Optimal deep brain stimulation sites and networks for stimulation of the fornix in Alzheimer’s disease

Deep brain stimulation (DBS) to the fornix is an investigational treatment for patients with mild Alzheimer’s Disease. Outcomes from randomized clinical trials have shown that cognitive function improved in some patients but deteriorated in others. This could be explained by variance in electrode pl...

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Veröffentlicht in:Nature communications Jg. 13; H. 1; S. 7707 - 14
Hauptverfasser: Ríos, Ana Sofía, Oxenford, Simón, Neudorfer, Clemens, Butenko, Konstantin, Li, Ningfei, Rajamani, Nanditha, Boutet, Alexandre, Elias, Gavin J. B., Germann, Jurgen, Loh, Aaron, Deeb, Wissam, Wang, Fuyixue, Setsompop, Kawin, Salvato, Bryan, Almeida, Leonardo Brito de, Foote, Kelly D., Amaral, Robert, Rosenberg, Paul B., Tang-Wai, David F., Wolk, David A., Burke, Anna D., Salloway, Stephen, Sabbagh, Marwan N., Chakravarty, M. Mallar, Smith, Gwenn S., Lyketsos, Constantine G., Okun, Michael S., Anderson, William S., Mari, Zoltan, Ponce, Francisco A., Lozano, Andres M., Horn, Andreas
Format: Journal Article
Sprache:Englisch
Veröffentlicht: London Nature Publishing Group UK 14.12.2022
Nature Publishing Group
Nature Portfolio
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59
59/36
59/57
692/308/575
692/699/375/132/1283
Alzheimer Disease - therapy
Alzheimer's disease
Brain
Brain - diagnostic imaging
Circuits
Clinical trials
Cognitive ability
Deep Brain Stimulation
Fornix
Fornix, Brain - diagnostic imaging
Fornix, Brain - physiology
Health services
Humanities and Social Sciences
Humans
multidisciplinary
Neural networks
Neurodegenerative diseases
Patients
Randomized Controlled Trials as Topic
Science
Science (multidisciplinary)
Stimulation
Stria terminalis
Structure-function relationships
Thalamus
ISSN:2041-1723, 2041-1723
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Abstract Deep brain stimulation (DBS) to the fornix is an investigational treatment for patients with mild Alzheimer’s Disease. Outcomes from randomized clinical trials have shown that cognitive function improved in some patients but deteriorated in others. This could be explained by variance in electrode placement leading to differential engagement of neural circuits. To investigate this, we performed a post-hoc analysis on a multi-center cohort of 46 patients with DBS to the fornix (NCT00658125, NCT01608061). Using normative structural and functional connectivity data, we found that stimulation of the circuit of Papez and stria terminalis robustly associated with cognitive improvement ( R  = 0.53, p  < 0.001). On a local level, the optimal stimulation site resided at the direct interface between these structures ( R  = 0.48, p  < 0.001). Finally, modulating specific distributed brain networks related to memory accounted for optimal outcomes ( R  = 0.48, p  < 0.001). Findings were robust to multiple cross-validation designs and may define an optimal network target that could refine DBS surgery and programming. Deep brain stimulation has been investigated as a potential treatment for cognitive impairments in Alzheimer’s disease. Here the authors carry out post hoc analysis of multi-center cohorts to investigate the anatomical and functional correlates of effective deep brain stimulation, and find that stimulating circuit of Papez, fornix and bed nucleus of the stria terminalis, and a multi-region functional network, were associated with clinical improvement.
AbstractList Deep brain stimulation (DBS) to the fornix is an investigational treatment for patients with mild Alzheimer's Disease. Outcomes from randomized clinical trials have shown that cognitive function improved in some patients but deteriorated in others. This could be explained by variance in electrode placement leading to differential engagement of neural circuits. To investigate this, we performed a post-hoc analysis on a multi-center cohort of 46 patients with DBS to the fornix (NCT00658125, NCT01608061). Using normative structural and functional connectivity data, we found that stimulation of the circuit of Papez and stria terminalis robustly associated with cognitive improvement (R = 0.53, p < 0.001). On a local level, the optimal stimulation site resided at the direct interface between these structures (R = 0.48, p < 0.001). Finally, modulating specific distributed brain networks related to memory accounted for optimal outcomes (R = 0.48, p < 0.001). Findings were robust to multiple cross-validation designs and may define an optimal network target that could refine DBS surgery and programming.Deep brain stimulation (DBS) to the fornix is an investigational treatment for patients with mild Alzheimer's Disease. Outcomes from randomized clinical trials have shown that cognitive function improved in some patients but deteriorated in others. This could be explained by variance in electrode placement leading to differential engagement of neural circuits. To investigate this, we performed a post-hoc analysis on a multi-center cohort of 46 patients with DBS to the fornix (NCT00658125, NCT01608061). Using normative structural and functional connectivity data, we found that stimulation of the circuit of Papez and stria terminalis robustly associated with cognitive improvement (R = 0.53, p < 0.001). On a local level, the optimal stimulation site resided at the direct interface between these structures (R = 0.48, p < 0.001). Finally, modulating specific distributed brain networks related to memory accounted for optimal outcomes (R = 0.48, p < 0.001). Findings were robust to multiple cross-validation designs and may define an optimal network target that could refine DBS surgery and programming.
Deep brain stimulation (DBS) to the fornix is an investigational treatment for patients with mild Alzheimer’s Disease. Outcomes from randomized clinical trials have shown that cognitive function improved in some patients but deteriorated in others. This could be explained by variance in electrode placement leading to differential engagement of neural circuits. To investigate this, we performed a post-hoc analysis on a multi-center cohort of 46 patients with DBS to the fornix (NCT00658125, NCT01608061). Using normative structural and functional connectivity data, we found that stimulation of the circuit of Papez and stria terminalis robustly associated with cognitive improvement (R = 0.53, p < 0.001). On a local level, the optimal stimulation site resided at the direct interface between these structures (R = 0.48, p < 0.001). Finally, modulating specific distributed brain networks related to memory accounted for optimal outcomes (R = 0.48, p < 0.001). Findings were robust to multiple cross-validation designs and may define an optimal network target that could refine DBS surgery and programming.Deep brain stimulation has been investigated as a potential treatment for cognitive impairments in Alzheimer’s disease. Here the authors carry out post hoc analysis of multi-center cohorts to investigate the anatomical and functional correlates of effective deep brain stimulation, and find that stimulating circuit of Papez, fornix and bed nucleus of the stria terminalis, and a multi-region functional network, were associated with clinical improvement.
Deep brain stimulation has been investigated as a potential treatment for cognitive impairments in Alzheimer’s disease. Here the authors carry out post hoc analysis of multi-center cohorts to investigate the anatomical and functional correlates of effective deep brain stimulation, and find that stimulating circuit of Papez, fornix and bed nucleus of the stria terminalis, and a multi-region functional network, were associated with clinical improvement.
Deep brain stimulation (DBS) to the fornix is an investigational treatment for patients with mild Alzheimer’s Disease. Outcomes from randomized clinical trials have shown that cognitive function improved in some patients but deteriorated in others. This could be explained by variance in electrode placement leading to differential engagement of neural circuits. To investigate this, we performed a post-hoc analysis on a multi-center cohort of 46 patients with DBS to the fornix (NCT00658125, NCT01608061). Using normative structural and functional connectivity data, we found that stimulation of the circuit of Papez and stria terminalis robustly associated with cognitive improvement ( R  = 0.53, p  < 0.001). On a local level, the optimal stimulation site resided at the direct interface between these structures ( R  = 0.48, p  < 0.001). Finally, modulating specific distributed brain networks related to memory accounted for optimal outcomes ( R  = 0.48, p  < 0.001). Findings were robust to multiple cross-validation designs and may define an optimal network target that could refine DBS surgery and programming.
