization: Siemens Shenzhen Magnetic Resonance Ltd
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/29563601$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1016/j.ejca.2005.03.005
10.1016/j.neuroimage.2004.07.051
10.1002/mrm.25665
10.3748/wjg.v16.i13.1598
10.2967/jnumed.109.064790
10.1097/RLI.0b013e31821eea45
10.1148/rg.255045180
10.1148/radiol.12110770
10.1097/RLI.0000000000000135
10.1002/cncr.26594
10.1097/RLI.0000000000000105
10.1007/s00280-012-1854-6
10.1148/radiology.218.2.r01fe10556
10.2214/ajr.176.3.1760667
10.1148/radiol.2016164030
10.1002/mrm.1910290618
10.2214/ajr.183.3.1830713
10.1002/mrm.21901
10.1097/RLI.0b013e3181caea5b
10.1002/mrm.10045
10.1038/nrclinonc.2012.2
10.1002/mrm.24980
10.1002/jmri.24238
10.1038/nrclinonc.2016.162
10.1186/1471-230X-13-53
10.1148/radiol.2483071958
10.1002/cncr.10422
10.1002/jmri.1057
10.2214/AJR.12.9798
10.1148/radiol.2343031362
10.3748/wjg.v20.i12.3125
10.1038/sj.bjc.6603515
10.1200/JCO.2003.08.092
10.1002/jmri.21429
10.1053/jlts.2002.35670
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References Abdullah (CR25) 2008; 28
Pandharipande, Krinsky, Rusinek, Lee (CR35) 2005; 234
Van Beers (CR38) 2001; 176
Ichikawa (CR2) 2010; 45
Rao, Chen, Liu, Zeng, Qu (CR16) 2013; 13
Cuenod (CR33) 2001; 218
Elsayes (CR1) 2005; 25
Chandarana (CR7) 2015; 50
O’Connor, Jackson, Parker, Jayson (CR4) 2007; 96
Chen, Shih (CR27) 2014; 20
Song (CR14) 2009; 61
Chen (CR9) 2015; 50
Feng (CR10) 2016; 75
Materne (CR12) 2002; 47
Miyazaki (CR28) 2012; 263
Feng (CR11) 2014; 72
Chen (CR29) 2016; 281
Chandarana (CR8) 2011; 46
Yokoyama (CR37) 2002; 94
Jones, Haraldseth, Muller, Rinck, Oksendal (CR13) 1993; 29
Thng, Koh, Collins, Koh (CR17) 2010; 16
O’Connor (CR6) 2017; 14
Koh (CR31) 2008; 249
Yokoyama (CR36) 2012; 118
Lin, Lunderquist, Hagerstrand, Boijsen (CR30) 1984; 96
O’Connor, Jackson, Parker, Roberts, Jayson (CR5) 2012; 9
Morgan (CR19) 2003; 21
Posey (CR21) 2003; 9
Semelka, Martin, Balci, Lance (CR3) 2001; 13
Mross (CR20) 2005; 41
Taouli (CR32) 2013; 201
Reardon (CR22) 2012; 69
Vriens (CR23) 2009; 50
Krinsky (CR34) 2002; 8
Wang, Chen, Tsang, Liu, Shih (CR18) 2004; 183
Bultman (CR15) 2014; 39
Smith (CR24) 2004; 23
Breedis, Young (CR26) 1954; 30
RC Semelka (20726_CR3) 2001; 13
SX Rao (20726_CR16) 2013; 13
B Morgan (20726_CR19) 2003; 21
C Breedis (20726_CR26) 1954; 30
N Yokoyama (20726_CR37) 2002; 94
T Song (20726_CR14) 2009; 61
SS Abdullah (20726_CR25) 2008; 28
JA Posey (20726_CR21) 2003; 9
TS Koh (20726_CR31) 2008; 249
D Vriens (20726_CR23) 2009; 50
K Miyazaki (20726_CR28) 2012; 263
DA Reardon (20726_CR22) 2012; 69
PV Pandharipande (20726_CR35) 2005; 234
BB Chen (20726_CR27) 2014; 20
K Mross (20726_CR20) 2005; 41
C Cuenod (20726_CR33) 2001; 218
L Feng (20726_CR11) 2014; 72
G Lin (20726_CR30) 1984; 96
L Feng (20726_CR10) 2016; 75
JP O’Connor (20726_CR5) 2012; 9
JP O’Connor (20726_CR6) 2017; 14
B Taouli (20726_CR32) 2013; 201
BB Chen (20726_CR29) 2016; 281
CH Thng (20726_CR17) 2010; 16
R Materne (20726_CR12) 2002; 47
EM Bultman (20726_CR15) 2014; 39
H Chandarana (20726_CR7) 2015; 50
N Yokoyama (20726_CR36) 2012; 118
JP O’Connor (20726_CR4) 2007; 96
GA Krinsky (20726_CR34) 2002; 8
BE Van Beers (20726_CR38) 2001; 176
SM Smith (20726_CR24) 2004; 23
KM Elsayes (20726_CR1) 2005; 25
J Wang (20726_CR18) 2004; 183
T Ichikawa (20726_CR2) 2010; 45
RA Jones (20726_CR13) 1993; 29
H Chandarana (20726_CR8) 2011; 46
Y Chen (20726_CR9) 2015; 50
References_xml – volume: 41
  start-page: 1291
  year: 2005
  end-page: 1299
  ident: CR20
