Structural insights into the competitive inhibition of the ATP-gated P2X receptor channel

P2X receptors are non-selective cation channels gated by extracellular ATP, and the P2X7 receptor subtype plays a crucial role in the immune and nervous systems. Altered expression and dysfunctions of P2X7 receptors caused by genetic deletions, mutations, and polymorphic variations have been linked...

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Bibliographic Details
Published in:	Nature communications Vol. 8; no. 1; pp. 876 - 10
Main Authors:	Kasuya, Go, Yamaura, Toshiaki, Ma, Xiao-Bo, Nakamura, Ryoki, Takemoto, Mizuki, Nagumo, Hiromitsu, Tanaka, Eiichi, Dohmae, Naoshi, Nakane, Takanori, Yu, Ye, Ishitani, Ryuichiro, Matsuzaki, Osamu, Hattori, Motoyuki, Nureki, Osamu
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 12.10.2017 Nature Publishing Group Nature Portfolio
Subjects:	631/45/269/1149 631/535/1266 Arthritis Cations Channels Competition Computation Computer applications Conformation Crystal structure Electrophysiology Humanities and Social Sciences Hypertension multidisciplinary Mutation Receptors Rheumatoid arthritis Science Science (multidisciplinary)
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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