Global gene expression analysis of systemic sclerosis myofibroblasts demonstrates a marked increase in the expression of multiple NBPF genes

Myofibroblasts are the key effector cells responsible for the exaggerated tissue fibrosis in Systemic Sclerosis (SSc). Despite their importance to SSc pathogenesis, the specific transcriptome of SSc myofibroblasts has not been described. The purpose of this study was to identify transcriptome differ...

Celý popis

Uloženo v:

Podrobná bibliografie
Vydáno v:	Scientific reports Ročník 11; číslo 1; s. 20435 - 8
Hlavní autoři:	Abignano, Giuseppina, Hermes, Heidi, Piera-Velazquez, Sonsoles, Addya, Sankar, Del Galdo, Francesco, Jimenez, Sergio A.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	London Nature Publishing Group UK 14.10.2021 Nature Publishing Group Nature Portfolio
Témata:	631/1647/2017/2003 631/1647/2017/2079 692/699/1670/122/1801 Actin Adult Blotting, Western Case-Control Studies Cell lineage DNA microarrays Effector cells Female Fibroblasts Fibrosis Gene expression Gene Expression Profiling Genes, Neoplasm Genomes Humanities and Social Sciences Humans Immunohistochemistry Laser Capture Microdissection Male multidisciplinary Myofibroblasts - metabolism Neoplasm Proteins - genetics Neuroblastoma Pathogenesis Real-Time Polymerase Chain Reaction Science Science (multidisciplinary) Scleroderma Scleroderma, Systemic - genetics Scleroderma, Systemic - metabolism Skin - metabolism Smooth muscle Systemic sclerosis Therapeutic targets Transcriptomes Transforming Growth Factor beta - metabolism Western blotting
ISSN:	2045-2322, 2045-2322
On-line přístup:	Získat plný text
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!

Abstract	Myofibroblasts are the key effector cells responsible for the exaggerated tissue fibrosis in Systemic Sclerosis (SSc). Despite their importance to SSc pathogenesis, the specific transcriptome of SSc myofibroblasts has not been described. The purpose of this study was to identify transcriptome differences between SSc myofibroblasts and non-myofibroblastic cells. Alpha smooth muscle actin (α-SMA) expressing myofibroblasts and α-SMA negative cells were isolated employing laser capture microdissection from dermal cell cultures from four patients with diffuse SSc of recent onset. Total mRNA was extracted from both cell populations, amplified and analyzed employing microarrays. Results for specific genes were validated by Western blots and by immunohistochemistry. Transcriptome analysis revealed 97 differentially expressed transcripts in SSc myofibroblasts compared with non-myofibroblasts. Annotation clustering of the SSc myofibroblast-specific transcripts failed to show a TGF-β signature. The most represented transcripts corresponded to several different genes from the Neuroblastoma Breakpoint Family (NBPF) of genes. NBPF genes are highly expanded in humans but are not present in murine or rat genomes. In vitro studies employing cultured SSc dermal fibroblasts and immunohistochemistry of affected SSc skin confirmed increased NBPF expression in SSc. These results indicate that SSc myofibroblasts represent a unique cell lineage expressing a specific transcriptome that includes very high levels of transcripts corresponding to numerous NBPF genes. Elevated expression of NBPF genes in SSc myofibroblasts suggests that NBPF gene products may play a role in SSc pathogenesis and may represent a novel therapeutic target.
AbstractList	Myofibroblasts are the key effector cells responsible for the exaggerated tissue fibrosis in Systemic Sclerosis (SSc). Despite their importance to SSc pathogenesis, the specific transcriptome of SSc myofibroblasts has not been described. The purpose of this study was to identify transcriptome differences between SSc myofibroblasts and non-myofibroblastic cells. Alpha smooth muscle actin (α-SMA) expressing myofibroblasts and α-SMA negative cells were isolated employing laser capture microdissection from dermal cell cultures from four patients with diffuse SSc of recent onset. Total mRNA was extracted from both cell populations, amplified and analyzed employing microarrays. Results for specific genes were validated by Western blots and by immunohistochemistry. Transcriptome analysis revealed 97 differentially expressed transcripts in SSc myofibroblasts compared with non-myofibroblasts. Annotation clustering of the SSc myofibroblast-specific transcripts failed to show a TGF-β signature. The most represented transcripts corresponded to several different genes from the Neuroblastoma Breakpoint Family (NBPF) of genes. NBPF genes are highly expanded in humans but are not present in murine or rat genomes. In vitro studies employing cultured SSc dermal fibroblasts and immunohistochemistry of affected SSc skin confirmed increased NBPF expression in SSc. These results indicate that SSc myofibroblasts represent a unique cell lineage expressing a specific transcriptome that includes very high levels of transcripts corresponding to numerous NBPF genes. Elevated expression of NBPF genes in SSc myofibroblasts suggests that NBPF gene products may play a role in SSc pathogenesis and may represent a novel therapeutic target. Abstract Myofibroblasts are the key effector cells responsible for the exaggerated tissue fibrosis in Systemic Sclerosis (SSc). Despite their importance to SSc pathogenesis, the specific transcriptome of SSc myofibroblasts has not been described. The purpose of this study was to identify transcriptome differences between SSc myofibroblasts and non-myofibroblastic cells. Alpha smooth muscle actin (α-SMA) expressing myofibroblasts and α-SMA negative cells were isolated employing laser capture microdissection from dermal cell cultures from four patients with diffuse SSc of recent onset. Total mRNA was extracted from both cell populations, amplified and analyzed employing microarrays. Results for specific genes were validated by Western blots and by immunohistochemistry. Transcriptome analysis revealed 97 differentially expressed transcripts in SSc myofibroblasts compared with non-myofibroblasts. Annotation clustering of the SSc myofibroblast-specific transcripts failed to show a TGF-β signature. The most represented transcripts corresponded to several different genes from the Neuroblastoma Breakpoint Family (NBPF) of genes. NBPF genes are highly expanded in humans but are not present in murine or rat genomes. In vitro studies employing cultured SSc dermal fibroblasts and immunohistochemistry of affected SSc skin confirmed increased NBPF expression in SSc. These results indicate that SSc myofibroblasts represent a unique cell lineage expressing a specific transcriptome that includes very high levels of transcripts corresponding to numerous NBPF genes. Elevated expression of NBPF genes in SSc myofibroblasts suggests that NBPF gene products may play a role in SSc pathogenesis and may represent a novel therapeutic target. Myofibroblasts are the key effector cells responsible for the exaggerated tissue fibrosis in Systemic Sclerosis (SSc). Despite their importance to SSc pathogenesis, the specific transcriptome of SSc myofibroblasts has not been described. The purpose of this study was to identify transcriptome differences between SSc myofibroblasts and non-myofibroblastic cells. Alpha smooth muscle actin (α-SMA) expressing myofibroblasts and α-SMA negative cells were isolated employing laser capture microdissection from dermal cell cultures from four patients with diffuse SSc of recent onset. Total mRNA was extracted from both cell populations, amplified and analyzed employing microarrays. Results for specific genes were validated by Western blots and by immunohistochemistry. Transcriptome analysis revealed 97 differentially expressed transcripts in SSc myofibroblasts compared with non-myofibroblasts. Annotation clustering of the SSc myofibroblast-specific transcripts failed to show a TGF-β signature. The most represented transcripts corresponded to several different genes from the Neuroblastoma Breakpoint Family (NBPF) of genes. NBPF genes are highly expanded in humans but are not present in murine or rat genomes. In vitro studies employing cultured SSc dermal fibroblasts and immunohistochemistry of affected SSc skin confirmed increased NBPF expression in SSc. These results indicate that SSc myofibroblasts represent a unique cell lineage expressing a specific transcriptome that includes very high levels of transcripts corresponding to numerous NBPF genes. Elevated expression of NBPF genes in SSc myofibroblasts suggests that NBPF gene products may play a role in SSc pathogenesis and may represent a novel therapeutic target.Myofibroblasts are the key effector cells responsible for the exaggerated tissue fibrosis in Systemic Sclerosis (SSc). Despite their importance to SSc pathogenesis, the specific transcriptome of SSc myofibroblasts has not been described. The purpose of this study was to identify transcriptome differences between SSc myofibroblasts and non-myofibroblastic cells. Alpha smooth muscle actin (α-SMA) expressing myofibroblasts and α-SMA negative cells were isolated employing laser capture microdissection from dermal cell cultures from four patients with diffuse SSc of recent onset. Total mRNA was extracted from both cell populations, amplified and analyzed employing microarrays. Results for specific genes were validated by Western blots and by immunohistochemistry. Transcriptome analysis revealed 97 differentially expressed transcripts in SSc myofibroblasts compared with non-myofibroblasts. Annotation clustering of the SSc myofibroblast-specific transcripts failed to show a TGF-β signature. The most represented transcripts corresponded to several different genes from the Neuroblastoma Breakpoint Family (NBPF) of genes. NBPF genes are highly expanded in humans but are not present in murine or rat genomes. In vitro studies employing cultured SSc dermal fibroblasts and immunohistochemistry of affected SSc skin confirmed increased NBPF expression in SSc. These results indicate that SSc myofibroblasts represent a unique cell lineage expressing a specific transcriptome that includes very high levels of transcripts corresponding to numerous NBPF genes. Elevated expression of NBPF genes in SSc myofibroblasts suggests that NBPF gene products may play a role in SSc pathogenesis and may represent a novel therapeutic target.