Deep brain stimulation (DBS) to the fornix is an investigational treatment for patients with mild Alzheimer's Disease. Outcomes from randomized clinical trials have shown that cognitive function improved in some patients but deteriorated in others. This could be explained by variance in electrode placement leading to differential engagement of neural circuits. To investigate this, we performed a post-hoc analysis on a multi-center cohort of 46 patients with DBS to the fornix (NCT00658125, NCT01608061). Using normative structural and functional connectivity data, we found that stimulation of the circuit of Papez and stria terminalis robustly associated with cognitive improvement (R = 0.53, p < 0.001). On a local level, the optimal stimulation site resided at the direct interface between these structures (R = 0.48, p < 0.001). Finally, modulating specific distributed brain networks related to memory accounted for optimal outcomes (R = 0.48, p < 0.001). Findings were robust to multiple cross-validation designs and may define an optimal network target that could refine DBS surgery and programming.
Deep brain stimulation (DBS) to the fornix is an investigational treatment for patients with mild Alzheimer’s Disease. Outcomes from randomized clinical trials have shown that cognitive function improved in some patients but deteriorated in others. This could be explained by variance in electrode placement leading to differential engagement of neural circuits. To investigate this, we performed a post-hoc analysis on a multi-center cohort of 46 patients with DBS to the fornix (NCT00658125, NCT01608061). Using normative structural and functional connectivity data, we found that stimulation of the circuit of Papez and stria terminalis robustly associated with cognitive improvement ( R  = 0.53, p  < 0.001). On a local level, the optimal stimulation site resided at the direct interface between these structures ( R  = 0.48, p  < 0.001). Finally, modulating specific distributed brain networks related to memory accounted for optimal outcomes ( R  = 0.48, p  < 0.001). Findings were robust to multiple cross-validation designs and may define an optimal network target that could refine DBS surgery and programming. Deep brain stimulation has been investigated as a potential treatment for cognitive impairments in Alzheimer’s disease. Here the authors carry out post hoc analysis of multi-center cohorts to investigate the anatomical and functional correlates of effective deep brain stimulation, and find that stimulating circuit of Papez, fornix and bed nucleus of the stria terminalis, and a multi-region functional network, were associated with clinical improvement.
ArticleNumber 7707
Author Wolk, David A.
Smith, Gwenn S.
Ríos, Ana Sofía
Mari, Zoltan
Foote, Kelly D.
Rosenberg, Paul B.
Oxenford, Simón
Germann, Jurgen
Amaral, Robert
Almeida, Leonardo Brito de
Chakravarty, M. Mallar
Lyketsos, Constantine G.
Salloway, Stephen
Butenko, Konstantin
Elias, Gavin J. B.
Lozano, Andres M.
Okun, Michael S.
Ponce, Francisco A.
Neudorfer, Clemens
Rajamani, Nanditha
Deeb, Wissam
Wang, Fuyixue
Burke, Anna D.
Horn, Andreas
Salvato, Bryan
Loh, Aaron
Li, Ningfei
Setsompop, Kawin
Tang-Wai, David F.
Anderson, William S.
Sabbagh, Marwan N.
Boutet, Alexandre
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/36517479$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1002/ana.24974
10.1016/j.neuroimage.2015.05.020
10.1016/j.jalz.2011.05.2416
10.1016/j.neuron.2013.01.020
10.1109/TMI.2008.2012113
10.1038/s41467-020-16734-3
10.37765/ajmc.2020.88482
10.1002/ana.21295
10.1016/j.neuroimage.2016.10.027
10.1002/acn3.168
10.1001/jamapsychiatry.2019.3671
10.1152/jn.00338.2011
10.1016/j.tics.2005.12.004
10.1016/j.media.2007.06.004
10.1176/ajp.141.11.1356
10.1002/alz.12238
10.1038/s41597-021-00904-z
10.1016/j.clinph.2004.01.001
10.3389/fnagi.2015.00001
10.3233/JAD-142292
10.1093/brain/awt304
10.1186/s12910-018-0275-4
10.1016/j.neuroimage.2018.08.068
10.1016/j.neuroimage.2014.12.002
10.1016/j.neubiorev.2013.03.009
10.1126/science.1119055
10.4103/sni.sni_342_17
10.1016/j.cell.2019.02.014
10.1016/j.neuropsychologia.2009.01.020
10.1093/brain/awab170
10.1016/j.neubiorev.2017.04.018
10.1016/j.biopsych.2021.04.006
10.1002/(SICI)1096-9861(19970728)384:2<312::AID-CNE10>3.0.CO;2-K
10.3389/fnagi.2014.00241
10.3171/2015.6.JNS15716
10.1002/ana.22089
10.1097/WCO.0000000000000679
10.1097/00002093-199700112-00003
10.1126/science.abb4588
10.1038/nature20412
10.3233/JAD-160017
10.1001/jamaneurol.2015.2564
10.1093/brain/awq203
10.1093/brain/86.4.595
10.1016/j.neuron.2011.11.001
10.1056/NEJMc1905240
10.1016/j.biopsych.2018.12.019
10.1109/TBME.2014.2363494
10.1212/WNL.58.12.1791
10.1371/journal.pone.0176132
10.1016/j.neuroimage.2020.117307
10.1073/pnas.0308627101
10.1016/j.brainres.2013.03.052
10.1038/sdata.2015.31
10.3233/JAD-180121
10.1038/s41597-019-0254-8
10.1001/jamaneurol.2013.3263
10.1038/nature20587
10.1038/s41597-020-00644-6
10.1016/j.jalz.2011.10.007
10.1016/j.nicl.2017.10.004
10.1093/brain/aww083
10.1016/j.neuroimage.2017.02.004
10.1016/j.tics.2010.08.004
10.1007/s12021-011-9108-z
10.1016/j.jalz.2011.03.004
10.1186/s12938-018-0463-y
10.1371/journal.pcbi.1005649
10.1016/j.neuroimage.2008.12.037
10.1007/BF00308809
10.1002/ana.25734
10.1016/j.neuroimage.2020.117018
10.1016/j.brs.2021.03.009
10.1109/TMI.2010.2045126
10.4061/2011/535816
10.1111/ner.13356
