Gli1 + mesenchymal stromal cells form a pathological niche to promote airway progenitor metaplasia in the fibrotic lung

Aberrant epithelial reprogramming can induce metaplastic differentiation at sites of tissue injury that culminates in transformed barriers composed of scar and metaplastic epithelium. While the plasticity of epithelial stem cells is well characterized, the identity and role of the niche has not been...

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Bibliographic Details
Published in:	Nature cell biology Vol. 22; no. 11; pp. 1295 - 1306
Main Authors:	Cassandras, Monica, Wang, Chaoqun, Kathiriya, Jaymin, Tsukui, Tatsuya, Matatia, Peri, Matthay, Michael, Wolters, Paul, Molofsky, Ari, Sheppard, Dean, Chapman, Hal, Peng, Tien
Format:	Journal Article
Language:	English
Published:	England Nature Publishing Group 01.11.2020
Subjects:	Alveolar Epithelial Cells - metabolism Alveolar Epithelial Cells - pathology Alveoli Animals Basal cells Bleomycin Bone Morphogenetic Proteins - metabolism Cell Differentiation Cells, Cultured Coculture Techniques Disease Models, Animal Epithelium Fibrosis Hedgehog protein Hedgehog Proteins - metabolism Keratin-5 - metabolism Lung - metabolism Lung - pathology Lungs Mesenchymal stem cells Mesenchymal Stem Cells - metabolism Mesenchymal Stem Cells - pathology Mesenchyme Metaplasia Mice, Inbred C57BL Mice, Knockout Pulmonary Fibrosis - chemically induced Pulmonary Fibrosis - genetics Pulmonary Fibrosis - metabolism Pulmonary Fibrosis - pathology Respiratory tract Scars Signal Transduction Signaling Smoothened Receptor - metabolism Stem Cell Niche Stem cells Stromal cells Zinc Finger Protein GLI1 - genetics Zinc Finger Protein GLI1 - metabolism
ISSN:	1465-7392, 1476-4679, 1476-4679
Online Access:	Get full text
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