ArticleNumber	20435
Author	Hermes, Heidi Del Galdo, Francesco Addya, Sankar Jimenez, Sergio A. Piera-Velazquez, Sonsoles Abignano, Giuseppina
Author_xml	– sequence: 1 givenname: Giuseppina surname: Abignano fullname: Abignano, Giuseppina organization: Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust – sequence: 2 givenname: Heidi surname: Hermes fullname: Hermes, Heidi organization: Jefferson Institute of Molecular Medicine and Scleroderma Center, Thomas Jefferson University – sequence: 3 givenname: Sonsoles surname: Piera-Velazquez fullname: Piera-Velazquez, Sonsoles organization: Jefferson Institute of Molecular Medicine and Scleroderma Center, Thomas Jefferson University – sequence: 4 givenname: Sankar surname: Addya fullname: Addya, Sankar organization: Center for Genomics, Kimmel Cancer Center, Thomas Jefferson University – sequence: 5 givenname: Francesco surname: Del Galdo fullname: Del Galdo, Francesco email: f.delgaldo@leeds.ac.uk organization: Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust – sequence: 6 givenname: Sergio A. surname: Jimenez fullname: Jimenez, Sergio A. email: sergio.jimenez@jefferson.edu organization: Jefferson Institute of Molecular Medicine and Scleroderma Center, Thomas Jefferson University
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/34650102$$D View this record in MEDLINE/PubMed
BookMark	eNp9ksFu1DAQhiNURMvSF-CALHHhErAd24kvSLSipVIFHOBsOc5k68WxF9uLyDvw0Hh3S-n20FxiTf7_m9-ZeV4d-eChql4S_JbgpnuXGOGyqzEltZRU0np-Up1QzHhNG0qP7p2Pq9OUVrg8nEpG5LPquGGCY4LpSfXn0oVeO7QEDwh-ryOkZINH2ms3J5tQGFGaU4bJGpSMgxi21WkOo-1j6J1OOaEBpuBTjjpDQhpNOv6AAVlvIugE5YDyzQG-UKeNy3btAH0--3qx659eVE9H7RKc3r4X1feLj9_OP9XXXy6vzj9c14YznGuqZdsZInTXAmc963krjBkYx4IIJvRgiMTdWMQ9lk0zCkqGgbW6FaMRo2DNorrac4egV2odbQk8q6Ct2hVCXCodsy23VXigUraakUYKVhoW7Eh7MJ0uxUItrPd71nrTTzAY8OU3uAPo4Rdvb9Qy_FIdJ0KWfIvqzS0ghp8bSFlNNhlwTnsIm6Qo72hX2pOt9PUD6SpsYpnUTkWk4LLZJnp1P9FdlH9DLwK6F5gyzBRhvJMQrLbLpfbLpcpyqd1yqbmYugcmY7POZZjlVtY9bm321lT6-CXE_7Efcf0FJu7nDw
CitedBy_id	crossref_primary_10_1186_s13075_022_02779_w crossref_primary_10_1007_s10067_024_07123_y
Cites_doi	10.1016/j.yexcr.2019.03.027 10.1002/art.39421 10.1016/S0140-6736(17)30933-9 10.2741/s22 10.1038/nrm809 10.1056/NEJMra0806188 10.5152/eurjrheum.2019.19081 10.1007/BF03403533 10.1136/annrheumdis-2018-214865 10.1186/1479-7364-5-2-99 10.1007/s00441-016-2464-0 10.1038/s41598-019-41153-w 10.1002/art.23791 10.1089/089277903322145530 10.1016/j.biocel.2013.07.022 10.1136/annrheumdis-2013-204424 10.1172/JCI31139 10.1007/s00018-015-2110-0 10.1042/bj2370837 10.1002/path.1427 10.1016/j.ajpath.2012.02.004 10.1097/BOR.0000000000000543 10.1007/s11926-007-0008-z 10.1371/journal.pone.0002207 10.1016/j.cell.2009.11.007 10.2174/157339710793205611 10.1016/j.trsl.2019.02.010 10.1038/labinvest.3700654 10.1016/j.matbio.2018.01.025 10.3389/fimmu.2018.02452 10.1038/ncprheum0115 10.1136/annrheumdis-2019-216542 10.1002/art.22186 10.1016/j.autrev.2013.04.004 10.1155/2013/835948 10.1136/annrheumdis-2016-210229 10.1093/molbev/msi222 10.1038/nrrheum.2014.137 10.1016/j.humpath.2009.02.020 10.1002/jcp.25879 10.1152/physrev.00021.2018 10.1016/j.ajhg.2012.07.016 10.1136/ard.2010.134858 10.1038/nrdp.2015.2 10.1002/path.4253
ContentType	Journal Article
Copyright	The Author(s) 2021 2021. The Author(s). The Author(s) 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
Copyright_xml	– notice: The Author(s) 2021 – notice: 2021. The Author(s). – notice: The Author(s) 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
DBID	C6C AAYXX CITATION CGR CUY CVF ECM EIF NPM 3V. 7X7 7XB 88A 88E 88I 8FE 8FH 8FI 8FJ 8FK ABUWG AEUYN AFKRA AZQEC BBNVY BENPR BHPHI CCPQU DWQXO FYUFA GHDGH GNUQQ HCIFZ K9. LK8 M0S M1P M2P M7P PHGZM PHGZT PIMPY PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PRINS Q9U 7X8 5PM DOA
DOI	10.1038/s41598-021-99292-y
DatabaseName	Springer Nature OA Free Journals CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) Health & Medical Collection ProQuest Central (purchase pre-March 2016) Biology Database (Alumni Edition) Medical Database (Alumni Edition) Science Database (Alumni Edition) ProQuest SciTech Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest One Sustainability (subscription) ProQuest Central UK/Ireland ProQuest Central Essentials Biological Science Collection ProQuest Central Natural Science Collection ProQuest One Community College ProQuest Central Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) ProQuest Biological Science Collection Health & Medical Collection (Alumni Edition) PML(ProQuest Medical Library) Science Database Biological Science Database ProQuest Central Premium ProQuest One Academic Publicly Available Content Database ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic (retired) ProQuest One Academic UKI Edition ProQuest Central China ProQuest Central Basic MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals
DatabaseTitle	CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Publicly Available Content Database ProQuest Central Student ProQuest One Academic Middle East (New) ProQuest Central Essentials ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) SciTech Premium Collection ProQuest One Community College ProQuest One Health & Nursing ProQuest Natural Science Collection ProQuest Central China ProQuest Biology Journals (Alumni Edition) ProQuest Central ProQuest One Applied & Life Sciences ProQuest One Sustainability ProQuest Health & Medical Research Collection Health Research Premium Collection Health and Medicine Complete (Alumni Edition) Natural Science Collection ProQuest Central Korea Health & Medical Research Collection Biological Science Collection ProQuest Central (New) ProQuest Medical Library (Alumni) ProQuest Science Journals (Alumni Edition) ProQuest Biological Science Collection ProQuest Central Basic ProQuest Science Journals ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) Biological Science Database ProQuest SciTech Collection ProQuest Hospital Collection (Alumni) ProQuest Health & Medical Complete ProQuest Medical Library ProQuest One Academic UKI Edition ProQuest One Academic ProQuest One Academic (New) ProQuest Central (Alumni) MEDLINE - Academic
DatabaseTitleList	Publicly Available Content Database CrossRef MEDLINE MEDLINE - Academic
Database_xml	– sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: PIMPY name: Publicly Available Content Database url: http://search.proquest.com/publiccontent sourceTypes: Aggregation Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Biology
EISSN	2045-2322
EndPage	8
ExternalDocumentID	oai_doaj_org_article_0d2997a413964a878fcf2bec8a7a4dd4 PMC8516909 34650102 10_1038_s41598_021_99292_y
Genre	Research Support, Non-U.S. Gov't Journal Article Research Support, N.I.H., Extramural
GrantInformation_xml	– fundername: EULAR ODP – fundername: NIH/NIAMS grantid: RO-119616 – fundername: NIAMS NIH HHS grantid: RO-119616 – fundername: Department of Health – fundername: ; – fundername: ; grantid: RO-119616
GroupedDBID	0R~ 3V. 4.4 53G 5VS 7X7 88A 88E 88I 8FE 8FH 8FI 8FJ AAFWJ AAJSJ AAKDD ABDBF ABUWG ACGFS ACSMW ACUHS ADBBV ADRAZ AENEX AEUYN AFKRA AJTQC ALIPV ALMA_UNASSIGNED_HOLDINGS AOIJS AZQEC BAWUL BBNVY BCNDV BENPR BHPHI BPHCQ BVXVI C6C CCPQU DIK DWQXO EBD EBLON EBS ESX FYUFA GNUQQ GROUPED_DOAJ GX1 HCIFZ HH5 HMCUK HYE KQ8 LK8 M0L M1P M2P M48 M7P M~E NAO OK1 PIMPY PQQKQ PROAC PSQYO RNT RNTTT RPM SNYQT UKHRP AASML AAYXX AFFHD AFPKN CITATION PHGZM PHGZT PJZUB PPXIY PQGLB CGR CUY CVF ECM EIF NPM 7XB 8FK K9. PKEHL PQEST PQUKI PRINS Q9U 7X8 5PM
ID	FETCH-LOGICAL-c540t-2a978c16a87e54b4b576ccd45061646adc1908fc54b0933f621dd47a76fc6f643
IEDL.DBID	DOA
ISICitedReferencesCount	3
ISICitedReferencesURI	http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000707419500083&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN	2045-2322
IngestDate	Tue Oct 14 19:08:16 EDT 2025 Tue Nov 04 01:53:48 EST 2025 Sun Nov 09 11:20:27 EST 2025 Tue Oct 07 07:44:12 EDT 2025 Thu Jan 02 22:56:28 EST 2025 Sat Nov 29 02:50:31 EST 2025 Tue Nov 18 22:30:28 EST 2025 Fri Feb 21 02:39:31 EST 2025
IsDoiOpenAccess	true
IsOpenAccess	true
IsPeerReviewed	true
IsScholarly	true
Issue	1
Language	English
License	2021. The Author(s). Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-c540t-2a978c16a87e54b4b576ccd45061646adc1908fc54b0933f621dd47a76fc6f643
Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23
OpenAccessLink	https://doaj.org/article/0d2997a413964a878fcf2bec8a7a4dd4
PMID	34650102
PQID	2581965934
PQPubID	2041939
PageCount	8
ParticipantIDs	doaj_primary_oai_doaj_org_article_0d2997a413964a878fcf2bec8a7a4dd4 pubmedcentral_primary_oai_pubmedcentral_nih_gov_8516909 proquest_miscellaneous_2582813919 proquest_journals_2581965934 pubmed_primary_34650102 crossref_primary_10_1038_s41598_021_99292_y crossref_citationtrail_10_1038_s41598_021_99292_y springer_journals_10_1038_s41598_021_99292_y
PublicationCentury	2000
PublicationDate	2021-10-14
PublicationDateYYYYMMDD	2021-10-14
PublicationDate_xml	– month: 10 year: 2021 text: 2021-10-14 day: 14
PublicationDecade	2020
PublicationPlace	London
PublicationPlace_xml	– name: London – name: England
PublicationTitle	Scientific reports
PublicationTitleAbbrev	Sci Rep
PublicationTitleAlternate	Sci Rep
PublicationYear	2021
Publisher	Nature Publishing Group UK Nature Publishing Group Nature Portfolio
Publisher_xml	– name: Nature Publishing Group UK – name: Nature Publishing Group – name: Nature Portfolio
References	Bellini, Mattoli (CR15) 2007; 87 Guarino, Tosoni, Nebuloni (CR17) 2009; 40 Kramann, DiRocco, Humphreys (CR24) 2013; 231 Jimenez, Feldman, Bashey, Bienkowski, Rosenbloom (CR43) 1986; 237 Chadli (CR40) 2019; 9 Hinz (CR7) 2012; 180 Bucala, Spiegel, Chesney, Hogan, Cerami (CR14) 1994; 1 Jimenez (CR20) 2013; 2013 Zhou (CR30) 2013; 45 Vandepoele, Van Roy, Staes, Speleman, van Roy (CR27) 2005; 22 Denton, Black, Abraham (CR35) 2006; 2 Dumas (CR29) 2012; 91 Denton, Khanna (CR3) 2017; 390 Korman (CR13) 2019; 209 Thiery, Acloque, Huang, Nieto (CR16) 2009; 139 Jimenez, Castro, Piera-Velazquez (CR37) 2010; 6 Varga, Whitfield (CR36) 2009; 1 Schulz (CR34) 2018; 68–69 Kissin, Merkel, Lafyatis (CR12) 2006; 54 Hinz, Mc Cullock, Coehlo (CR33) 2019; 379 Gabbiani (CR5) 2003; 200 Yannick, Simms, Distler, Trojanowska, Pope, Denton (CR2) 2015; 1 Stone (CR18) 2016; 365 Tadros, Ruiz-Deya, Crawford, Thomas, Abdel-Mageed (CR45) 2003; 17 Gyftaki-Venieri, Abraham, Ponticos (CR10) 2018; 30 Gabrielli, Avvedimento, Krieg (CR1) 2009; 360 Rosa, Romano, Fioretto, Manetti (CR19) 2020; 7 van Caam, Vonk, van den Hoogen, van Lent, van der Kraan (CR11) 2018; 9 Piera-Velazquez, Jimenez (CR23) 2019; 99 Tomasek, Gabbiani, Hinz, Chaponnier, Brown (CR6) 2002; 3 Manetti (CR21) 2017; 76 Abraham, Eckes, Rajkumar, Krieg (CR9) 2007; 9 Valenzi (CR25) 2019; 