10.3233/JAD-171071
10.1016/j.biopsych.2021.07.010
10.1101/2021.08.09.21261792
10.1101/2021.07.28.21261289
ContentType Journal Article
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References Alle, Geiger (CR78) 2006; 311
Fletcher (CR19) 2013; 70
Horn (CR35) 2019; 184
Wang (CR67) 2021; 224
Wang (CR43) 2021; 8
Braak, Braak (CR7) 1991; 82
Mevel, Chételat, Eustache, Desgranges (CR4) 2011; 2011
CR34
Lozano, Lipsman (CR11) 2013; 77
Treu (CR36) 2020; 219
Germann (CR31) 2021; 17
Jeong (CR8) 2004; 115
Bittlinger, Müller (CR28) 2018; 19
Musso (CR58) 2015; 117
Nowrangi, Rosenberg (CR22) 2015; 7
Poldrack (CR57) 2011; 72
Canter, Penney, Tsai (CR5) 2016; 539
Martorell (CR17) 2019; 177
Zalesky, Fornito (CR75) 2009; 28
Hyman (CR2) 2012; 8
Deeb (CR30) 2019; 381
Holmes (CR47) 2015; 2
Yeo (CR48) 2011; 106
Avants, Epstein, Grossman, Gee (CR63) 2008; 12
Gunalan (CR77) 2017; 12
Li (CR14) 2020; 11
Iaccarino (CR16) 2016; 540
Greicius, Srivastava, Reiss, Menon (CR3) 2004; 101
Leoutsakos (CR33) 2018; 64
Poldrack (CR56) 2006; 10
Groppa (CR79) 2014; 137
CR40
Pakkenberg, Gundersen (CR74) 1997; 384
Kitamura (CR10) 2013; 1515
Horn (CR12) 2017; 82
Yarkoni, Poldrack, Van Essen, Wager (CR50) 2010; 14
Amunts, Mohlberg, Bludau, Zilles (CR84) 2020; 369
Jacobs, Radua, Lückmann, Sack (CR9) 2013; 37
Amaral (CR46) 2018; 170
Lozano (CR29) 2016; 54
Poldrack, Huckins, Varoquaux (CR45) 2020; 77
Klein (CR72) 2009; 46
Choi, Riva-Posse, Gross, Mayberg (CR41) 2015; 72
Hamani (CR23) 2008; 63
Mielke (CR20) 2012; 8
Husch, V Petersen, Gemmar, Goncalves, Hertel (CR64) 2018; 17
Piolino, Desgranges, Eustache (CR71) 2009; 47
Edlow (CR83) 2019; 6
Neudorfer (CR32) 2021; 144
CR15
Jack (CR68) 2011; 7
Scharre (CR26) 2018; 62
Noecker (CR59) 2021; 12
Migliaccio (CR60) 2015; 46
Lancaster (CR82) 2011; 9
Villain (CR61) 2010; 133
CR51
Li (CR66) 2021; 90
Baldermann (CR38) 2019; 85
Horn (CR55) 2017; 150
Vorwerk, Oostenveld, Piastra, Magyari, Wolters (CR73) 2018; 17
Howell (CR76) 2021; 14
Reich (CR80) 2015; 2
Rosen, Mohs, Davis (CR70) 1984; 141
Thal, Rüb, Orantes, Braak (CR6) 2002; 58
Rubin (CR49) 2017; 13
Irmen (CR42) 2020; 87
Horn (CR37) 2019; 32
Oishi, Lyketsos (CR21) 2014; 6
Al-Fatly (CR13) 2019; 18
Mohs (CR69) 1997; 11
Neudorfer (CR39) 2020; 7
Ponce (CR53) 2016; 125
Aggleton, Pralus, Nelson, Hornberger (CR54) 2016; 139
Baldermann (CR27) 2017; 26
Wen-Yih Isaac Tseng (CR81) 2010; 29
CR65
Curot (CR52) 2017; 78
Aldehri, Temel, Alnaami, Jahanshahi, Hescham (CR18) 2018; 9
Laxton (CR25) 2010; 68
Penfield, Perot (CR24) 1963; 86
Horn, Kühn (CR62) 2015; 107
Astrom, Diczfalusy, Martens, Wardell (CR44) 2015; 62
Winston (CR1) 2020; 26
A Horn (34510_CR12) 2017; 82
W Penfield (34510_CR24) 1963; 86
RSC Amaral (34510_CR46) 2018; 170
RA Poldrack (34510_CR56) 2006; 10
34510_CR15
M Aldehri (34510_CR18) 2018; 9
D Scharre (34510_CR26) 2018; 62
AM Noecker (34510_CR59) 2021; 12
S Treu (34510_CR36) 2020; 219
MD Greicius (34510_CR3) 2004; 101
AJ Martorell (34510_CR17) 2019; 177
34510_CR51
W Winston (34510_CR1) 2020; 26
B Pakkenberg (34510_CR74) 1997; 384
A Horn (34510_CR37) 2019; 32
KS Choi (34510_CR41) 2015; 72
A Husch (34510_CR64) 2018; 17
K Mevel (34510_CR4) 2011; 2011
F Irmen (34510_CR42) 2020; 87
A Horn (34510_CR62) 2015; 107
AM Lozano (34510_CR11) 2013; 77
RC Mohs (34510_CR69) 1997; 11
J Jeong (34510_CR8) 2004; 115
JC Baldermann (34510_CR38) 2019; 85
HF Iaccarino (34510_CR16) 2016; 540
BT Hyman (34510_CR2) 2012; 8
TN Rubin (34510_CR49) 2017; 13
C Neudorfer (34510_CR32) 2021; 144
R Migliaccio (34510_CR60) 2015; 46
N Li (34510_CR14) 2020; 11
CR Jack (34510_CR68) 2011; 7
JL Lancaster (34510_CR82) 2011; 9
34510_CR40
K Gunalan (34510_CR77) 2017; 12
C Neudorfer (34510_CR39) 2020; 7
M Astrom (34510_CR44) 2015; 62
RG Canter (34510_CR5) 2016; 539
C Hamani (34510_CR23) 2008; 63
A Zalesky (34510_CR75) 2009; 28
T Yarkoni (34510_CR50) 2010; 14
M Musso (34510_CR58) 2015; 117
B Howell (34510_CR76) 2021; 14
AM Lozano (34510_CR29) 2016; 54
MM Mielke (34510_CR20) 2012; 8
S Groppa (34510_CR79) 2014; 137
M Bittlinger (34510_CR28) 2018; 19
DR Thal (34510_CR6) 2002; 58
34510_CR34
JC Baldermann (34510_CR27) 2017; 26
RA Poldrack (34510_CR57) 2011; 72
J Germann (34510_CR31) 2021; 17
HIL Jacobs (34510_CR9) 2013; 37
F Wang (34510_CR43) 2021; 8
JP Aggleton (34510_CR54) 2016; 139
MA Nowrangi (34510_CR22) 2015; 7
N Villain (34510_CR61) 2010; 133
N Li (34510_CR66) 2021; 90
K Amunts (34510_CR84) 2020; 369
K Oishi (34510_CR21) 2014; 6
AW Laxton (34510_CR25) 2010; 68
B Avants (34510_CR63) 2008; 12
RA Poldrack (34510_CR45) 2020; 77
MM Reich (34510_CR80) 2015; 2
J Curot (34510_CR52) 2017; 78
W Deeb (34510_CR30) 2019; 381
Q Wang (34510_CR67) 2021; 224
BTT Yeo (34510_CR48) 2011; 106
34510_CR65
BL Edlow (34510_CR83) 2019; 6
H Alle (34510_CR78) 2006; 311
P Piolino (34510_CR71) 2009; 47
S Kitamura (34510_CR10) 2013; 1515
A Klein (34510_CR72) 2009; 46
FA Ponce (34510_CR53) 2016; 125
WG Rosen (34510_CR70) 1984; 141
H Braak (34510_CR7) 1991; 82
J-MS Leoutsakos (34510_CR33) 2018; 64
E Fletcher (34510_CR19) 2013; 70
J Vorwerk (34510_CR73) 2018; 17
A Horn (34510_CR35) 2019; 184
A Horn (34510_CR55) 2017; 150
AJ Holmes (34510_CR47) 2015; 2
B Al-Fatly (34510_CR13) 2019; 18
F-CY Wen-Yih Isaac Tseng (34510_CR81) 2010; 29
References_xml – volume: 82
  start-page: 67
  year: 2017
  end-page: 78
  ident: CR12
  article-title: Connectivity predicts deep brain stimulation outcome in Parkinson disease
  publication-title: Ann. Neurol.
