RPA shields inherited DNA lesions for post-mitotic DNA synthesis

The paradigm that checkpoints halt cell cycle progression for genome repair has been challenged by the recent discovery of heritable DNA lesions escaping checkpoint control. How such inherited lesions affect genome function and integrity is not well understood. Here, we identify a new class of herit...

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Bibliographic Details
Published in:	Nature communications Vol. 12; no. 1; pp. 3827 - 15
Main Authors:	Lezaja, Aleksandra, Panagopoulos, Andreas, Wen, Yanlin, Carvalho, Edison, Imhof, Ralph, Altmeyer, Matthias
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 22.06.2021 Nature Publishing Group Nature Portfolio
Subjects:	14/63 49 49/47 631/337/1427 631/337/1427/2566 631/80 631/80/103/560 631/80/641/151 Cancer Cell cycle Cell Cycle - genetics Cell Line Cell Line, Tumor Deoxyribonucleic acid DNA DNA - genetics DNA - metabolism DNA biosynthesis DNA Damage DNA Repair DNA Replication - genetics Fragility Genomes HeLa Cells Humanities and Social Sciences Humans Lesions Microscopy, Confocal Mitosis - genetics multidisciplinary Protein A Proteins Repair Replication Replication protein A Replication Protein A - genetics Replication Protein A - metabolism Science Science (multidisciplinary) Shielding Shields Single-stranded DNA Synthesis Telomere - genetics Telomere - metabolism Telomeres Time-Lapse Imaging - methods Tumor Suppressor p53-Binding Protein 1 - genetics Tumor Suppressor p53-Binding Protein 1 - metabolism Yeast Zebrafish
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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