78 van den Hoogen (CR41) 2013; 72 Cooper, Kehrer-Sawatzki (CR31) 2011; 5 LeRoy (CR42) 1988; 15 Del Galdo, Wermuth, Addya, Fortina, Jimenez (CR46) 2010; 69 Mendoza, Piera-Velazquez, Farber, Feghali-Bostwick, Jimenez (CR22) 2016; 68 Wasson (CR26) 2020; 79 Varga, Abraham (CR4) 2007; 117 Vandepoele (CR28) 2008; 3 Carthy (CR39) 2018; 233 Lafyatis (CR38) 2014; 10 Jimenez, Piera-Velazquez (CR32) 2013; 12 Del Galdo (CR44) 2008; 58 Darby, Zakuan, Billet, Desmoulière (CR8) 2016; 73 K Vandepoele (99292_CR28) 2008; 3 R Kramann (99292_CR24) 2013; 231 JN Schulz (99292_CR34) 2018; 68–69 I Rosa (99292_CR19) 2020; 7 CP Denton (99292_CR35) 2006; 2 A Gabrielli (99292_CR1) 2009; 360 DA Gyftaki-Venieri (99292_CR10) 2018; 30 IA Darby (99292_CR8) 2016; 73 K Vandepoele (99292_CR27) 2005; 22 EC LeRoy (99292_CR42) 1988; 15 SA Jimenez (99292_CR32) 2013; 12 Y Tadros (99292_CR45) 2003; 17 M Guarino (99292_CR17) 2009; 40 B Hinz (99292_CR7) 2012; 180 B Korman (99292_CR13) 2019; 209 G Gabbiani (99292_CR5) 2003; 200 L Chadli (99292_CR40) 2019; 9 DJ Abraham (99292_CR9) 2007; 9 J Varga (99292_CR36) 2009; 1 JM Carthy (99292_CR39) 2018; 233 FA Mendoza (99292_CR22) 2016; 68 CP Denton (99292_CR3) 2017; 390 EY Kissin (99292_CR12) 2006; 54 J Varga (99292_CR4) 2007; 117 A van Caam (99292_CR11) 2018; 9 SA Jimenez (99292_CR43) 1986; 237 F Del Galdo (99292_CR46) 2010; 69 JJ Tomasek (99292_CR6) 2002; 3 CW Wasson (99292_CR26) 2020; 79 SA Jimenez (99292_CR20) 2013; 2013 SA Jimenez (99292_CR37) 2010; 6 M Manetti (99292_CR21) 2017; 76 A Piera-Velazquez (99292_CR23) 2019; 99 R Bucala (99292_CR14) 1994; 1 F Del Galdo (99292_CR44) 2008; 58 R Stone (99292_CR18) 2016; 365 F Zhou (99292_CR30) 2013; 45 A Bellini (99292_CR15) 2007; 87 B Hinz (99292_CR33) 2019; 379 E Valenzi (99292_CR25) 2019; 78 LJ Dumas (99292_CR29) 2012; 91 F van den Hoogen (99292_CR41) 2013; 72 A Yannick (99292_CR2) 2015; 1 DN Cooper (99292_CR31) 2011; 5 R Lafyatis (99292_CR38) 2014; 10 JP Thiery (99292_CR16) 2009; 139
References_xml	– volume: 379 start-page: 119 year: 2019 end-page: 128 ident: CR33 article-title: Mechanical regulation of myofibroblast phenocon version and collagen contraction publication-title: Exp. Cell Res. doi: 10.1016/j.yexcr.2019.03.027 – volume: 68 start-page: 210 year: 2016 end-page: 217 ident: CR22 article-title: Endothelial cells expressing endothelial and mesenchymal cell gene products in lung tissue from patients with systemic sclerosis-associated interstitial lung disease publication-title: Arthritis Rheumatol. doi: 10.1002/art.39421 – volume: 390 start-page: 1685 year: 2017 end-page: 1699 ident: CR3 article-title: Systemic sclerosis publication-title: Lancet doi: 10.1016/S0140-6736(17)30933-9 – volume: 1 start-page: 226 year: 2009 end-page: 235 ident: CR36 article-title: Transforming growth factor-beta in systemic sclerosis (scleroderma) publication-title: Front. Biosci. (Sch. Ed.) doi: 10.2741/s22 – volume: 3 start-page: 349 year: 2002 end-page: 363 ident: CR6 article-title: Myofibroblasts and mechano-regulation of connective tissue remodeling publication-title: Nat. Rev. Mol. Cell. Biol. doi: 10.1038/nrm809 – volume: 360 start-page: 1989 year: 2009 end-page: 2003 ident: CR1 article-title: Scleroderma publication-title: N. Engl. J. Med. doi: 10.1056/NEJMra0806188 – volume: 7 start-page: S157 year: 2020 end-page: S164 ident: CR19 article-title: The contribution of mesenchymal transitions to the pathogenesis of systemic sclerosis publication-title: Eur. J. Rheumatol. doi: 10.5152/eurjrheum.2019.19081 – volume: 1 start-page: 71 year: 1994 end-page: 81 ident: CR14 article-title: Circulating fibrocytes define a new leukocyte subpopulation that mediates tissue repair publication-title: Mol. Med. doi: 10.1007/BF03403533 – volume: 78 start-page: 1379 year: 2019 end-page: 1387 ident: CR25 article-title: Single-cell analysis reveals fibroblast heterogeneity and myofibroblasts in systemic sclerosis-associated interstitial lung disease publication-title: Ann. Rheum. Dis. doi: 10.1136/annrheumdis-2018-214865 – volume: 5 start-page: 99 year: 2011 end-page: 107 ident: CR31 article-title: Exploring the potential relevance of human-specific genes to complex disease publication-title: Hum. Genom. doi: 10.1186/1479-7364-5-2-99 – volume: 365 start-page: 495 year: 2016 end-page: 506 ident: CR18 article-title: Epithelial-mesenchymal transition in tissue repair and fibrosis publication-title: Cell Tissue Res. doi: 10.1007/s00441-016-2464-0 – volume: 9 start-page: 4521 year: 2019 ident: CR40 article-title: Identification of regulators of the myofibroblast phenotype of primary dermal fibroblasts from early diffuse systemic sclerosis patients publication-title: Sci. Rep. doi: 10.1038/s41598-019-41153-w – volume: 58 start-page: 2854 year: 2008 end-page: 2865 ident: CR44 article-title: Decreased expression of caveolin 1 in patients with systemic sclerosis: crucial role in the pathogenesis of tissue fibrosis publication-title: Arthritis Rheum. doi: 10.1002/art.23791 – volume: 17 start-page: 333 year: 2003 end-page: 336 ident: CR45 article-title: In vivo proteomic analysis of cytokine expression in laser capture-microdissected urothelial cells of obstructed ureteropelvic junction procured by laparoscopic dismembered pyeloplasty publication-title: J. Endourol. doi: 10.1089/089277903322145530 – volume: 45 start-page: 2479 year: 2013 end-page: 2490 ident: