Associations of genetically predicted IL-6 signaling with cardiovascular disease risk across population subgroups

Background Interleukin 6 (IL-6) signaling is being investigated as a therapeutic target for atherosclerotic cardiovascular disease (CVD). While changes in circulating high-sensitivity C-reactive protein (hsCRP) are used as a marker of IL-6 signaling, it is not known whether there is effect heterogen...

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Bibliographic Details
Published in:	BMC medicine Vol. 20; no. 1; pp. 245 - 7
Main Authors:	Georgakis, Marios K., Malik, Rainer, Richardson, Tom G., Howson, Joanna M. M., Anderson, Christopher D., Burgess, Stephen, Hovingh, G. Kees, Dichgans, Martin, Gill, Dipender
Format:	Journal Article
Language:	English
Published:	London BioMed Central 11.08.2022 Springer Nature B.V BMC
Subjects:	Aorta Aortic aneurysms Arteriosclerosis Atherosclerosis Biobanks Biomarkers Biomedicine Blood pressure Body mass Body mass index Body size C-reactive protein C-Reactive Protein - metabolism Cardiovascular disease Cardiovascular diseases Cardiovascular Diseases - epidemiology Cardiovascular Diseases - genetics Cholesterol Cholesterol, LDL Coronary artery Coronary artery disease Cytokines Drug dosages Epidemiology Estimates Female Females Glomerular filtration rate Health risk assessment Health risks Heart diseases Heterogeneity Humans Inflammation Interleukin 6 Interleukin 6 receptors Interleukin-6 - genetics Ischemia Male Medicine Medicine & Public Health Middle Aged Population Research Article Risk analysis Risk Factors Risk management Signaling Subgroups Therapeutic targets Thrombosis Vascular diseases Vein & artery diseases United Kingdom > UK C-reactive protein Cytokines Atherosclerosis Cardiovascular disease Inflammation Mendelian randomization Human genetics Interleukin-6
ISSN:	1741-7015, 1741-7015
Online Access:	Get full text
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