  doi: 10.1002/ana.24974
– volume: 117
  start-page: 267
  year: 2015
  end-page: 283
  ident: CR58
  article-title: A single dual-stream framework for syntactic computations in music and language
  publication-title: NeuroImage
  doi: 10.1016/j.neuroimage.2015.05.020
– volume: 8
  start-page: 105
  year: 2012
  end-page: 113
  ident: CR20
  article-title: Fornix integrity and hippocampal volume predict memory decline and progression to Alzheimer’s disease
  publication-title: Alzheimer’s Dement.
  doi: 10.1016/j.jalz.2011.05.2416
– volume: 77
  start-page: 406
  year: 2013
  end-page: 424
  ident: CR11
  article-title: Probing and regulating dysfunctional circuits using deep brain stimulation
  publication-title: Neuron
  doi: 10.1016/j.neuron.2013.01.020
– volume: 28
  start-page: 1023
  year: 2009
  end-page: 1036
  ident: CR75
  article-title: A DTI-derived measure of cortico-cortical connectivity
  publication-title: IEEE Trans. Med Imaging
  doi: 10.1109/TMI.2008.2012113
– volume: 11
  year: 2020
  ident: CR14
  article-title: A unified connectomic target for deep brain stimulation in obsessive-compulsive disorder
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-020-16734-3
– volume: 26
  start-page: S177
  year: 2020
  end-page: S183
  ident: CR1
  article-title: Economic burden of Alzheimer disease and managed care considerations
  publication-title: Am. J. Manage. Care
  doi: 10.37765/ajmc.2020.88482
– ident: CR51
– volume: 63
  start-page: 119
  year: 2008
  end-page: 123
  ident: CR23
  article-title: Memory enhancement induced by hypothalamic/fornix deep brain stimulation
  publication-title: Ann. Neurol.
  doi: 10.1002/ana.21295
– volume: 170
  start-page: 132
  year: 2018
  end-page: 150
  ident: CR46
  article-title: Manual segmentation of the fornix, fimbria, and alveus on high-resolution 3T MRI: Application via fully-automated mapping of the human memory circuit white and grey matter in healthy and pathological aging
  publication-title: Neuroimage
  doi: 10.1016/j.neuroimage.2016.10.027
– volume: 2
  start-page: 427
  year: 2015
  end-page: 432
  ident: CR80
  article-title: Short pulse width widens the therapeutic window of subthalamic neurostimulation
  publication-title: Ann. Clin. Transl. Neurol.
  doi: 10.1002/acn3.168
– volume: 77
  start-page: 534
  year: 2020
  end-page: 540
  ident: CR45
  article-title: Establishment of best practices for evidence for prediction: a review
  publication-title: JAMA Psychiatry
  doi: 10.1001/jamapsychiatry.2019.3671
– volume: 106
  start-page: 1125
  year: 2011
  end-page: 1165
  ident: CR48
  article-title: The organization of the human cerebral cortex estimated by intrinsic functional connectivity
  publication-title: J. Neurophysiol.
  doi: 10.1152/jn.00338.2011
– volume: 10
  start-page: 59
  year: 2006
  end-page: 63
  ident: CR56
  article-title: Can cognitive processes be inferred from neuroimaging data?
  publication-title: Trends Cogn. Sci.
  doi: 10.1016/j.tics.2005.12.004
– volume: 12
  start-page: 26
  year: 2008
  end-page: 41
  ident: CR63
  article-title: Symmetric diffeomorphic image registration with cross-correlation: Evaluating automated labeling of elderly and neurodegenerative brain
  publication-title: Med. Image Anal.
  doi: 10.1016/j.media.2007.06.004
– volume: 141
  start-page: 1356
  year: 1984
  end-page: 1364
  ident: CR70
  article-title: A new rating scale for Alzheimer’s disease
  publication-title: Am. J. Psychiatry
  doi: 10.1176/ajp.141.11.1356
– volume: 17
  start-page: 777
  year: 2021
  end-page: 787
  ident: CR31
  article-title: Brain structures and networks responsible for stimulation‐induced memory flashbacks during forniceal deep brain stimulation for Alzheimer’s disease
  publication-title: Alzheimer’s Dement.
  doi: 10.1002/alz.12238
– volume: 8
  year: 2021
  ident: CR43
  article-title: In vivo human whole-brain Connectom diffusion MRI dataset at 760 µm isotropic resolution
  publication-title: Sci. Data
  doi: 10.1038/s41597-021-00904-z
– volume: 115
  start-page: 1490
  year: 2004
  end-page: 1505
  ident: CR8
  article-title: EEG dynamics in patients with Alzheimer’s disease
  publication-title: Clin. Neurophysiol.
  doi: 10.1016/j.clinph.2004.01.001
– volume: 7
  start-page: 1
  year: 2015
  ident: CR22
  article-title: The fornix in mild cognitive impairment and Alzheimer’s disease
  publication-title: Front. Aging Neurosci.
  doi: 10.3389/fnagi.2015.00001
– volume: 46
  start-page: 351
  year: 2015
  end-page: 364
  ident: CR60
  article-title: Mapping the progression of atrophy in early- and late-onset Alzheimer’s disease
  publication-title: J. Alzheimers Dis.
  doi: 10.3233/JAD-142292
– volume: 137
  start-page: 109
  year: 2014
  end-page: 121
  ident: CR79
  article-title: Physiological and anatomical decomposition of subthalamic neurostimulation effects in essential tremor
  publication-title: Brain
  doi: 10.1093/brain/awt304
– volume: 19
  start-page: 41
  year: 2018
  ident: CR28
  article-title: Opening the debate on deep brain stimulation for ALzheimer’s disease - a critical evaluation of rationale, shortcomings, and ethical justification
  publication-title: BMC Med Ethics
  doi: 10.1186/s12910-018-0275-4
– volume: 184
  start-page: 293
  year: 2019
  end-page: 316
  ident: CR35
  article-title: Lead-DBS v2: Towards a comprehensive pipeline for deep brain stimulation imaging
  publication-title: NeuroImage
  doi: 10.1016/j.neuroimage.2018.08.068
– volume: 107
  start-page: 127
  year: 2015
  end-page: 135
  ident: CR62
  article-title: Lead-DBS: A toolbox for deep brain stimulation electrode localizations and visualizations
  publication-title: NeuroImage
  doi: 10.1016/j.neuroimage.2014.12.002
– volume: 37
  start-page: 753
  year: 2013
  end-page: 765
  ident: CR9
  article-title: Meta-analysis of functional network alterations in Alzheimer’s disease: toward a network biomarker
  publication-title: Neurosci. Biobehav. Rev.
  doi: 10.1016/j.neubiorev.2013.03.009
– volume: 311
  start-page: 1290
  year: 2006
  end-page: 1293
  ident: CR78
  article-title: Combined analog and action potential coding in hippocampal mossy fibers
  publication-title: Science
  doi: 10.1126/science.1119055
– volume: 9
  start-page: 58
  year: 2018
  ident: CR18
  article-title: Deep brain stimulation for Alzheimer’s Disease: An update
  publication-title: Surg. Neurol. Int
  doi: 10.4103/sni.sni_342_17
– volume: 2011
  start-page: 535816
  year: 2011
  ident: CR4
  article-title: The default mode network in healthy aging and Alzheimer’s disease
  publication-title: Int J. Alzheimers Dis.