CR30 article-title: NBPF is a potential DNA-binding transcription factor that is directly regulated by NF-kB publication-title: Int. J. Biochem. Cell Biol. doi: 10.1016/j.biocel.2013.07.022 – volume: 72 start-page: 1747 year: 2013 end-page: 1755 ident: CR41 article-title: 2013 classification criteria for systemic sclerosis: An American college rheumatology/European league against rheumatism collaborative initiative publication-title: Ann. Rheum. Dis. doi: 10.1136/annrheumdis-2013-204424 – volume: 117 start-page: 557 year: 2007 end-page: 567 ident: CR4 article-title: Systemic sclerosis: A prototypic multisystem fibrotic disorder publication-title: J. Clin. Invest. doi: 10.1172/JCI31139 – volume: 73 start-page: 1145 year: 2016 end-page: 1157 ident: CR8 article-title: The myofibroblast, a key cell in normal and pathological tissue repair publication-title: Cell. Mol. Life Sci. doi: 10.1007/s00018-015-2110-0 – volume: 237 start-page: 837 year: 1986 end-page: 843 ident: CR43 article-title: Co-ordinate increase in the expression of type I and type III collagen genes in progressive systemic sclerosis fibroblasts publication-title: Biochem. J. doi: 10.1042/bj2370837 – volume: 200 start-page: 500 year: 2003 end-page: 503 ident: CR5 article-title: The myofibroblast in wound healing and fibrocontractive diseases publication-title: J. Pathol. doi: 10.1002/path.1427 – volume: 180 start-page: 1340 year: 2012 end-page: 1355 ident: CR7 article-title: Recent developments in myofibroblast biology: Paradigms for connective tissue remodeling publication-title: Am. J. Pathol. doi: 10.1016/j.ajpath.2012.02.004 – volume: 30 start-page: 581 year: 2018 end-page: 587 ident: CR10 article-title: Insights into myofibroblasts and their activation in scleroderma: Opportunities for therapy? publication-title: Curr. Opin. Rheumatol. doi: 10.1097/BOR.0000000000000543 – volume: 9 start-page: 136 year: 2007 end-page: 143 ident: CR9 article-title: New developments in fibroblast and myofibroblast biology: Implications for fibrosis and scleroderma publication-title: Curr. Rheumatol. Rep. doi: 10.1007/s11926-007-0008-z – volume: 3 start-page: e2207 year: 2008 ident: CR28 article-title: A constitutional translocation t(1;17) (p36.2;q11.2) in a neuroblastoma patient disrupts the human NBPF1 and ACCN1 genes publication-title: PLoS ONE doi: 10.1371/journal.pone.0002207 – volume: 139 start-page: 871 year: 2009 end-page: 890 ident: CR16 article-title: Epithelial-mesenchymal transitions in development and disease publication-title: Cell doi: 10.1016/j.cell.2009.11.007 – volume: 6 start-page: 283 year: 2010 end-page: 294 ident: CR37 article-title: Role of growth factors in the pathogenesis of tissue fibrosis in systemic sclerosis publication-title: Curr. Rheumatol. Rev. doi: 10.2174/157339710793205611 – volume: 209 start-page: 77 year: 2019 end-page: 89 ident: CR13 article-title: Evolving insights into the cellular and molecular pathogenesis of fibrosis in systemic sclerosis publication-title: Transl. Res. doi: 10.1016/j.trsl.2019.02.010 – volume: 87 start-page: 858 year: 2007 end-page: 870 ident: CR15 article-title: The role of the fibrocytes, a bone marrow-derived mesenchymal progenitor, in reactive and reparative fibroses publication-title: Lab. lnvest. doi: 10.1038/labinvest.3700654 – volume: 68–69 start-page: 522 year: 2018 end-page: 532 ident: CR34 article-title: New developments on skin fibrosis—Essential signals emanating from the extracellular matrix for the control of myofibroblasts publication-title: Matrix Biol. doi: 10.1016/j.matbio.2018.01.025 – volume: 15 start-page: 202 year: 1988 end-page: 205 ident: CR42 article-title: Scleroderma (systemic sclerosis): Classification, subsets and pathogenesis publication-title: J. Rheumatol. – volume: 9 start-page: 2452 year: 2018 ident: CR11 article-title: Unraveling SSc pathophysiology; the myofibroblast publication-title: Front. Immunol. doi: 10.3389/fimmu.2018.02452 – volume: 2 start-page: 134 year: 2006 end-page: 144 ident: CR35 article-title: Mechanisms and consequences of fibrosis in systemic sclerosis publication-title: Nat. Clin. Pract. Rheumatol. doi: 10.1038/ncprheum0115 – volume: 79 start-page: 507 year: 2020 end-page: 517 ident: CR26 article-title: Long non-coding RNA HOTAIR drives EZH2-dependent myofibroblast activation in systemic sclerosis through miRNA 34a-dependent activation of NOTCH publication-title: Ann. Rheum. Dis. doi: 10.1136/annrheumdis-2019-216542 – volume: 54 start-page: 3655 year: 2006 end-page: 3660 ident: CR12 article-title: Myofibroblasts and hyalinized collagen as markers of skin disease in systemic sclerosis publication-title: Arthritis Rheum. doi: 10.1002/art.22186 – volume: 12 start-page: 1046 year: 2013 end-page: 1051 ident: CR32 article-title: Potential role of human-specific genes, human-specific microRNAs and human-specific non-coding regulatory RNAs in the pathogenesis of systemic sclerosis and Sjögren's syndrome publication-title: Autoimmun. Rev. doi: 10.1016/j.autrev.2013.04.004 – volume: 2013 start-page: 835948 year: 2013 ident: CR20 article-title: Role of endothelial to mesenchymal transition in the pathogenesis of the vascular alterations in systemic sclerosis publication-title: ISRN Rheumatol. doi: 10.1155/2013/835948 – volume: 76 start-page: 924 year: 2017 end-page: 934 ident: CR21 article-title: Endothelial-to-mesenchymal