Optimal deep brain stimulation sites and networks for stimulation of the fornix in Alzheimer’s disease

Deep brain stimulation (DBS) to the fornix is an investigational treatment for patients with mild Alzheimer’s Disease. Outcomes from randomized clinical trials have shown that cognitive function improved in some patients but deteriorated in others. This could be explained by variance in electrode pl...

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Bibliographic Details
Published in:	Nature communications Vol. 13; no. 1; pp. 7707 - 14
Main Authors:	Ríos, Ana Sofía, Oxenford, Simón, Neudorfer, Clemens, Butenko, Konstantin, Li, Ningfei, Rajamani, Nanditha, Boutet, Alexandre, Elias, Gavin J. B., Germann, Jurgen, Loh, Aaron, Deeb, Wissam, Wang, Fuyixue, Setsompop, Kawin, Salvato, Bryan, Almeida, Leonardo Brito de, Foote, Kelly D., Amaral, Robert, Rosenberg, Paul B., Tang-Wai, David F., Wolk, David A., Burke, Anna D., Salloway, Stephen, Sabbagh, Marwan N., Chakravarty, M. Mallar, Smith, Gwenn S., Lyketsos, Constantine G., Okun, Michael S., Anderson, William S., Mari, Zoltan, Ponce, Francisco A., Lozano, Andres M., Horn, Andreas
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 14.12.2022 Nature Publishing Group Nature Portfolio
Subjects:	59 59/36 59/57 692/308/575 692/699/375/132/1283 Alzheimer Disease - therapy Alzheimer's disease Brain Brain - diagnostic imaging Circuits Clinical trials Cognitive ability Deep Brain Stimulation Fornix Fornix, Brain - diagnostic imaging Fornix, Brain - physiology Health services Humanities and Social Sciences Humans multidisciplinary Neural networks Neurodegenerative diseases Patients Randomized Controlled Trials as Topic Science Science (multidisciplinary) Stimulation Stria terminalis Structure-function relationships Thalamus
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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