Low-dose metformin targets the lysosomal AMPK pathway through PEN2

Metformin, the most prescribed antidiabetic medicine, has shown other benefits such as anti-ageing and anticancer effects 1 – 4 . For clinical doses of metformin, AMP-activated protein kinase (AMPK) has a major role in its mechanism of action 4 , 5 ; however, the direct molecular target of metformin...

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Published in:	Nature (London) Vol. 603; no. 7899; pp. 159 - 165
Main Authors:	Ma, Teng, Tian, Xiao, Zhang, Baoding, Li, Mengqi, Wang, Yu, Yang, Chunyan, Wu, Jianfeng, Wei, Xiaoyan, Qu, Qi, Yu, Yaxin, Long, Shating, Feng, Jin-Wei, Li, Chun, Zhang, Cixiong, Xie, Changchuan, Wu, Yaying, Xu, Zheni, Chen, Junjie, Yu, Yong, Huang, Xi, He, Ying, Yao, Luming, Zhang, Lei, Zhu, Mingxia, Wang, Wen, Wang, Zhi-Chao, Zhang, Mingliang, Bao, Yuqian, Jia, Weiping, Lin, Shu-Yong, Ye, Zhiyun, Piao, Hai-Long, Deng, Xianming, Zhang, Chen-Song, Lin, Sheng-Cai
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 03.03.2022 Nature Publishing Group
Subjects:	13/1 13/109 13/44 13/51 13/95 14/19 14/28 140/131 38/77 631/443/319 631/80/86 64/11 64/60 82/103 82/80 Adenosine Triphosphatases - metabolism Aging AMP-activated protein kinase AMP-Activated Protein Kinases - metabolism Amyloid Precursor Protein Secretases Animals Antidiabetics Binding sites Caenorhabditis elegans - metabolism Chemoreception Diabetes Diabetes mellitus Diabetes Mellitus - drug therapy Dissociation Glucose Glucose - metabolism H+-transporting ATPase Humanities and Social Sciences Humans Hypoglycemic Agents - administration & dosage Hypoglycemic Agents - metabolism Hypoglycemic Agents - pharmacology Intestine Kinases Life span Localization Lysosomes - metabolism Mass spectrometry Membrane Proteins Metformin Metformin - agonists Metformin - metabolism Metformin - pharmacology Microscopy multidisciplinary Presenilin 2 Proteins Protons Science Science (multidisciplinary) Scientific imaging Signal transduction Vacuolar Proton-Translocating ATPases - metabolism
ISSN:	0028-0836, 1476-4687, 1476-4687
Online Access:	Get full text
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