transition contributed to endothelial dysfunction and dermal fibrosis in systemic sclerosis publication-title: Ann. Rheum. Dis. doi: 10.1136/annrheumdis-2016-210229 – volume: 22 start-page: 2265 year: 2005 end-page: 2274 ident: CR27 article-title: A novel gene family NBPF: Intricate structure generated by gene duplications during primate evolution publication-title: Mol. Biol. Evol. doi: 10.1093/molbev/msi222 – volume: 10 start-page: 706 year: 2014 end-page: 719 ident: CR38 article-title: Transforming growth factor β-at the centre of systemic sclerosis publication-title: Nat. Rev. Rheumatol. doi: 10.1038/nrrheum.2014.137 – volume: 40 start-page: 1365 year: 2009 end-page: 1376 ident: CR17 article-title: Direct contribution of epithelium to organ fibrosis: Epithelial-mesenchymal transition publication-title: Hum. Pathol. doi: 10.1016/j.humpath.2009.02.020 – volume: 233 start-page: 98 year: 2018 end-page: 106 ident: CR39 article-title: TGFβ signaling and the control of myofibroblast differentiation: Implications for chronic inflammatory disorders publication-title: J. Cell. Physiol. doi: 10.1002/jcp.25879 – volume: 99 start-page: 1281 year: 2019 end-page: 1324 ident: CR23 article-title: Endothelial to mesenchymal transition: Role in physiology and in the pathogenesis of human disease publication-title: Physiol. Rev. doi: 10.1152/physrev.00021.2018 – volume: 91 start-page: 444 year: 2012 end-page: 454 ident: CR29 article-title: DUF1220-domain copy number implicated in human brain-size pathology and evolution publication-title: Am. J. Hum. Genet. doi: 10.1016/j.ajhg.2012.07.016 – volume: 69 start-page: 2024 year: 2010 end-page: 2033 ident: CR46 article-title: NFκB activation and stimulation of chemokine production in normal human macrophages by the gadolinium-based magnetic resonance contrast agent Omniscan: Possible role in the pathogenesis of nephrogenic systemic fibrosis publication-title: Ann. Rheum. Dis. doi: 10.1136/ard.2010.134858 – volume: 1 start-page: 15002 year: 2015 ident: CR2 article-title: Systemic sclerosis publication-title: Nat. Rev. Dis. Primers doi: 10.1038/nrdp.2015.2 – volume: 231 start-page: 273 year: 2013 end-page: 289 ident: CR24 article-title: Understanding the origin, activation and regulation of matrix-producing myofibroblasts for treatment of fibrotic disease publication-title: J. Pathol. doi: 10.1002/path.4253 – volume: 91 start-page: 444 year: 2012 ident: 99292_CR29 publication-title: Am. J. Hum. Genet. doi: 10.1016/j.ajhg.2012.07.016 – volume: 360 start-page: 1989 year: 2009 ident: 99292_CR1 publication-title: N. Engl. J. Med. doi: 10.1056/NEJMra0806188 – volume: 231 start-page: 273 year: 2013 ident: 99292_CR24 publication-title: J. Pathol. doi: 10.1002/path.4253 – volume: 68–69 start-page: 522 year: 2018 ident: 99292_CR34 publication-title: Matrix Biol. doi: 10.1016/j.matbio.2018.01.025 – volume: 69 start-page: 2024 year: 2010 ident: 99292_CR46 publication-title: Ann. Rheum. Dis. doi: 10.1136/ard.2010.134858 – volume: 237 start-page: 837 year: 1986 ident: 99292_CR43 publication-title: Biochem. J. doi: 10.1042/bj2370837 – volume: 87 start-page: 858 year: 2007 ident: 99292_CR15 publication-title: Lab. lnvest. doi: 10.1038/labinvest.3700654 – volume: 7 start-page: S157 year: 2020 ident: 99292_CR19 publication-title: Eur. J. Rheumatol. doi: 10.5152/eurjrheum.2019.19081 – volume: 9 start-page: 2452 year: 2018 ident: 99292_CR11 publication-title: Front. Immunol. doi: 10.3389/fimmu.2018.02452 – volume: 1 start-page: 226 year: 2009 ident: 99292_CR36 publication-title: Front. Biosci. (Sch. Ed.) doi: 10.2741/s22 – volume: 68 start-page: 210 year: 2016 ident: 99292_CR22 publication-title: Arthritis Rheumatol. doi: 10.1002/art.39421 – volume: 9 start-page: 136 year: 2007 ident: 99292_CR9 publication-title: Curr. Rheumatol. Rep. doi: 10.1007/s11926-007-0008-z – volume: 390 start-page: 1685 year: 2017 ident: 99292_CR3 publication-title: Lancet doi: 10.1016/S0140-6736(17)30933-9 – volume: 73 start-page: 1145 year: 2016 ident: 99292_CR8 publication-title: Cell. Mol. Life Sci. doi: 10.1007/s00018-015-2110-0 – volume: 365 start-page: 495 year: 2016 ident: 99292_CR18 publication-title: Cell Tissue Res. doi: 10.1007/s00441-016-2464-0 – volume: 1 start-page: 15002 year: 2015 ident: 99292_CR2 publication-title: Nat. Rev. Dis. Primers doi: 10.1038/nrdp.2015.2 – volume: 209 start-page: 77 year: 2019 ident: 99292_CR13 publication-title: Transl. Res. doi: 10.1016/j.trsl.2019.02.010 – volume: 54 start-page: 3655 year: 2006 ident: 99292_CR12 publication-title: Arthritis Rheum. doi: 10.1002/art.22186 – volume: 3 start-page: e2207 year: 2008 ident: 99292_CR28 publication-title: PLoS ONE doi: 10.1371/journal.pone.0002207 – volume: 45 start-page: 2479 year: 2013 ident: 99292_CR30 publication-title: Int. J. Biochem. Cell Biol. doi: 10.1016/j.biocel.2013.07.022 – volume: 58 start-page: 2854 year: 2008 ident: 99292_CR44 publication-title: Arthritis Rheum. doi: 10.1002/art.23791 – volume: 9 start-page: 4521 year: 2019 ident: 99292_CR40 publication-title: Sci. Rep. doi: 10.1038/s41598-019-41153-w – volume: 200 start-page: 500 year: 2003 ident: 99292_CR5 publication-title: J. Pathol. doi: 10.1002/path.1427 – volume: 30 start-page: 581 year: 2018 ident: 99292_CR10 publication-title: Curr. Opin. Rheumatol. doi: 10.1097/BOR.0000000000000543 – volume: 2013 start-page: 835948 year: 