Epigenetic landscape of pancreatic neuroendocrine tumours reveals distinct cells of origin and means of tumour progression

Recent data suggest that Pancreatic Neuroendocrine Tumours (PanNETs) originate from α- or β-cells of the islets of Langerhans. The majority of PanNETs are non-functional and do not express cell-type specific hormones. In the current study we examine whether tumour DNA methylation (DNAme) profiling c...

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Bibliographic Details
Published in:	Communications biology Vol. 3; no. 1; pp. 740 - 11
Main Authors:	Di Domenico, Annunziata, Pipinikas, Christodoulos P., Maire, Renaud S., Bräutigam, Konstantin, Simillion, Cedric, Dettmer, Matthias S., Vassella, Erik, Thirlwell, Chrissie, Perren, Aurel, Marinoni, Ilaria
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 07.12.2020 Nature Publishing Group Nature Portfolio
Subjects:	13/51 45/22 45/43 45/61 631/337/176/1988 631/67/1459/1963 631/67/68/2486 Beta cells Biology Biomedical and Life Sciences Deoxyribonucleic acid DNA DNA Copy Number Variations DNA fingerprinting DNA methylation Epigenesis, Genetic Epigenetics Gene Expression Regulation, Neoplastic - physiology Genomes High-Throughput Nucleotide Sequencing Humans Islets of Langerhans Life Sciences Neuroendocrine tumors Neuroendocrine Tumors - genetics Neuroendocrine Tumors - metabolism Pancreas Pancreatic Neoplasms - genetics Pancreatic Neoplasms - metabolism
ISSN:	2399-3642, 2399-3642
Online Access:	Get full text
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