A functional genomics pipeline identifies pleiotropy and cross-tissue effects within obesity-associated GWAS loci

Genome-wide association studies (GWAS) have identified many disease-associated variants, yet mechanisms underlying these associations remain unclear. To understand obesity-associated variants, we generate gene regulatory annotations in adipocytes and hypothalamic neurons across cellular differentiat...

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Bibliographic Details
Published in:	Nature communications Vol. 12; no. 1; pp. 5253 - 15
Main Authors:	Joslin, Amelia C., Sobreira, Débora R., Hansen, Grace T., Sakabe, Noboru J., Aneas, Ivy, Montefiori, Lindsey E., Farris, Kathryn M., Gu, Jing, Lehman, Donna M., Ober, Carole, He, Xin, Nóbrega, Marcelo A.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 06.09.2021 Nature Publishing Group Nature Portfolio
Subjects:	13/100 38/109 38/47 38/91 45/43 45/77 49/22 49/31 49/90 631/208/191 631/208/200 631/208/212/177 692/699/2743/393 Adipocytes Adipocytes - cytology Adipocytes - physiology Annotations Arrhythmias, Cardiac - genetics Arrhythmias, Cardiac - pathology Chromatin Differentiation (biology) Enhancer Elements, Genetic Gene expression Gene loci Genes Genetic Diseases, X-Linked - genetics Genetic Diseases, X-Linked - pathology Genetic Pleiotropy Genome-wide association studies Genome-Wide Association Study Genomics Gigantism - genetics Gigantism - pathology Heart Defects, Congenital - genetics Heart Defects, Congenital - pathology Humanities and Social Sciences Humans Hypothalamus Hypothalamus - physiology Intellectual Disability - genetics Intellectual Disability - pathology MAP Kinase Kinase 5 - genetics multidisciplinary Neurons - cytology Neurons - physiology Obesity Obesity - genetics Pleiotropy Polymorphism, Single Nucleotide Protein Kinases - genetics Quantitative Trait Loci Sarcoplasmic Reticulum Calcium-Transporting ATPases - genetics Science Science (multidisciplinary) Transcription Factors - genetics Transcriptome
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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