Coregulation of transcription factor binding and nucleosome occupancy through DNA features of mammalian enhancers

Transcription factors (TFs) preferentially bind sites contained in regions of computationally predicted high nucleosomal occupancy, suggesting that nucleosomes are gatekeepers of TF binding sites. However, because of their complexity mammalian genomes contain millions of randomly occurring, unbound...

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Veröffentlicht in:	Molecular cell Jg. 54; H. 5; S. 844
Hauptverfasser:	Barozzi, Iros, Simonatto, Marta, Bonifacio, Silvia, Yang, Lin, Rohs, Remo, Ghisletti, Serena, Natoli, Gioacchino
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 05.06.2014
Schlagworte:	Animals Base Sequence Binding Sites Cells, Cultured Consensus Sequence Enhancer Elements, Genetic Gene Expression Regulation Gene Knockdown Techniques Humans Mice Models, Genetic Nucleosomes - genetics Nucleosomes - metabolism Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism RNA, Small Interfering - genetics Sequence Analysis, DNA Support Vector Machine Trans-Activators - genetics Trans-Activators - metabolism
ISSN:	1097-4164, 1097-4164
Online-Zugang:	Weitere Angaben
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