2013 ident: 99292_CR20 publication-title: ISRN Rheumatol. doi: 10.1155/2013/835948 – volume: 2 start-page: 134 year: 2006 ident: 99292_CR35 publication-title: Nat. Clin. Pract. Rheumatol. doi: 10.1038/ncprheum0115 – volume: 40 start-page: 1365 year: 2009 ident: 99292_CR17 publication-title: Hum. Pathol. doi: 10.1016/j.humpath.2009.02.020 – volume: 78 start-page: 1379 year: 2019 ident: 99292_CR25 publication-title: Ann. Rheum. Dis. doi: 10.1136/annrheumdis-2018-214865 – volume: 1 start-page: 71 year: 1994 ident: 99292_CR14 publication-title: Mol. Med. doi: 10.1007/BF03403533 – volume: 6 start-page: 283 year: 2010 ident: 99292_CR37 publication-title: Curr. Rheumatol. Rev. doi: 10.2174/157339710793205611 – volume: 139 start-page: 871 year: 2009 ident: 99292_CR16 publication-title: Cell doi: 10.1016/j.cell.2009.11.007 – volume: 233 start-page: 98 year: 2018 ident: 99292_CR39 publication-title: J. Cell. Physiol. doi: 10.1002/jcp.25879 – volume: 12 start-page: 1046 year: 2013 ident: 99292_CR32 publication-title: Autoimmun. Rev. doi: 10.1016/j.autrev.2013.04.004 – volume: 79 start-page: 507 year: 2020 ident: 99292_CR26 publication-title: Ann. Rheum. Dis. doi: 10.1136/annrheumdis-2019-216542 – volume: 99 start-page: 1281 year: 2019 ident: 99292_CR23 publication-title: Physiol. Rev. doi: 10.1152/physrev.00021.2018 – volume: 15 start-page: 202 year: 1988 ident: 99292_CR42 publication-title: J. Rheumatol. – volume: 379 start-page: 119 year: 2019 ident: 99292_CR33 publication-title: Exp. Cell Res. doi: 10.1016/j.yexcr.2019.03.027 – volume: 72 start-page: 1747 year: 2013 ident: 99292_CR41 publication-title: Ann. Rheum. Dis. doi: 10.1136/annrheumdis-2013-204424 – volume: 17 start-page: 333 year: 2003 ident: 99292_CR45 publication-title: J. Endourol. doi: 10.1089/089277903322145530 – volume: 117 start-page: 557 year: 2007 ident: 99292_CR4 publication-title: J. Clin. Invest. doi: 10.1172/JCI31139 – volume: 10 start-page: 706 year: 2014 ident: 99292_CR38 publication-title: Nat. Rev. Rheumatol. doi: 10.1038/nrrheum.2014.137 – volume: 5 start-page: 99 year: 2011 ident: 99292_CR31 publication-title: Hum. Genom. doi: 10.1186/1479-7364-5-2-99 – volume: 76 start-page: 924 year: 2017 ident: 99292_CR21 publication-title: Ann. Rheum. Dis. doi: 10.1136/annrheumdis-2016-210229 – volume: 3 start-page: 349 year: 2002 ident: 99292_CR6 publication-title: Nat. Rev. Mol. Cell. Biol. doi: 10.1038/nrm809 – volume: 180 start-page: 1340 year: 2012 ident: 99292_CR7 publication-title: Am. J. Pathol. doi: 10.1016/j.ajpath.2012.02.004 – volume: 22 start-page: 2265 year: 2005 ident: 99292_CR27 publication-title: Mol. Biol. Evol. doi: 10.1093/molbev/msi222
SSID	ssj0000529419
Score	2.36215
Snippet	Myofibroblasts are the key effector cells responsible for the exaggerated tissue fibrosis in Systemic Sclerosis (SSc). Despite their importance to SSc... Abstract Myofibroblasts are the key effector cells responsible for the exaggerated tissue fibrosis in Systemic Sclerosis (SSc). Despite their importance to SSc...
SourceID	doaj pubmedcentral proquest pubmed crossref springer
SourceType	Open Website Open Access Repository Aggregation Database Index Database Enrichment Source Publisher
StartPage	20435
SubjectTerms	631/1647/2017/2003 631/1647/2017/2079 692/699/1670/122/1801 Actin Adult Blotting, Western Case-Control Studies Cell lineage DNA microarrays Effector cells Female Fibroblasts Fibrosis Gene expression Gene Expression Profiling Genes, Neoplasm Genomes Humanities and Social Sciences Humans Immunohistochemistry Laser Capture Microdissection Male multidisciplinary Myofibroblasts - metabolism Neoplasm Proteins - genetics Neuroblastoma Pathogenesis Real-Time Polymerase Chain Reaction Science Science (multidisciplinary) Scleroderma Scleroderma, Systemic - genetics Scleroderma, Systemic - metabolism Skin - metabolism Smooth muscle Systemic sclerosis Therapeutic targets Transcriptomes Transforming Growth Factor beta - metabolism Western blotting
SummonAdditionalLinks	– databaseName: Science Database dbid: M2P link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Lj9MwEB7BAtJeeMMGFmQkbhBtk7ixfUIsouIAVQ8g7c1yHIetRJOl7iL6H_jRzDhOlvLYC7fIcSeeesb-PDOeAXhuSysQqTapKpRJeSFcquS0SrlFbFBKWVcuXBR-L-ZzeXKiFtHg5mNY5bAmhoW67izZyI_yqQzJ7wr-6uxrSlWjyLsaS2hchWuIbDIK6fqQL0YbC3mxeKbiXZlJIY887ld0p4ziEhAY5Ol2Zz8Kafv_hjX_DJn8zW8atqPZrf9l5DbcjECUve4l5w5cce1duNGXptzegx99MQCG8uWY-x7DZVtmYhIT1jWszwK9tMwjBeQOW1dbFNaKitQYv_GsdivCn5SOwjPDVhQLVLNlS1DVO3xgiD9_JY9UhxBHNj9ezML3_X34NHv78c27NFZuSC0iwE2aGzyc2qw0Urgpr3iFpxpraz5F9FDy0tQWcYhssHNFFpWmzLO65sKIsrFlgyDpAey1XesOgOHyKys74binKC4LFHwyY1uj8JxjRJEnkA3zp21Ma07VNb7o4F4vpO7nXOOc6zDnepvAi_E3Z31Sj0t7H5NYjD0pIXdo6NafddRvPalxXxcGIYEqObKNzDU56oc02Ii8JXA4SIOOq4TXF6KQwLPxNeo3OW1M67rz0CeXSDVTCTzsZXAcScERXyNCTEDsSOfOUHfftMvTkENcBv8o0nw5yPHFsP79Vzy6nIvHsJ-TalHADz-Evc363D2B6_bbZunXT4Nu_gSmFUSi priority: 102 providerName: ProQuest
Title	Global gene expression analysis of systemic sclerosis myofibroblasts demonstrates a marked increase in the expression of multiple NBPF genes
URI	https://link.springer.com/article/10.1038/s41598-021-99292-y https://www.ncbi.nlm.nih.gov/pubmed/34650102 https://www.proquest.com/docview/2581965934 https://www.proquest.com/docview/2582813919 https://pubmed.ncbi.nlm.nih.gov/PMC8516909 https://doaj.org/article/0d2997a413964a878fcf2bec8a7a4dd4
Volume	11
