Genetic and pharmacologic inhibition of ALDH1A3 as a treatment of β-cell failure

Type 2 diabetes (T2D) is associated with β-cell dedifferentiation. Aldehyde dehydrogenase 1 isoform A3 (ALHD1A3) is a marker of β-cell dedifferentiation and correlates with T2D progression. However, it is unknown whether ALDH1A3 activity contributes to β-cell failure, and whether the decrease of ALD...

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Bibliographic Details
Published in:	Nature communications Vol. 14; no. 1; pp. 558 - 14
Main Authors:	Son, Jinsook, Du, Wen, Esposito, Mark, Shariati, Kaavian, Ding, Hongxu, Kang, Yibin, Accili, Domenico
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 02.02.2023 Nature Publishing Group Nature Portfolio
Subjects:	13/106 13/31 13/51 14/19 38 38/91 42 45 631/136/142 631/136/2435 631/443/319/1642/137/773 631/80/304 64 64/60 Ablation Aldehyde dehydrogenase Aldehyde Dehydrogenase 1 Family Aldehyde Oxidoreductases - metabolism Aldehydes Animals Beta cells Blood glucose Cell differentiation Cell Line, Tumor Diabetes Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Experimental - drug therapy Diabetes Mellitus, Experimental - genetics Diabetes Mellitus, Type 2 - drug therapy Diabetes Mellitus, Type 2 - genetics Humanities and Social Sciences Insulin Insulin secretion Insulin-Secreting Cells - metabolism Mice multidisciplinary Pharmacology Science Science (multidisciplinary) Tracing
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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