– ident: CR15
– volume: 177
  start-page: 256
  year: 2019
  end-page: 271.e22
  ident: CR17
  article-title: Multi-sensory Gamma stimulation ameliorates Alzheimer’s-associated pathology and improves cognition
  publication-title: Cell
  doi: 10.1016/j.cell.2019.02.014
– volume: 12
  start-page: 75
  year: 2021
  end-page: 11
  ident: CR59
  article-title: StimVisionv2: Examples and applications in subthalamic deep brain stimulation for Parkinson’s disease
  publication-title: Neuromodulation: Technol. Neural Interface
– volume: 47
  start-page: 2314
  year: 2009
  end-page: 2329
  ident: CR71
  article-title: Episodic autobiographical memories over the course of time: Cognitive, neuropsychological and neuroimaging findings
  publication-title: Neuropsychologia
  doi: 10.1016/j.neuropsychologia.2009.01.020
– volume: 18
  start-page: 130
  year: 2019
  ident: CR13
  article-title: Connectivity profile of thalamic deep brain stimulation to effectively treat essential tremor
  publication-title: Brain
– volume: 62
  start-page: 1
  year: 2018
  end-page: 13
  ident: CR26
  article-title: Deep brain stimulation of frontal lobe networks to treat Alzheimer’s disease
  publication-title: J. Alzheimer’s Dis.
– volume: 144
  start-page: 2837
  year: 2021
  end-page: 2851
  ident: CR32
  article-title: Mapping autonomic, mood and cognitive effects of hypothalamic region deep brain stimulation | Brain | Oxford Academic
  publication-title: Brain
  doi: 10.1093/brain/awab170
– volume: 78
  start-page: 161
  year: 2017
  end-page: 177
  ident: CR52
  article-title: Memory scrutinized through electrical brain stimulation: A review of 80 years of experiential phenomena
  publication-title: Neurosci. Biobehav. Rev.
  doi: 10.1016/j.neubiorev.2017.04.018
– volume: 90
  start-page: 701
  year: 2021
  end-page: 713
  ident: CR66
  article-title: A Unified functional network target for deep brain stimulation in obsessive-compulsive disorder
  publication-title: Biol. Psychiatry
  doi: 10.1016/j.biopsych.2021.04.006
– volume: 384
  start-page: 312
  year: 1997
  end-page: 320
  ident: CR74
  article-title: Neocortical neuron number in humans: effect of sex and age
  publication-title: J. Comp. Neurol.
  doi: 10.1002/(SICI)1096-9861(19970728)384:2<312::AID-CNE10>3.0.CO;2-K
– volume: 6
  start-page: 241
  year: 2014
  ident: CR21
  article-title: Alzheimer’s disease and the fornix
  publication-title: Front. Aging Neurosci.
  doi: 10.3389/fnagi.2014.00241
– volume: 125
  start-page: 75
  year: 2016
  end-page: 84
  ident: CR53
  article-title: Bilateral deep brain stimulation of the fornix for Alzheimer’s disease: surgical safety in the ADvance trial
  publication-title: J. Neurosurg.
  doi: 10.3171/2015.6.JNS15716
– volume: 68
  start-page: 521
  year: 2010
  end-page: 534
  ident: CR25
  article-title: A phase I trial of deep brain stimulation of memory circuits in Alzheimer’s disease
  publication-title: Ann. Neurol.
  doi: 10.1002/ana.22089
– volume: 32
  start-page: 511
  year: 2019
  end-page: 520
  ident: CR37
  article-title: The impact of modern-day neuroimaging on the field of deep brain stimulation
  publication-title: Curr. Opin. Neurol.
  doi: 10.1097/WCO.0000000000000679
– volume: 11
  start-page: S13
  year: 1997
  end-page: S21
  ident: CR69
  article-title: Development of cognitive instruments for use in clinical trials of antidementia drugs: additions to the Alzheimer’s disease assessment scale that broaden its scope
  publication-title: Alzheimer Dis. Assoc. Disord.
  doi: 10.1097/00002093-199700112-00003
– volume: 369
  start-page: 988
  year: 2020
  end-page: 992
  ident: CR84
  article-title: Julich-Brain: A 3D probabilistic atlas of the human brain’s cytoarchitecture
  publication-title: Science
  doi: 10.1126/science.abb4588
– volume: 539
  start-page: 187
  year: 2016
  end-page: 196
  ident: CR5
  article-title: The road to restoring neural circuits for the treatment of Alzheimer’s disease
  publication-title: Nature
  doi: 10.1038/nature20412
– volume: 54
  start-page: 777
  year: 2016
  end-page: 787
  ident: CR29
  article-title: A Phase II study of fornix deep brain stimulation in mild Alzheimer’s disease. - PubMed - NCBI
  publication-title: J Alzheimer’s Dis
  doi: 10.3233/JAD-160017
– volume: 72
  start-page: 1252
  year: 2015
  end-page: 1260
  ident: CR41
  article-title: Mapping the “Depression Switch” during intraoperative testing of subcallosal cingulate deep brain stimulation
  publication-title: JAMA Neurol.
  doi: 10.1001/jamaneurol.2015.2564
– volume: 133
  start-page: 3301
  year: 2010
  end-page: 3314
  ident: CR61
  article-title: Sequential relationships between grey matter and white matter atrophy and brain metabolic abnormalities in early Alzheimer’s disease
  publication-title: Brain
  doi: 10.1093/brain/awq203
– volume: 86
  start-page: 595
  year: 1963
  end-page: 696
  ident: CR24
  article-title: The brain’s record of auditory and visual experience: a final summary and discussion
  publication-title: Brain
  doi: 10.1093/brain/86.4.595
– volume: 72
  start-page: 692
  year: 2011
  end-page: 697
  ident: CR57
  article-title: Inferring mental states from neuroimaging data: from reverse inference to large-scale decoding
  publication-title: Neuron
  doi: 10.1016/j.neuron.2011.11.001
– volume: 381
  start-page: 783
  year: 2019
  end-page: 785
  ident: CR30
  article-title: Fornix-region deep brain stimulation–induced memory flashbacks in Alzheimer’s disease
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMc1905240
– volume: 85
  start-page: 735
  year: 2019
  end-page: 743
  ident: CR38
  article-title: Connectivity profile predictive of effective deep brain stimulation in obsessive-compulsive disorder
  publication-title: Biol. Psychiatry
  doi: 10.1016/j.biopsych.2018.12.019
– volume: 26
  start-page: 2411
  year: 2017
  ident: CR27
  article-title: Neuroanatomical characteristics associated with response to deep brain stimulation of the nucleus Basalis of Meynert for Alzheimer’s disease
  publication-title: Neuromodulation: Technol. Neural Interface
– volume: 62
  start-page: 664
  year: 2015
  end-page: 672
  ident: CR44
  article-title: Relationship between neural activation and electric field distribution during deep brain stimulation
  publication-title: IEEE Trans. Biomed. Eng.
