Global gene expression analysis of systemic sclerosis myofibroblasts demonstrates a marked increase in the expression of multiple NBPF genes

Myofibroblasts are the key effector cells responsible for the exaggerated tissue fibrosis in Systemic Sclerosis (SSc). Despite their importance to SSc pathogenesis, the specific transcriptome of SSc myofibroblasts has not been described. The purpose of this study was to identify transcriptome differ...

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Veröffentlicht in:	Scientific reports Jg. 11; H. 1; S. 20435 - 8
Hauptverfasser:	Abignano, Giuseppina, Hermes, Heidi, Piera-Velazquez, Sonsoles, Addya, Sankar, Del Galdo, Francesco, Jimenez, Sergio A.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 14.10.2021 Nature Publishing Group Nature Portfolio
Schlagworte:	631/1647/2017/2003 631/1647/2017/2079 692/699/1670/122/1801 Actin Adult Blotting, Western Case-Control Studies Cell lineage DNA microarrays Effector cells Female Fibroblasts Fibrosis Gene expression Gene Expression Profiling Genes, Neoplasm Genomes Humanities and Social Sciences Humans Immunohistochemistry Laser Capture Microdissection Male multidisciplinary Myofibroblasts - metabolism Neoplasm Proteins - genetics Neuroblastoma Pathogenesis Real-Time Polymerase Chain Reaction Science Science (multidisciplinary) Scleroderma Scleroderma, Systemic - genetics Scleroderma, Systemic - metabolism Skin - metabolism Smooth muscle Systemic sclerosis Therapeutic targets Transcriptomes Transforming Growth Factor beta - metabolism Western blotting
ISSN:	2045-2322, 2045-2322
Online-Zugang:	Volltext
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