CAR T cells redirected to cell surface GRP78 display robust anti-acute myeloid leukemia activity and do not target hematopoietic progenitor cells

Developing CAR T cells for acute myeloid leukemia (AML) has been hampered by a paucity of targets that are expressed on AML blasts and not on hematopoietic progenitor cells (HPCs). Here we demonstrate that GRP78 is expressed on the cell surface of primary AML blasts but not HPCs. To target GRP78, we...

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Bibliographic Details
Published in:	Nature communications Vol. 13; no. 1; pp. 587 - 14
Main Authors:	Hebbar, Nikhil, Epperly, Rebecca, Vaidya, Abishek, Thanekar, Unmesha, Moore, Sarah E., Umeda, Masayuki, Ma, Jing, Patil, Sagar L., Langfitt, Deanna, Huang, Sujuan, Cheng, Cheng, Klco, Jeffery M., Gottschalk, Stephen, Velasquez, M. Paulina
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 31.01.2022 Nature Publishing Group Nature Portfolio
Subjects:	13 13/106 13/21 13/31 42 631/250/251 631/67/1059/2325 692/4028/67/1990 Acute myeloid leukemia Animals Antigens Biocompatibility Cell activation Cell differentiation Cell Line, Tumor Cell Membrane - drug effects Cell Membrane - metabolism Cell surface Cell Survival - drug effects Cytokines - metabolism Cytotoxicity, Immunologic - drug effects Dasatinib - pharmacology Differentiation (biology) Endoplasmic Reticulum Chaperone BiP - immunology Gene Expression Regulation, Leukemic - drug effects Hematopoietic stem cells Hematopoietic Stem Cells - immunology Humanities and Social Sciences Humans Leukemia Leukemia, Myeloid, Acute - genetics Leukemia, Myeloid, Acute - immunology Lymphocytes Lymphocytes T Mice Mice, Inbred NOD Mice, SCID multidisciplinary Peptides Progenitor cells Protein folding Receptors, Chimeric Antigen - immunology Science Science (multidisciplinary) Signal transduction T-Lymphocytes - drug effects T-Lymphocytes - immunology Toxicity Xenograft Model Antitumor Assays
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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