  doi: 10.1109/TBME.2014.2363494
– volume: 58
  start-page: 1791
  year: 2002
  end-page: 1800
  ident: CR6
  article-title: Phases of A beta-deposition in the human brain and its relevance for the development of AD
  publication-title: Neurology
  doi: 10.1212/WNL.58.12.1791
– volume: 12
  start-page: e0176132
  year: 2017
  ident: CR77
  article-title: Creating and parameterizing patient-specific deep brain stimulation pathway-activation models using the hyperdirect pathway as an example
  publication-title: PloS one
  doi: 10.1371/journal.pone.0176132
– volume: 224
  start-page: 117307
  year: 2021
  ident: CR67
  article-title: Normative vs. patient-specific brain connectivity in Deep Brain Stimulation
  publication-title: NeuroImage
  doi: 10.1016/j.neuroimage.2020.117307
– volume: 101
  start-page: 4637
  year: 2004
  end-page: 4642
  ident: CR3
  article-title: Default-mode network activity distinguishes Alzheimer’s disease from healthy aging: Evidence from functional MRI
  publication-title: Proc. Natl Acad. Sci.
  doi: 10.1073/pnas.0308627101
– volume: 1515
  start-page: 12
  year: 2013
  end-page: 18
  ident: CR10
  article-title: Longitudinal white matter changes in Alzheimer’s disease: A tractography-based analysis study
  publication-title: Brain Res.
  doi: 10.1016/j.brainres.2013.03.052
– ident: CR40
– volume: 2
  start-page: 1
  year: 2015
  end-page: 16
  ident: CR47
  article-title: Brain Genomics Superstruct Project initial data release with structural, functional, and behavioral measures
  publication-title: Sci. Data
  doi: 10.1038/sdata.2015.31
– volume: 64
  start-page: 597
  year: 2018
  end-page: 606
  ident: CR33
  article-title: Deep brain stimulation targeting the fornix for mild Alzheimer Dementia (the ADvance Trial): A two year follow-up including results of delayed activation
  publication-title: J. Alzheimer’s Dis.
  doi: 10.3233/JAD-180121
– volume: 6
  year: 2019
  ident: CR83
  article-title: 7 Tesla MRI of the ex vivo human brain at 100 micron resolution
  publication-title: Sci. Data
  doi: 10.1038/s41597-019-0254-8
– volume: 70
  start-page: 1389
  year: 2013
  end-page: 1395
  ident: CR19
  article-title: Loss of Fornix white matter volume as a predictor of cognitive impairment in cognitively normal elderly individuals
  publication-title: JAMA Neurol.
  doi: 10.1001/jamaneurol.2013.3263
– volume: 540
  start-page: 230
  year: 2016
  end-page: 235
  ident: CR16
  article-title: Gamma frequency entrainment attenuates amyloid load and modifies microglia
  publication-title: Nature
  doi: 10.1038/nature20587
– volume: 7
  year: 2020
  ident: CR39
  article-title: A high-resolution in vivo magnetic resonance imaging atlas of the human hypothalamic region
  publication-title: Sci. Data
  doi: 10.1038/s41597-020-00644-6
– volume: 8
  start-page: 1
  year: 2012
  end-page: 13
  ident: CR2
  article-title: National Institute on Aging-Alzheimer’s Association guidelines for the neuropathologic assessment of Alzheimer’s disease
  publication-title: Alzheimers Dement
  doi: 10.1016/j.jalz.2011.10.007
– ident: CR65
– volume: 17
  start-page: 80
  year: 2018
  end-page: 89
  ident: CR64
  article-title: PaCER - A fully automated method for electrode trajectory and contact reconstruction in deep brain stimulation
  publication-title: Neuroimage Clin.
  doi: 10.1016/j.nicl.2017.10.004
– volume: 139
  start-page: 1877
  year: 2016
  end-page: 1890
  ident: CR54
  article-title: Thalamic pathology and memory loss in early Alzheimer’s disease: moving the focus from the medial temporal lobe to Papez circuit
  publication-title: Brain
  doi: 10.1093/brain/aww083
– volume: 150
  start-page: 395
  year: 2017
  end-page: 404
  ident: CR55
  article-title: Probabilistic conversion of neurosurgical DBS electrode coordinates into MNI space
  publication-title: NeuroImage
  doi: 10.1016/j.neuroimage.2017.02.004
– volume: 14
  start-page: 489
  year: 2010
  end-page: 496
  ident: CR50
  article-title: Cognitive neuroscience 2.0: building a cumulative science of human brain function
  publication-title: Trends Cogn. Sci.
  doi: 10.1016/j.tics.2010.08.004
– volume: 9
  start-page: 371
  year: 2011
  end-page: 380
  ident: CR82
  article-title: Automated analysis of fundamental features of brain structures
  publication-title: Neuroinform
  doi: 10.1007/s12021-011-9108-z
– volume: 7
  start-page: 257
  year: 2011
  end-page: 262
  ident: CR68
  article-title: Introduction to the recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease
  publication-title: Alzheimers Dement
  doi: 10.1016/j.jalz.2011.03.004
– volume: 17
  year: 2018
  ident: CR73
  article-title: The FieldTrip-SimBio pipeline for EEG forward solutions
  publication-title: Biomed. Eng. Online
  doi: 10.1186/s12938-018-0463-y
– ident: CR34
– volume: 13
  start-page: e1005649
  year: 2017
  ident: CR49
  article-title: Decoding brain activity using a large-scale probabilistic functional-anatomical atlas of human cognition
  publication-title: PLOS Comput. Biol.
  doi: 10.1371/journal.pcbi.1005649
– volume: 46
  start-page: 786
  year: 2009
  end-page: 802
  ident: CR72
  article-title: Evaluation of 14 nonlinear deformation algorithms applied to human brain MRI registration
  publication-title: NeuroImage
  doi: 10.1016/j.neuroimage.2008.12.037
– volume: 82
  start-page: 239
  year: 1991
  end-page: 259
  ident: CR7
  article-title: Neuropathological stageing of Alzheimer-related changes
  publication-title: Acta Neuropathol.
  doi: 10.1007/BF00308809
– volume: 87
  start-page: 962
  year: 2020
  end-page: 975
  ident: CR42
  article-title: Left prefrontal impact links subthalamic stimulation with depressive symptoms
  publication-title: Ann. Neurol.
  doi: 10.1002/ana.25734
– volume: 219
  start-page: 117018
  year: 2020
  ident: CR36
  article-title: Deep brain stimulation: Imaging on a group level
  publication-title: NeuroImage
  doi: 10.1016/j.neuroimage.2020.117018
– volume: 14
  start-page: 549
  year: 2021
  end-page: 563
  ident: CR76
  article-title: Image-based biophysical modeling predicts cortical potentials evoked with subthalamic deep brain stimulation
  publication-title: Brain Stimulation
  doi: 10.1016/j.brs.2021.03.009
– volume: 29
  start-page: 1626
  year: 2010
  end-page: 1635
  ident: CR81
  article-title: Generalized q-Sampling Imaging
  publication-title: IEEE Trans Med Imaging
  doi: 10.1109/TMI.2010.2045126
– volume: 26
  start-page: S177
  year: 2020
  ident: 34510_CR1
  publication-title: Am. J. Manage. Care
  doi: 10.37765/ajmc.2020.88482
– volume: 47
  start-page: 2314
  year: 2009
  ident: 34510_CR71
  publication-title: Neuropsychologia
  doi: 10.1016/j.neuropsychologia.2009.01.020
– volume: 37
  start-page: 753
  year: 2013
  ident: 34510_CR9
  publication-title: Neurosci. Biobehav. Rev.
