CST1 inhibits ferroptosis and promotes gastric cancer metastasis by regulating GPX4 protein stability via OTUB1

Metastasis is an important factor contributing to poor prognosis in patients with gastric cancer; yet, the molecular mechanism leading to this cell behavior is still not well understood. In this study, we explored the role of cysteine protease inhibitor SN (Cystatin SN, CST1) in promoting gastric ca...

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Veröffentlicht in:	Oncogene Jg. 42; H. 2; S. 83 - 98
Hauptverfasser:	Li, Dongbao, Wang, Yuhong, Dong, Chao, Chen, Tao, Dong, Anqi, Ren, Jiayu, Li, Weikang, Shu, Gege, Yang, Jiaoyang, Shen, Wenhao, Qin, Lei, Hu, Lin, Zhou, Jin
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 05.01.2023 Nature Publishing Group
Schlagworte:	13 13/51 13/89 38 631/67/1504/1829 692/53/2422 82 82/1 82/58 82/80 Animals Apoptosis Ascites Cell Biology Cell Line, Tumor Cystatins Cysteine proteinase Ferroptosis Ferroptosis - genetics Gastric cancer Human Genetics Immunoprecipitation Internal Medicine Mass spectroscopy Medicine Medicine & Public Health Mesenchyme Metastases Metastasis Mice Mice, Nude Oncology Peripheral blood Prognosis Proteinase inhibitors Proteins Reactive oxygen species Risk factors Salivary Cystatins - metabolism Stomach Neoplasms - pathology Therapeutic targets Transcriptomes Ubiquitination
ISSN:	0950-9232, 1476-5594, 1476-5594
Online-Zugang:	Volltext
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