Comprehensive mapping of SARS-CoV-2 interactions in vivo reveals functional virus-host interactions

SARS-CoV-2 is a major threat to global health. Here, we investigate the RNA structure and RNA-RNA interactions of wildtype (WT) and a mutant (Δ382) SARS-CoV-2 in cells using Illumina and Nanopore platforms. We identify twelve potentially functional structural elements within the SARS-CoV-2 genome, o...

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Bibliographic Details
Published in:	Nature communications Vol. 12; no. 1; pp. 5113 - 15
Main Authors:	Yang, Siwy Ling, DeFalco, Louis, Anderson, Danielle E., Zhang, Yu, Aw, Jong Ghut Ashley, Lim, Su Ying, Lim, Xin Ni, Tan, Kiat Yee, Zhang, Tong, Chawla, Tanu, Su, Yan, Lezhava, Alexander, Merits, Andres, Wang, Lin-Fa, Huber, Roland G., Wan, Yue
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 25.08.2021 Nature Publishing Group Nature Portfolio
Subjects:	45 45/43 49/90 631/326/596/2557 631/326/596/4130 631/61/212/177 COVID-19 COVID-19 - genetics COVID-19 - metabolism COVID-19 - physiopathology COVID-19 - virology DNA Methylation Gene mapping Gene sequencing Genome, Viral Genomes Global health Host Microbial Interactions Humanities and Social Sciences Humans Methylation Mitochondria multidisciplinary Nucleic Acid Conformation Nucleoli Pathogenicity Pathogens Protein structure Public health Ribonucleic acid RNA RNA - chemistry RNA - genetics RNA - metabolism RNA viruses RNA, Viral - chemistry RNA, Viral - genetics RNA, Viral - metabolism SARS-CoV-2 - chemistry SARS-CoV-2 - genetics SARS-CoV-2 - physiology Science Science (multidisciplinary) Secondary structure Severe acute respiratory syndrome coronavirus 2 Structural members Structure-function relationships Viral diseases Viruses
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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