The Zscan4-Tet2 Transcription Nexus Regulates Metabolic Rewiring and Enhances Proteostasis to Promote Reprogramming

Evolutionarily conserved SCAN (named after SRE-ZBP, CTfin51, AW-1, and Number 18 cDNA)-domain-containing zinc finger transcription factors (ZSCAN) have been found in both mouse and human genomes. Zscan4 is transiently expressed during zygotic genome activation (ZGA) in preimplantation embryos and in...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cell reports (Cambridge) Jg. 32; H. 2; S. 107877
Hauptverfasser:	Cheng, Zhou-Li, Zhang, Meng-Li, Lin, Huai-Peng, Gao, Chao, Song, Jun-Bin, Zheng, Zhihong, Li, Linpeng, Zhang, Yanan, Shen, Xiaoqi, Zhang, Hao, Huang, Zhenghui, Zhan, Wuqiang, Zhang, Cheng, Hu, Xu, Sun, Yi-Ping, Jiang, Lubing, Sun, Lei, Xu, Yanhui, Yang, Chen, Ge, Yuanlong, Zhao, Yong, Liu, Xingguo, Yang, Hui, Liu, Pengyuan, Guo, Xing, Guan, Kun-Liang, Xiong, Yue, Zhang, Mingliang, Ye, Dan
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Elsevier Inc 14.07.2020 Elsevier
Schlagworte:	Animals Base Sequence Cellular Reprogramming - genetics DNA - metabolism DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Glycolysis - genetics HEK293 Cells Humans induced pluripotent stem cells Induced Pluripotent Stem Cells - metabolism iPSCs MCF-7 Cells metabolic rewiring Mice, Inbred C57BL Proteasome Endopeptidase Complex - metabolism proteasome function Protein Binding Protein Domains Proteostasis - genetics Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism SCAN domain stem cell potency TET2 Transcription Factors - metabolism Transcription, Genetic Up-Regulation ZSCAN4 metabolic rewiring iPSCs SCAN domain proteasome function stem cell potency ZSCAN4 TET2 induced pluripotent stem cells
ISSN:	2211-1247, 2211-1247
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!