  article-title: Phase I clinical and pharmacokinetic study of PTK/ZK, a multiple VEGF receptor inhibitor, in patients with liver metastases from solid tumours
  publication-title: European journal of cancer (Oxford, England: 1990)
  doi: 10.1016/j.ejca.2005.03.005
– volume: 23
  start-page: S208
  issue: Suppl 1
  year: 2004
  end-page: 219
  ident: CR24
  article-title: Advances in functional and structural MR image analysis and implementation as FSL
  publication-title: NeuroImage
  doi: 10.1016/j.neuroimage.2004.07.051
– volume: 96
  start-page: 517
  year: 1984
  end-page: 526
  ident: CR30
  article-title: Postmortem examination of the blood supply and vascular pattern of small liver metastases in man
  publication-title: Surgery
– volume: 75
  start-page: 775
  year: 2016
  end-page: 788
  ident: CR10
  article-title: XD-GRASP: Golden-angle radial MRI with reconstruction of extra motion-state dimensions using compressed sensing
  publication-title: Magn Reson Med
  doi: 10.1002/mrm.25665
– volume: 16
  start-page: 1598
  year: 2010
  end-page: 1609
  ident: CR17
  article-title: Perfusion magnetic resonance imaging of the liver
  publication-title: World journal of gastroenterology
  doi: 10.3748/wjg.v16.i13.1598
– volume: 9
  start-page: 1323
  year: 2003
  end-page: 1332
  ident: CR21
  article-title: A phase I study of anti-kinase insert domain-containing receptor antibody, IMC-1C11, in patients with liver metastases from colorectal carcinoma
  publication-title: Clinical cancer research: an official journal of the American Association for Cancer Research
– volume: 50
  start-page: 1777
  year: 2009
  end-page: 1784
  ident: CR23
  article-title: Chemotherapy response monitoring of colorectal liver metastases by dynamic Gd-DTPA-enhanced MRI perfusion parameters and 18F-FDG PET metabolic rate
  publication-title: Journal of nuclear medicine: official publication, Society of Nuclear Medicine
  doi: 10.2967/jnumed.109.064790
– volume: 46
  start-page: 648
  year: 2011
  end-page: 653
  ident: CR8
  article-title: Free-breathing radial 3D fat-suppressed T1-weighted gradient echo sequence: a viable alternative for contrast-enhanced liver imaging in patients unable to suspend respiration
  publication-title: Investigative radiology
  doi: 10.1097/RLI.0b013e31821eea45
– volume: 25
  start-page: 1299
  year: 2005
  end-page: 1320
  ident: CR1
  article-title: Focal hepatic lesions: diagnostic value of enhancement pattern approach with contrast-enhanced 3D gradient-echo MR imaging
  publication-title: Radiographics
  doi: 10.1148/rg.255045180
– volume: 263
  start-page: 139
  year: 2012
  end-page: 148
  ident: CR28
  article-title: Neuroendocrine tumor liver metastases: use of dynamic contrast-enhanced MR imaging to monitor and predict radiolabeled octreotide therapy response
  publication-title: Radiology
  doi: 10.1148/radiol.12110770
– volume: 50
  start-page: 367
  year: 2015
  end-page: 375
  ident: CR9
  article-title: Free-breathing liver perfusion imaging using 3-dimensional through-time spiral generalized autocalibrating partially parallel acquisition acceleration
  publication-title: Investigative radiology
  doi: 10.1097/RLI.0000000000000135
– volume: 30
  start-page: 969
  year: 1954
  end-page: 977
  ident: CR26
  article-title: The blood supply of neoplasms in the liver
  publication-title: The American journal of pathology
– volume: 118
  start-page: 2813
  year: 2012
  end-page: 2819
  ident: CR36
