Pharmacodynamic Evaluation of Dosing, Bacterial Kill, and Resistance Suppression for Zoliflodacin Against Neisseria gonorrhoeae in a Dynamic Hollow Fiber Infection Model

Antimicrobial resistance in Neisseria gonorrhoeae is threatening the treatment and control of gonorrhea globally, and new treatment options are imperative. Utilizing our dynamic in vitro hollow fiber infection model (HFIM), we examined the pharmacodynamics of the first-in-class spiropyrimidinetrione...

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Veröffentlicht in:	Frontiers in pharmacology Jg. 12; S. 682135
Hauptverfasser:	Jacobsson, Susanne, Golparian, Daniel, Oxelbark, Joakim, Alirol, Emilie, Franceschi, Francois, Gustafsson, Tomas N., Brown, David, Louie, Arnold, Drusano, George, Unemo, Magnus
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Switzerland Frontiers Media S.A 21.05.2021
Schlagworte:	antimicrobial treatment hollow fiber infection model Neisseria gonorrhoeae pharmacodynamics pharmacokinetics Pharmacology zoliflodacin pharmacokinetics hollow fiber infection model Neisseria gonorrhoeae zoliflodacin pharmacodynamics antimicrobial treatment
ISSN:	1663-9812, 1663-9812
Online-Zugang:	Volltext
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