Axial length and its associations in the Ural Very Old Study

To assess the distribution of axial length as surrogate for myopia and its determinants in an old population, we performed the Ural Very Old Study as a population-based cohort study. Out of 1882 eligible individuals aged 85 + years, the Ural Very Old Study performed in an urban and rural region in B...

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Veröffentlicht in:Scientific reports Jg. 11; H. 1; S. 18459 - 8
Hauptverfasser: Bikbov, Mukharram M., Kazakbaeva, Gyulli M., Rakhimova, Ellina M., Rusakova, Iuliia A., Fakhretdinova, Albina A., Tuliakova, Azaliia M., Panda-Jonas, Songhomitra, Gilmanshin, Timur R., Zainullin, Rinat M., Bolshakova, Natalia I., Safiullina, Kamilia R., Gizzatov, Ainur V., Ponomarev, Ildar P., Yakupova, Dilya F., Baymukhametov, Nail E., Nikitin, Nikolay A., Jonas, Jost B.
Format: Journal Article
Sprache:Englisch
Veröffentlicht: London Nature Publishing Group UK 16.09.2021
Nature Publishing Group
Nature Portfolio
Schlagworte:
692/698
692/698/1688
692/698/1688/512
692/698/1688/512/2613
692/698/1688/512/2613/2616
692/699
692/699/3161
692/699/3161/3174
Aged, 80 and over
Axial Length, Eye - anatomy & histology
Axial Length, Eye - growth & development
Body height
Cornea
Female
Geriatric Assessment - statistics & numerical data
Humanities and Social Sciences
Humans
Male
multidisciplinary
Myopia
Myopia - epidemiology
Population
Population studies
Rural areas
Science
Science (multidisciplinary)
ISSN:2045-2322, 2045-2322
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Zusammenfassung:To assess the distribution of axial length as surrogate for myopia and its determinants in an old population, we performed the Ural Very Old Study as a population-based cohort study. Out of 1882 eligible individuals aged 85 + years, the Ural Very Old Study performed in an urban and rural region in Bashkortostan/Russia included 1526 (81.1%) individuals undergoing ophthalmological and medical examinations with sonographic axial length measurement. Biometric data were available for 717 (47.0%) individuals with a mean age of 88.0 ± 2.6 years (range 85–98 years; 25%). Mean axial length was 23.1 ± 1.1 mm (range 19.37–28.89 mm). Prevalences of moderate myopia (axial length 24.5–< 26.5 mm) and high myopia (axial length ≥ 26.5 mm) were 47/717 (6.6%; 95% CI 4.7, 8.4) and 10/717 (1.4%; 95% CI 0.5, 2.3), respectively. In multivariable analysis, longer axial length was associated (coefficient of determination r 2 0.25) with taller body height (standardized regression coefficient beta:0.16;non-standardized regression coefficient B: 0.02; 95% confidence interval (CI) 0.01, 0.03; P  < 0.001), higher level of education (beta: 0.12; B: 0.07; 95% CI 0.02, 0.11; P  = 0.002), and lower corneal refractive power (beta: − 0.35; B: − 0.23; 95% CI − 0.28, − 0.18; P  < 0.001). Higher prevalence of moderate myopia, however not of high myopia, was associated with higher educational level (OR 1.39; 95% CI 1.09, 1.68; P  = 0.007) and lower corneal refractive power (OR 0.77; 95% CI 0.63, 0.94; P  = 0.01). In this old study population, prevalence of moderate axial myopia (6.6% versus 9.7%) was lower than, and prevalence of high axial myopia (1.4% versus 1.4%) was similar as, in a corresponding study on a younger population from the same Russian region. Both myopia prevalence rates were higher than in rural Central India (1.5% and 0.4%, respectively). As in other, younger, populations, axial length and moderate myopia prevalence increased with higher educational level, while high myopia prevalence was independent of the educational level.
Bibliographie:ObjectType-Article-1
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ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-021-98039-z