  article-title: Real-time detection of hepatic micrometastases from pancreatic cancer by intraoperative fluorescence imaging: preliminary results of a prospective study
  publication-title: Cancer
  doi: 10.1002/cncr.26594
– volume: 50
  start-page: 88
  year: 2015
  end-page: 94
  ident: CR7
  article-title: Estimating liver perfusion from free-breathing continuously acquired dynamic gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid-enhanced acquisition with compressed sensing reconstruction
  publication-title: Investigative radiology
  doi: 10.1097/RLI.0000000000000105
– volume: 69
  start-page: 1507
  year: 2012
  end-page: 1518
  ident: CR22
  article-title: Phase I study of AEE788, a novel multitarget inhibitor of ErbB- and VEGF-receptor-family tyrosine kinases, in recurrent glioblastoma patients
  publication-title: Cancer chemotherapy and pharmacology
  doi: 10.1007/s00280-012-1854-6
– volume: 218
  start-page: 556
  year: 2001
  end-page: 561
  ident: CR33
  article-title: Early changes in liver perfusion caused by occult metastases in rats: detection with quantitative CT
  publication-title: Radiology
  doi: 10.1148/radiology.218.2.r01fe10556
– volume: 176
  start-page: 667
  year: 2001
  end-page: 673
  ident: CR38
  article-title: Hepatic perfusion parameters in chronic liver disease: dynamic CT measurements correlated with disease severity
  publication-title: AJR. American journal of roentgenology
  doi: 10.2214/ajr.176.3.1760667
– volume: 281
  start-page: 983
  year: 2016
  ident: CR29
  article-title: Dynamic Contrast-enhanced MR Imaging of Advanced Hepatocellular Carcinoma: Comparison with the Liver Parenchyma and Correlation with the Survival of Patients Receiving Systemic Therapy
  publication-title: Radiology
  doi: 10.1148/radiol.2016164030
– volume: 29
  start-page: 830
  year: 1993
  end-page: 834
  ident: CR13
  article-title: K-space substitution: a novel dynamic imaging technique
  publication-title: Magn Reson Med
  doi: 10.1002/mrm.1910290618
– volume: 183
  start-page: 713
  year: 2004
  end-page: 719
  ident: CR18
  article-title: Dynamic contrast-enhanced MRI analysis of perfusion changes in advanced hepatocellular carcinoma treated with an antiangiogenic agent: a preliminary study
  publication-title: AJR. American journal of roentgenology
  doi: 10.2214/ajr.183.3.1830713
– volume: 61
  start-page: 1242
  year: 2009
  end-page: 1248
  ident: CR14
  article-title: Optimal k-space sampling for dynamic contrast-enhanced MRI with an application to MR renography
  publication-title: Magn Reson Med
  doi: 10.1002/mrm.21901
– volume: 45
  start-page: 133
  year: 2010
  end-page: 141
  ident: CR2
  article-title: Detection and characterization of focal liver lesions: a Japanese phase III, multicenter comparison between gadoxetic acid disodium-enhanced magnetic resonance imaging and contrast-enhanced computed tomography predominantly in patients with hepatocellular carcinoma and chronic liver disease
  publication-title: Investigative radiology
  doi: 10.1097/RLI.0b013e3181caea5b
– volume: 47
  start-page: 135
  year: 2002
  end-page: 142
  ident: CR12
  article-title: Assessment of hepatic perfusion parameters with dynamic MRI
  publication-title: Magn Reson Med
  doi: 10.1002/mrm.10045
– volume: 9
  start-page: 167
  year: 2012
  end-page: 177
  ident: CR5
  article-title: Dynamic contrast-enhanced MRI in clinical trials of antivascular therapies
  publication-title: Nature reviews. Clinical oncology
  doi: 10.1038/nrclinonc.2012.2
– volume: 72
  start-page: 707