  doi: 10.1016/j.neubiorev.2013.03.009
– volume: 77
  start-page: 406
  year: 2013
  ident: 34510_CR11
  publication-title: Neuron
  doi: 10.1016/j.neuron.2013.01.020
– volume: 90
  start-page: 701
  year: 2021
  ident: 34510_CR66
  publication-title: Biol. Psychiatry
  doi: 10.1016/j.biopsych.2021.04.006
– volume: 29
  start-page: 1626
  year: 2010
  ident: 34510_CR81
  publication-title: IEEE Trans Med Imaging
  doi: 10.1109/TMI.2010.2045126
– volume: 2011
  start-page: 535816
  year: 2011
  ident: 34510_CR4
  publication-title: Int J. Alzheimers Dis.
  doi: 10.4061/2011/535816
– volume: 101
  start-page: 4637
  year: 2004
  ident: 34510_CR3
  publication-title: Proc. Natl Acad. Sci.
  doi: 10.1073/pnas.0308627101
– volume: 539
  start-page: 187
  year: 2016
  ident: 34510_CR5
  publication-title: Nature
  doi: 10.1038/nature20412
– volume: 14
  start-page: 549
  year: 2021
  ident: 34510_CR76
  publication-title: Brain Stimulation
  doi: 10.1016/j.brs.2021.03.009
– volume: 177
  start-page: 256
  year: 2019
  ident: 34510_CR17
  publication-title: Cell
  doi: 10.1016/j.cell.2019.02.014
– volume: 219
  start-page: 117018
  year: 2020
  ident: 34510_CR36
  publication-title: NeuroImage
  doi: 10.1016/j.neuroimage.2020.117018
– volume: 58
  start-page: 1791
  year: 2002
  ident: 34510_CR6
  publication-title: Neurology
  doi: 10.1212/WNL.58.12.1791
– volume: 63
  start-page: 119
  year: 2008
  ident: 34510_CR23
  publication-title: Ann. Neurol.
  doi: 10.1002/ana.21295
– volume: 13
  start-page: e1005649
  year: 2017
  ident: 34510_CR49
  publication-title: PLOS Comput. Biol.
  doi: 10.1371/journal.pcbi.1005649
– volume: 2
  start-page: 1
  year: 2015
  ident: 34510_CR47
  publication-title: Sci. Data
  doi: 10.1038/sdata.2015.31
– ident: 34510_CR51
– volume: 137
  start-page: 109
  year: 2014
  ident: 34510_CR79
  publication-title: Brain
  doi: 10.1093/brain/awt304
– volume: 125
  start-page: 75
  year: 2016
  ident: 34510_CR53
  publication-title: J. Neurosurg.
  doi: 10.3171/2015.6.JNS15716
– volume: 17
  start-page: 777
  year: 2021
  ident: 34510_CR31
  publication-title: Alzheimer’s Dement.
  doi: 10.1002/alz.12238
– volume: 64
  start-page: 597
  year: 2018
  ident: 34510_CR33
  publication-title: J. Alzheimer’s Dis.
  doi: 10.3233/JAD-180121
– volume: 139
  start-page: 1877
  year: 2016
  ident: 34510_CR54
  publication-title: Brain
  doi: 10.1093/brain/aww083
– volume: 141
  start-page: 1356
  year: 1984
  ident: 34510_CR70
  publication-title: Am. J. Psychiatry
  doi: 10.1176/ajp.141.11.1356
– volume: 62
  start-page: 664
  year: 2015
  ident: 34510_CR44
  publication-title: IEEE Trans. Biomed. Eng.
  doi: 10.1109/TBME.2014.2363494
– volume: 87
  start-page: 962
  year: 2020
  ident: 34510_CR42
  publication-title: Ann. Neurol.
  doi: 10.1002/ana.25734
– volume: 82
  start-page: 67
  year: 2017
  ident: 34510_CR12
  publication-title: Ann. Neurol.
  doi: 10.1002/ana.24974
– volume: 1515
  start-page: 12
  year: 2013
  ident: 34510_CR10
  publication-title: Brain Res.
  doi: 10.1016/j.brainres.2013.03.052
– volume: 86
  start-page: 595
  year: 1963
  ident: 34510_CR24
  publication-title: Brain
  doi: 10.1093/brain/86.4.595
– volume: 46
  start-page: 351
  year: 2015
  ident: 34510_CR60
  publication-title: J. Alzheimers Dis.
  doi: 10.3233/JAD-142292
– volume: 6
  year: 2019
  ident: 34510_CR83
  publication-title: Sci. Data
  doi: 10.1038/s41597-019-0254-8
– ident: 34510_CR40
  doi: 10.1111/ner.13356
– volume: 7
  start-page: 257
  year: 2011
  ident: 34510_CR68
  publication-title: Alzheimers Dement
  doi: 10.1016/j.jalz.2011.03.004
– volume: 107
  start-page: 127
  year: 2015
  ident: 34510_CR62
  publication-title: NeuroImage
  doi: 10.1016/j.neuroimage.2014.12.002
– volume: 12
  start-page: 75
  year: 2021
  ident: 34510_CR59
  publication-title: Neuromodulation: Technol. Neural Interface
– volume: 70
  start-page: 1389
  year: 2013
  ident: 34510_CR19
  publication-title: JAMA Neurol.
  doi: 10.1001/jamaneurol.2013.3263
– volume: 62
  start-page: 1
  year: 2018
  ident: 34510_CR26
  publication-title: J. Alzheimer’s Dis.
  doi: 10.3233/JAD-171071
– volume: 311
  start-page: 1290
  year: 2006
  ident: 34510_CR78
  publication-title: Science
  doi: 10.1126/science.1119055
– volume: 381
  start-page: 783
  year: 2019
  ident: 34510_CR30
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMc1905240
– volume: 68
  start-page: 521
  year: 2010
  ident: 34510_CR25
  publication-title: Ann. Neurol.
  doi: 10.1002/ana.22089
– volume: 9
  start-page: 371
  year: 2011
  ident: 34510_CR82
  publication-title: Neuroinform
  doi: 10.1007/s12021-011-9108-z
– volume: 28
  start-page: 1023
  year: 2009
  ident: 34510_CR75
  publication-title: IEEE Trans. Med Imaging
  doi: 10.1109/TMI.2008.2012113
– volume: 133
  start-page: 3301
  year: 2010
  ident: 34510_CR61
  publication-title: Brain
  doi: 10.1093/brain/awq203
– volume: 7
  start-page: 1
  year: 2015
  ident: 34510_CR22
  publication-title: Front. Aging Neurosci.
  doi: 10.3389/fnagi.2015.00001
– volume: 224
  start-page: 117307
  year: 2021
  ident: 34510_CR67
  publication-title: NeuroImage
  doi: 10.1016/j.neuroimage.2020.117307
– volume: 14
  start-page: 489
  year: 2010
  ident: 34510_CR50
  publication-title: Trends Cogn. Sci.
  doi: 10.1016/j.tics.2010.08.004
– volume: 184
  start-page: 293
  year: 2019
  ident: 34510_CR35
  publication-title: NeuroImage
  doi: 10.1016/j.neuroimage.2018.08.068
– volume: 369
  start-page: 988
  year: 2020
  ident: 34510_CR84
  publication-title: Science
  doi: 10.1126/science.abb4588
– volume: 115
  start-page: 1490
  year: 2004
  ident: 34510_CR8
  publication-title: Clin. Neurophysiol.
