Epigenetic landscape of pancreatic neuroendocrine tumours reveals distinct cells of origin and means of tumour progression

Recent data suggest that Pancreatic Neuroendocrine Tumours (PanNETs) originate from α- or β-cells of the islets of Langerhans. The majority of PanNETs are non-functional and do not express cell-type specific hormones. In the current study we examine whether tumour DNA methylation (DNAme) profiling c...

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Vydáno v:Communications biology Ročník 3; číslo 1; s. 740 - 11
Hlavní autoři: Di Domenico, Annunziata, Pipinikas, Christodoulos P., Maire, Renaud S., Bräutigam, Konstantin, Simillion, Cedric, Dettmer, Matthias S., Vassella, Erik, Thirlwell, Chrissie, Perren, Aurel, Marinoni, Ilaria
Médium: Journal Article
Jazyk:angličtina
Vydáno: London Nature Publishing Group UK 07.12.2020
Nature Publishing Group
Nature Portfolio
Témata:
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45/22
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45/61
631/337/176/1988
631/67/1459/1963
631/67/68/2486
Beta cells
Biology
Biomedical and Life Sciences
Deoxyribonucleic acid
DNA
DNA Copy Number Variations
DNA fingerprinting
DNA methylation
Epigenesis, Genetic
Epigenetics
Gene Expression Regulation, Neoplastic - physiology
Genomes
High-Throughput Nucleotide Sequencing
Humans
Islets of Langerhans
Life Sciences
Neuroendocrine tumors
Neuroendocrine Tumors - genetics
Neuroendocrine Tumors - metabolism
Pancreas
Pancreatic Neoplasms - genetics
Pancreatic Neoplasms - metabolism
ISSN:2399-3642, 2399-3642
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Shrnutí:Recent data suggest that Pancreatic Neuroendocrine Tumours (PanNETs) originate from α- or β-cells of the islets of Langerhans. The majority of PanNETs are non-functional and do not express cell-type specific hormones. In the current study we examine whether tumour DNA methylation (DNAme) profiling combined with genomic data is able to identify cell of origin and to reveal pathways involved in PanNET progression. We analyse genome-wide DNAme data of 125 PanNETs and sorted α- and β-cells. To confirm cell identity, we investigate ARX and PDX1 expression. Based on epigenetic similarities, PanNETs cluster in α-like, β-like and intermediate tumours. The epigenetic similarity to α-cells progressively decreases in the intermediate tumours, which present unclear differentiation. Specific transcription factor methylation and expression vary in the respective α/β-tumour groups. Depending on DNAme similarity to α/β-cells, PanNETs have different mutational spectra, stage of the disease and prognosis, indicating potential means of PanNET progression. Di Domenico et al., provide a comprehensive assessment of DNA methylation in a large cohort of pancreatic neuroendocrine tumors. This work provides new insights into the epigenetic heterogeneity of the disease and cellular basis.
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ISSN:2399-3642
2399-3642
DOI:10.1038/s42003-020-01479-y