  year: 2014
  end-page: 717
  ident: CR11
  article-title: Golden-angle radial sparse parallel MRI: combination of compressed sensing, parallel imaging, and golden-angle radial sampling for fast and flexible dynamic volumetric MRI
  publication-title: Magn Reson Med
  doi: 10.1002/mrm.24980
– volume: 39
  start-page: 853
  year: 2014
  end-page: 865
  ident: CR15
  article-title: Quantitative hepatic perfusion modeling using DCE-MRI with sequential breathholds
  publication-title: Journal of magnetic resonance imaging: JMRI
  doi: 10.1002/jmri.24238
– volume: 14
  start-page: 169
  year: 2017
  end-page: 186
  ident: CR6
  article-title: Imaging biomarker roadmap for cancer studies
  publication-title: Nature reviews. Clinical oncology
  doi: 10.1038/nrclinonc.2016.162
– volume: 13
  year: 2013
  ident: CR16
  article-title: Three-dimensional whole-liver perfusion magnetic resonance imaging in patients with hepatocellular carcinomas and colorectal hepatic metastases
  publication-title: BMC gastroenterology
  doi: 10.1186/1471-230X-13-53
– volume: 249
  start-page: 307
  year: 2008
  end-page: 320
  ident: CR31
  article-title: Hepatic metastases: assessment of perfusion parameters at dynamic contrast-enhanced MR imaging with dual-input two-compartment tracer kinetics model
  publication-title: Radiology
  doi: 10.1148/radiol.2483071958
– volume: 94
  start-page: 1642
  year: 2002
  end-page: 1647
  ident: CR37
  article-title: Immunohistochemically detected hepatic micrometastases predict a high risk of intrahepatic recurrence after resection of colorectal carcinoma liver metastases
  publication-title: Cancer
  doi: 10.1002/cncr.10422
– volume: 13
  start-page: 397
  year: 2001
  end-page: 401
  ident: CR3
  article-title: Focal liver lesions: comparison of dual-phase CT and multisequence multiplanar MR imaging including dynamic gadolinium enhancement
  publication-title: Journal of magnetic resonance imaging: JMRI
  doi: 10.1002/jmri.1057
– volume: 201
  start-page: 795
  year: 2013
  end-page: 800
  ident: CR32
  article-title: Hepatocellular carcinoma: perfusion quantification with dynamic contrast-enhanced MRI
  publication-title: AJR. American journal of roentgenology
  doi: 10.2214/AJR.12.9798
– volume: 234
  start-page: 661
  year: 2005
  end-page: 673
  ident: CR35
  article-title: Perfusion imaging of the liver: current challenges and future goals
  publication-title: Radiology
  doi: 10.1148/radiol.2343031362
– volume: 20
  start-page: 3125
  year: 2014
  end-page: 3134
  ident: CR27
  article-title: DCE-MRI in hepatocellular carcinoma-clinical and therapeutic image biomarker
  publication-title: World journal of gastroenterology
  doi: 10.3748/wjg.v20.i12.3125
– volume: 96
  start-page: 189
  year: 2007
  end-page: 195
  ident: CR4
  article-title: DCE-MRI biomarkers in the clinical evaluation of antiangiogenic and vascular disrupting agents
  publication-title: British journal of cancer
  doi: 10.1038/sj.bjc.6603515
– volume: 21
  start-page: 3955
  year: 2003
  end-page: 3964
  ident: CR19
  article-title: Dynamic contrast-enhanced magnetic resonance imaging as a biomarker for the pharmacological response of PTK787/ZK 222584, an inhibitor of the vascular endothelial growth factor receptor tyrosine kinases, in patients with advanced colorectal cancer and liver metastases: results from two phase I studies
  publication-title: Journal of clinical oncology: official journal of the American Society of Clinical Oncology
  doi: 10.1200/JCO.2003.08.092