WOSCitedRecordID	wos000707419500083&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
journalDatabaseRights	– providerCode: PRVAON databaseName: DOAJ Directory of Open Access Journals customDbUrl: eissn: 2045-2322 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000529419 issn: 2045-2322 databaseCode: DOA dateStart: 20110101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVHPJ databaseName: ROAD: Directory of Open Access Scholarly Resources customDbUrl: eissn: 2045-2322 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000529419 issn: 2045-2322 databaseCode: M~E dateStart: 20110101 isFulltext: true titleUrlDefault: https://road.issn.org providerName: ISSN International Centre – providerCode: PRVPQU databaseName: Biological Science Database customDbUrl: eissn: 2045-2322 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000529419 issn: 2045-2322 databaseCode: M7P dateStart: 20110101 isFulltext: true titleUrlDefault: http://search.proquest.com/biologicalscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: Health & Medical Collection customDbUrl: eissn: 2045-2322 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000529419 issn: 2045-2322 databaseCode: 7X7 dateStart: 20110101 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central (NC Live) customDbUrl: eissn: 2045-2322 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000529419 issn: 2045-2322 databaseCode: BENPR dateStart: 20110101 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: Publicly Available Content Database customDbUrl: eissn: 2045-2322 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000529419 issn: 2045-2322 databaseCode: PIMPY dateStart: 20110101 isFulltext: true titleUrlDefault: http://search.proquest.com/publiccontent providerName: ProQuest – providerCode: PRVPQU databaseName: Science Database customDbUrl: eissn: 2045-2322 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000529419 issn: 2045-2322 databaseCode: M2P dateStart: 20110101 isFulltext: true titleUrlDefault: https://search.proquest.com/sciencejournals providerName: ProQuest
link	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Nj9MwELVgF6S9IL4JLJWRuEG0jePG9pGirUBiqwiBVE6W4zjaSjRFm-6K_gd-NM92Wlo-L1ysyHYm1szYfo7Hz4Q8t4UVQKpNqnJlUp4Llyo5qlJugQ0KKevKhYPC78R0KmczVe5c9eVjwiI9cFTcybDGgCkMxlpVcCOFbGzD8GFpkFnXgQl0KNTOYiqyejPFM9Wfkhnm8qTDTOVPk_mIBEAClq73ZqJA2P87lPlrsORPO6ZhIprcJrd6BElfxZbfIddce5fcjHdKru-Rb5HFn8IxHHVf-zjXlpqefYQuGxrpm-eWdpCAxiF3sYaXVf52GdOtOlq7hQeOnkeio4YufBBPTeetx5idwwMFcNwVD6mb2EQ6HZeT8P3uPvk4Of3w-k3aX7mQWkC3VcoMVpU2K6BoN-IVr7AcsbbmI0z7BS9MbQEgYAKU-V8hTcEy2EAYUTS2aIBuHpCDdtm6R4Ri3JSVHXJMBorLHB7r_z9bo7BAMSJnCck26te25yP312J81mFfPJc6mkzDZDqYTK8T8mL7zpfIxvHX2mNv1W1Nz6QdMuBfuvcv_S__Ssjxxid03707zUYyMDHmKH62LUbH9LstpnXLy1CHSUjNVEIeRhfatiTnAMaAdgkRe86119T9knZ-Hsi_ZdjYhMyXGzf80aw_q-Lx_1DFE3LEfP_x8Tz8mBysLi7dU3LDXq3m3cWAXBczEVI5IIfj02n5fhA6JdIzVvpUID0s356Vn74DVnE-Cw
linkProvider	Directory of Open Access Journals
linkToHtml	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9QwEB6VAioX3o9AASPBCaJuHG_iHBCiwKpVl9UeitSb6zgOXYlNymYL5D_wW_iNzDiPsjx664Fb5Hgntnce39jjGYCnJjIxItXcT8JE-yKMrZ_IYeoLg9ggkjJLrbsoPI4nE3lwkEzX4Ed3F4bCKjud6BR1VhraI9_iQ-mS34Xi1fFnn6pG0elqV0KjYYs9W39Fl616ufsW_99nnI_e7b_Z8duqAr5BdLL0uUbHyQSRlrEdilSkiLiNycQQLVskIp0ZtJEyx84peft5xIMsE7GOo9xEORpwpHsBLgrKLEahgnza7-nQqZkIkvZuziCUWxXaR7rDRnEQCES4X6_YP1cm4G_Y9s8Qzd_OaZ35G1373xbuOlxtgTZ73UjGDVizxU243JTerG_B96bYAUP5scx-a8OBC6bbJC2szFmT5XpmWIUUcDWxdV6jMKZUhEdXy4pldk74mtJtVEyzOcU6ZWxWEBSvLD4wxNe_kkeqXQgnm2xPR-771W34cC5LcQfWi7Kw94CheZGpGQi0mYmQIQo2bdMbnaAfp-OQexB0_KJMm7adqod8Ui58IJSq4TGFPKYcj6nag-f9b46bpCVn9t4mNux7UsJx11AuPqpWf6lBhrgl1gh5kkjgtHFyOUf5lxobcW4ebHbcp1otWKlT1vPgSf8a9RcdSunClieuD5dINUg8uNvwfD-SUKD_gAjYg3hFGlaGuvqmmB25HOnSnf8izRed3JwO699Lcf_sWTyGjZ3992M13p3sPYArnMSagpvEJqwvFyf2IVwyX5azavHI6QUGh-ctTz8BPUugPQ
linkToPdf	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lj9MwEB4tXUBceD8CCxgJThC1ddzEOSDEslSsdql6AGk5GcdxoBJNl6YL9D_wi_h1fHaSLuWxtz1wixx3Yrvz-MYezxA9NLFJgFSLMI1SHYoosWEqB1koDLBBLGWeWX9ReD8ZjeTBQTreoB_tXRgXVtnqRK-o85lxe-RdPpA--V0kukUTFjHeGT47_By6ClLupLUtp1GzyJ5dfoX7Vj3d3cF__Yjz4cs3L16FTYWB0ACpLEKu4USZfqxlYgciExnQtzG5GMDKxSLWuYG9lAU6Z87zL2Lez3OR6CQuTFzAmIPuGdoEJBe8Q5vj3dfjd6sdHneGJvppc1OnF8luBWvpbrS5qAjAEh4u16yhLxrwN6T7Z8Dmb6e23hgOL_3Py3iZLjYQnD2vZeYKbdjyKp2ri3Iur9H3ugwCg2RZZr81gcIl0036FjYrWJ3_emJYBQpYWbROlxDTzJXn0dWiYrmdOuTtEnFUTLOpi4LK2aR0IL2yeGBA3r-SB9U2uJONtsdD__3qOr09laW4QZ1yVtpbxGB4ZGZ6AtY0FTKCyLsNfKNTeHg6iXhA_ZZ3lGkSuru6Ip-UDyyIpKr5TYHflOc3tQzo8eo3h3U6kxN7bzuWXPV0qch9w2z-QTWaTfVyIJpEAwylscC0MbmCQzNIjUbMLaCtlhNVox8rdcyGAT1YvYZmc8dVurSzI9-HS1DtpwHdrPl_NZJIwLMANg4oWZOMtaGuvyknH332dOlPhkHzSStDx8P691LcPnkW9-k8xEjt74727tAF7iTcRT2JLeos5kf2Lp01XxaTan6vURKM3p-2QP0ElFGqhg
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Global+gene+expression+analysis+of+systemic+sclerosis+myofibroblasts+demonstrates+a+marked+increase+in+the+expression+of+multiple+NBPF+genes&rft.jtitle=Scientific+reports&rft.au=Abignano%2C+Giuseppina&rft.au=Hermes%2C+Heidi&rft.au=Piera-Velazquez%2C+Sonsoles&rft.au=Addya%2C+Sankar&rft.date=2021-10-14&rft.eissn=2045-2322&rft.volume=11&rft.issue=1&rft.spage=20435&rft_id=info:doi/10.1038%2Fs41598-021-99292-y&rft_id=info%3Apmid%2F34650102&rft.externalDocID=34650102
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2045-2322&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2045-2322&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2045-2322&client=summon