  doi: 10.1016/j.clinph.2004.01.001
– volume: 32
  start-page: 511
  year: 2019
  ident: 34510_CR37
  publication-title: Curr. Opin. Neurol.
  doi: 10.1097/WCO.0000000000000679
– volume: 17
  year: 2018
  ident: 34510_CR73
  publication-title: Biomed. Eng. Online
  doi: 10.1186/s12938-018-0463-y
– volume: 78
  start-page: 161
  year: 2017
  ident: 34510_CR52
  publication-title: Neurosci. Biobehav. Rev.
  doi: 10.1016/j.neubiorev.2017.04.018
– volume: 11
  year: 2020
  ident: 34510_CR14
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-020-16734-3
– volume: 19
  start-page: 41
  year: 2018
  ident: 34510_CR28
  publication-title: BMC Med Ethics
  doi: 10.1186/s12910-018-0275-4
– ident: 34510_CR34
  doi: 10.1016/j.biopsych.2021.07.010
– volume: 72
  start-page: 1252
  year: 2015
  ident: 34510_CR41
  publication-title: JAMA Neurol.
  doi: 10.1001/jamaneurol.2015.2564
– volume: 8
  year: 2021
  ident: 34510_CR43
  publication-title: Sci. Data
  doi: 10.1038/s41597-021-00904-z
– volume: 77
  start-page: 534
  year: 2020
  ident: 34510_CR45
  publication-title: JAMA Psychiatry
  doi: 10.1001/jamapsychiatry.2019.3671
– ident: 34510_CR65
  doi: 10.1101/2021.08.09.21261792
– volume: 12
  start-page: 26
  year: 2008
  ident: 34510_CR63
  publication-title: Med. Image Anal.
  doi: 10.1016/j.media.2007.06.004
– volume: 11
  start-page: S13
  year: 1997
  ident: 34510_CR69
  publication-title: Alzheimer Dis. Assoc. Disord.
  doi: 10.1097/00002093-199700112-00003
– volume: 106
  start-page: 1125
  year: 2011
  ident: 34510_CR48
  publication-title: J. Neurophysiol.
  doi: 10.1152/jn.00338.2011
– volume: 46
  start-page: 786
  year: 2009
  ident: 34510_CR72
  publication-title: NeuroImage
  doi: 10.1016/j.neuroimage.2008.12.037
– volume: 26
  start-page: 2411
  year: 2017
  ident: 34510_CR27
  publication-title: Neuromodulation: Technol. Neural Interface
– volume: 150
  start-page: 395
  year: 2017
  ident: 34510_CR55
  publication-title: NeuroImage
  doi: 10.1016/j.neuroimage.2017.02.004
– volume: 8
  start-page: 1
  year: 2012
  ident: 34510_CR2
  publication-title: Alzheimers Dement
  doi: 10.1016/j.jalz.2011.10.007
– volume: 17
  start-page: 80
  year: 2018
  ident: 34510_CR64
  publication-title: Neuroimage Clin.
  doi: 10.1016/j.nicl.2017.10.004
– volume: 384
  start-page: 312
  year: 1997
  ident: 34510_CR74
  publication-title: J. Comp. Neurol.
  doi: 10.1002/(SICI)1096-9861(19970728)384:2<312::AID-CNE10>3.0.CO;2-K
– volume: 9
  start-page: 58
  year: 2018
  ident: 34510_CR18
  publication-title: Surg. Neurol. Int
  doi: 10.4103/sni.sni_342_17
– volume: 72
  start-page: 692
  year: 2011
  ident: 34510_CR57
  publication-title: Neuron
  doi: 10.1016/j.neuron.2011.11.001
– volume: 8
  start-page: 105
  year: 2012
  ident: 34510_CR20
  publication-title: Alzheimer’s Dement.
  doi: 10.1016/j.jalz.2011.05.2416
– volume: 10
  start-page: 59
  year: 2006
  ident: 34510_CR56
  publication-title: Trends Cogn. Sci.
  doi: 10.1016/j.tics.2005.12.004
– volume: 117
  start-page: 267
  year: 2015
  ident: 34510_CR58
  publication-title: NeuroImage
  doi: 10.1016/j.neuroimage.2015.05.020
– volume: 6
  start-page: 241
  year: 2014
  ident: 34510_CR21
  publication-title: Front. Aging Neurosci.
  doi: 10.3389/fnagi.2014.00241
– volume: 144
  start-page: 2837
  year: 2021
  ident: 34510_CR32
  publication-title: Brain
  doi: 10.1093/brain/awab170
– volume: 18
  start-page: 130
  year: 2019
  ident: 34510_CR13
  publication-title: Brain
– volume: 2
  start-page: 427
  year: 2015
  ident: 34510_CR80
  publication-title: Ann. Clin. Transl. Neurol.
  doi: 10.1002/acn3.168
– volume: 54
  start-page: 777
  year: 2016
  ident: 34510_CR29
  publication-title: J Alzheimer’s Dis
  doi: 10.3233/JAD-160017
– volume: 170
  start-page: 132
  year: 2018
  ident: 34510_CR46
  publication-title: Neuroimage
  doi: 10.1016/j.neuroimage.2016.10.027
– volume: 12
  start-page: e0176132
  year: 2017
  ident: 34510_CR77
  publication-title: PloS one
  doi: 10.1371/journal.pone.0176132
– volume: 540
  start-page: 230
  year: 2016
  ident: 34510_CR16
  publication-title: Nature
  doi: 10.1038/nature20587
– ident: 34510_CR15
  doi: 10.1101/2021.07.28.21261289
– volume: 7
  year: 2020
  ident: 34510_CR39
  publication-title: Sci. Data
  doi: 10.1038/s41597-020-00644-6
– volume: 82
  start-page: 239
  year: 1991
  ident: 34510_CR7
  publication-title: Acta Neuropathol.
  doi: 10.1007/BF00308809
– volume: 85
  start-page: 735
  year: 2019
  ident: 34510_CR38
  publication-title: Biol. Psychiatry
  doi: 10.1016/j.biopsych.2018.12.019
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Snippet Deep brain stimulation (DBS) to the fornix is an investigational treatment for patients with mild Alzheimer’s Disease. Outcomes from randomized clinical trials...
Deep brain stimulation (DBS) to the fornix is an investigational treatment for patients with mild Alzheimer's Disease. Outcomes from randomized clinical trials...
Deep brain stimulation has been investigated as a potential treatment for cognitive impairments in Alzheimer’s disease. Here the authors carry out post hoc...
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StartPage 7707
SubjectTerms 59
59/36
59/57
692/308/575
692/699/375/132/1283
Alzheimer Disease - therapy
Alzheimer's disease
Brain
Brain - diagnostic imaging
Circuits
Clinical trials
Cognitive ability
Deep Brain Stimulation
Fornix
Fornix, Brain - diagnostic imaging
Fornix, Brain - physiology
Health services
Humanities and Social Sciences
Humans
multidisciplinary
Neural networks
Neurodegenerative diseases
Patients
Randomized Controlled Trials as Topic
Science
Science (multidisciplinary)
Stimulation
Stria terminalis
Structure-function relationships
Thalamus
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Title Optimal deep brain stimulation sites and networks for stimulation of the fornix in Alzheimer’s disease
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