– volume: 28
  start-page: 390
  year: 2008
  end-page: 395
  ident: CR25
  article-title: Characterization of hepatocellular carcinoma and colorectal liver metastasis by means of perfusion MRI
  publication-title: Journal of magnetic resonance imaging: JMRI
  doi: 10.1002/jmri.21429
– volume: 8
  start-page: 1156
  year: 2002
  end-page: 1164
  ident: CR34
  article-title: Transplantation for hepatocellular carcinoma and cirrhosis: sensitivity of magnetic resonance imaging
  publication-title: Liver transplantation: official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
  doi: 10.1053/jlts.2002.35670
– volume: 25
  start-page: 1299
  year: 2005
  ident: 20726_CR1
  publication-title: Radiographics
  doi: 10.1148/rg.255045180
– volume: 13
  start-page: 397
  year: 2001
  ident: 20726_CR3
  publication-title: Journal of magnetic resonance imaging: JMRI
  doi: 10.1002/jmri.1057
– volume: 16
  start-page: 1598
  year: 2010
  ident: 20726_CR17
  publication-title: World journal of gastroenterology
  doi: 10.3748/wjg.v16.i13.1598
– volume: 14
  start-page: 169
  year: 2017
  ident: 20726_CR6
  publication-title: Nature reviews. Clinical oncology
  doi: 10.1038/nrclinonc.2016.162
– volume: 9
  start-page: 1323
  year: 2003
  ident: 20726_CR21
  publication-title: Clinical cancer research: an official journal of the American Association for Cancer Research
– volume: 21
  start-page: 3955
  year: 2003
  ident: 20726_CR19
  publication-title: Journal of clinical oncology: official journal of the American Society of Clinical Oncology
  doi: 10.1200/JCO.2003.08.092
– volume: 46
  start-page: 648
  year: 2011
  ident: 20726_CR8
  publication-title: Investigative radiology
  doi: 10.1097/RLI.0b013e31821eea45
– volume: 72
  start-page: 707
  year: 2014
  ident: 20726_CR11
  publication-title: Magn Reson Med
  doi: 10.1002/mrm.24980
– volume: 28
  start-page: 390
  year: 2008
  ident: 20726_CR25
  publication-title: Journal of magnetic resonance imaging: JMRI
  doi: 10.1002/jmri.21429
– volume: 8
  start-page: 1156
  year: 2002
  ident: 20726_CR34
  publication-title: Liver transplantation: official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
  doi: 10.1053/jlts.2002.35670
– volume: 9
  start-page: 167
  year: 2012
  ident: 20726_CR5
  publication-title: Nature reviews. Clinical oncology
  doi: 10.1038/nrclinonc.2012.2
– volume: 94
  start-page: 1642
  year: 2002
  ident: 20726_CR37
  publication-title: Cancer
  doi: 10.1002/cncr.10422
– volume: 13
  year: 2013
  ident: 20726_CR16
  publication-title: BMC gastroenterology
  doi: 10.1186/1471-230X-13-53
– volume: 47
  start-page: 135
  year: 2002
  ident: 20726_CR12
  publication-title: Magn Reson Med
  doi: 10.1002/mrm.10045
– volume: 41
  start-page: 1291
  year: 2005
  ident: 20726_CR20
  publication-title: European journal of cancer (Oxford, England: 1990)
  doi: 10.1016/j.ejca.2005.03.005
– volume: 118
  start-page: 2813
  year: 2012
  ident: 20726_CR36
  publication-title: Cancer
  doi: 10.1002/cncr.26594
– volume: 176
  start-page: 667
  year: 2001
  ident: 20726_CR38
  publication-title: AJR. American journal of roentgenology
  doi: 10.2214/ajr.176.3.1760667
– volume: 183
  start-page: 713
  year: 2004
  ident: 20726_CR18
  publication-title: AJR. American journal of roentgenology
  doi: 10.2214/ajr.183.3.1830713
– volume: 249
  start-page: 307
  year: 2008
  ident: 20726_CR31
  publication-title: Radiology
  doi: 10.1148/radiol.2483071958
– volume: 50
  start-page: 88
  year: 2015
