Immune effects of PI3K/Akt/HIF-1α-regulated glycolysis in polymorphonuclear neutrophils during sepsis

Background Effective removal of pathogenic bacteria is key to improving the prognosis of sepsis. Polymorphonuclear neutrophils (PMNs) are the most important components of innate cellular immunity and play vital roles in clearing pathogenic bacteria. However, the metabolic characteristics and immunom...

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Bibliographic Details
Published in:	Critical care (London, England) Vol. 26; no. 1; pp. 29 - 17
Main Authors:	Pan, Tingting, Sun, Shaoqiong, Chen, Yang, Tian, Rui, Chen, Erzhen, Tan, Ruoming, Wang, Xiaoli, Liu, Zhaojun, Liu, Jialin, Qu, Hongping
Format:	Journal Article
Language:	English
Published:	London BioMed Central 28.01.2022 Springer Nature B.V BMC
Subjects:	Antibodies Bacteria Chromatography Critical care Critical Care Medicine Discriminant analysis Emergency Medicine Glycolysis Humans Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Immune Infections Intensive Mass spectrometry Medicine Medicine & Public Health Metabolism Metabolites Metabolomics Neutrophil Neutrophils Neutrophils - metabolism Phosphatidylinositol 3-Kinases - metabolism Proto-Oncogene Proteins c-akt - metabolism Scientific imaging Sepsis Signal Transduction St Louis Missouri United States > US Norway China Germany Glycolysis Metabolomics Sepsis Neutrophil Immune
ISSN:	1364-8535, 1466-609X, 1364-8535, 1466-609X, 1366-609X
Online Access:	Get full text
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