Dairy intake during adolescence and risk of colorectal adenoma later in life

Background Higher dairy intake during adulthood has been associated with lower colorectal cancer risk. As colorectal carcinogenesis spans several decades, we hypothesised that higher dairy intake during adolescence is associated with lower risk of colorectal adenoma, a colorectal cancer precursor. M...

Full description

Saved in:
Bibliographic Details
Published in:British journal of cancer Vol. 124; no. 6; pp. 1160 - 1168
Main Authors: Nimptsch, Katharina, Lee, Dong Hoon, Zhang, Xuehong, Song, Mingyang, Farvid, Maryam S., Rezende, Leandro F. M., Cao, Yin, Chan, Andrew T., Fuchs, Charles, Meyerhardt, Jeffrey, Nowak, Jonathan A., Willett, Walter C., Ogino, Shuji, Giovannucci, Edward, Pischon, Tobias, Wu, Kana
Format: Journal Article
Language:English
Published: London Nature Publishing Group UK 16.03.2021
Nature Publishing Group
Subjects:
692/699/67/1504/1885
692/699/67/2324
Adenoma
Adenoma - diet therapy
Adenoma - epidemiology
Adolescence
Adolescent
Adolescents
Adult
Biomedical and Life Sciences
Biomedicine
Cancer Research
Carcinogenesis
Child development
Colorectal cancer
Colorectal carcinoma
Colorectal Neoplasms - diet therapy
Colorectal Neoplasms - epidemiology
Dairy Products - statistics & numerical data
Diet
Drug Resistance
Endoscopy
Epidemiology
Feeding Behavior
Female
Follow-Up Studies
Humans
Intestine
Molecular Medicine
Oncology
Prognosis
Prospective Studies
Rectum
Risk Factors
Surveys and Questionnaires
Teenagers
Tumors
United States - epidemiology
United States
ISSN:0007-0920, 1532-1827, 1532-1827
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background Higher dairy intake during adulthood has been associated with lower colorectal cancer risk. As colorectal carcinogenesis spans several decades, we hypothesised that higher dairy intake during adolescence is associated with lower risk of colorectal adenoma, a colorectal cancer precursor. Methods In 27,196 females from the Nurses’ Health Study 2, aged 25–42 years at recruitment (1989), who had completed a validated high school diet questionnaire in 1998 and undergone at least one lower bowel endoscopy between 1998 and 2011, logistic regression for clustered data was used to calculate odds ratios (ORs) and 95% confidence intervals (CI). Results Colorectal adenomas were diagnosed in 2239 women. Dairy consumption during adolescence was not associated with colorectal adenoma risk (OR highest vs. lowest [≥4 vs. ≤1.42 servings/day] quintile [95% CI] 0.94 [0.80, 1.11]). By anatomical site, higher adolescent dairy intake was associated with lower rectal (0.63 [0.42, 0.95]), but not proximal (1.01 [0.80, 1.28]) or distal (0.97 [0.76, 1.24]) colon adenoma risk. An inverse association was observed with histologically advanced (0.72 [0.51, 1.00]) but not non-advanced (1.07 [0.86, 1.33]) adenoma. Conclusions In this large cohort of younger women, higher adolescent dairy intake was associated with lower rectal and advanced adenoma risk later in life.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
ISSN:0007-0920
1532-1827
1532-1827
DOI:10.1038/s41416-020-01203-x