  ident: 20726_CR7
  publication-title: Investigative radiology
  doi: 10.1097/RLI.0000000000000105
– volume: 201
  start-page: 795
  year: 2013
  ident: 20726_CR32
  publication-title: AJR. American journal of roentgenology
  doi: 10.2214/AJR.12.9798
– volume: 75
  start-page: 775
  year: 2016
  ident: 20726_CR10
  publication-title: Magn Reson Med
  doi: 10.1002/mrm.25665
– volume: 29
  start-page: 830
  year: 1993
  ident: 20726_CR13
  publication-title: Magn Reson Med
  doi: 10.1002/mrm.1910290618
– volume: 23
  start-page: S208
  issue: Suppl 1
  year: 2004
  ident: 20726_CR24
  publication-title: NeuroImage
  doi: 10.1016/j.neuroimage.2004.07.051
– volume: 20
  start-page: 3125
  year: 2014
  ident: 20726_CR27
  publication-title: World journal of gastroenterology
  doi: 10.3748/wjg.v20.i12.3125
– volume: 30
  start-page: 969
  year: 1954
  ident: 20726_CR26
  publication-title: The American journal of pathology
– volume: 39
  start-page: 853
  year: 2014
  ident: 20726_CR15
  publication-title: Journal of magnetic resonance imaging: JMRI
  doi: 10.1002/jmri.24238
– volume: 45
  start-page: 133
  year: 2010
  ident: 20726_CR2
  publication-title: Investigative radiology
  doi: 10.1097/RLI.0b013e3181caea5b
– volume: 61
  start-page: 1242
  year: 2009
  ident: 20726_CR14
  publication-title: Magn Reson Med
  doi: 10.1002/mrm.21901
– volume: 281
  start-page: 983
  year: 2016
  ident: 20726_CR29
  publication-title: Radiology
  doi: 10.1148/radiol.2016164030
– volume: 96
  start-page: 517
  year: 1984
  ident: 20726_CR30
  publication-title: Surgery
– volume: 50
  start-page: 1777
  year: 2009
  ident: 20726_CR23
  publication-title: Journal of nuclear medicine: official publication, Society of Nuclear Medicine
  doi: 10.2967/jnumed.109.064790
– volume: 263
  start-page: 139
  year: 2012
  ident: 20726_CR28
  publication-title: Radiology
  doi: 10.1148/radiol.12110770
– volume: 69
  start-page: 1507
  year: 2012
  ident: 20726_CR22
  publication-title: Cancer chemotherapy and pharmacology
  doi: 10.1007/s00280-012-1854-6
– volume: 96
  start-page: 189
  year: 2007
  ident: 20726_CR4
  publication-title: British journal of cancer
  doi: 10.1038/sj.bjc.6603515
– volume: 234
  start-page: 661
  year: 2005
  ident: 20726_CR35
  publication-title: Radiology
  doi: 10.1148/radiol.2343031362
– volume: 218
  start-page: 556
  year: 2001
  ident: 20726_CR33
  publication-title: Radiology
  doi: 10.1148/radiology.218.2.r01fe10556
– volume: 50
  start-page: 367
  year: 2015
  ident: 20726_CR9
  publication-title: Investigative radiology
  doi: 10.1097/RLI.0000000000000135
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Snippet We describe multi-institutional experience using free-breathing, 3D Spiral GRAPPA-based quantitative perfusion MRI in characterizing neoplastic liver masses....
Abstract We describe multi-institutional experience using free-breathing, 3D Spiral GRAPPA-based quantitative perfusion MRI in characterizing neoplastic liver...
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692/308/575
692/700/1421/1628
Hepatocellular carcinoma
Humanities and Social Sciences
Lesions
Liver
Liver cancer
Magnetic resonance imaging
Metastases
Metastasis
multidisciplinary
Parenchyma
Perfusion
Respiration
Science
Science (multidisciplinary)
Statistical analysis
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Title Quantitative perfusion imaging of neoplastic liver lesions: A multi-institution study
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