Fundamental aspects of long-acting tenofovir alafenamide delivery from subdermal implants for HIV prophylaxis

Global efforts aimed at preventing human immunodeficiency virus type one (HIV-1) infection in vulnerable populations appear to be stalling, limiting our ability to control the epidemic. Long-acting, controlled drug administration from subdermal implants holds significant potential by reducing the co...

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Veröffentlicht in:	Scientific reports Jg. 12; H. 1; S. 8224 - 25
Hauptverfasser:	Gunawardana, Manjula, Remedios-Chan, Mariana, Sanchez, Debbie, Webster, Simon, Castonguay, Amalia E., Webster, Paul, Buser, Christopher, Moss, John A., Trinh, MyMy, Beliveau, Martin, Hendrix, Craig W., Marzinke, Mark A., Tuck, Michael, Caprioli, Richard M., Reyzer, Michelle L., Kuo, Joseph, Gallay, Philippe A., Baum, Marc M.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 17.05.2022 Nature Publishing Group Nature Portfolio
Schlagworte:	631/154/152 692/308/153 Adenine Alanine - therapeutic use Animal models Animals Anti-HIV Agents Antiretroviral drugs At risk populations Dosage Drug dosages Female HIV HIV Infections - drug therapy HIV Infections - prevention & control Human immunodeficiency virus Humanities and Social Sciences Mass spectrometry Mass spectroscopy Metabolites Mice multidisciplinary Pharmacokinetics Pharmacology Prophylaxis Science Science (multidisciplinary) Spatial distribution Tenofovir Tenofovir - analogs & derivatives Tenofovir - therapeutic use Transplants & implants
ISSN:	2045-2322, 2045-2322
Online-Zugang:	Volltext
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