Association of mannose-binding lectin 2 gene polymorphisms with Guillain-Barré syndrome

Complement activation plays a critical role in the pathogenesis of Guillain-Barré syndrome (GBS), a debilitating immune-mediated neuropathy. Mannose-binding lectin (MBL) is a complement activation factor of lectin pathway which as genetic host factor may influence the susceptibility or severity of G...

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Vydáno v:Scientific reports Ročník 12; číslo 1; s. 5791 - 11
Hlavní autoři: Jahan, Israt, Hayat, Shoma, Khalid, Mir M., Ahammad, Rijwan U., Asad, Asaduzzaman, Islam, Badrul, Mohammad, Quazi D., Jacobs, Bart C., Islam, Zhahirul
Médium: Journal Article
Jazyk:angličtina
Vydáno: London Nature Publishing Group UK 06.04.2022
Nature Publishing Group
Nature Portfolio
Témata:
631/337
692/420
692/53
692/617
Adolescent
Adult
Complement Activation
Exons
Gene polymorphism
Genetic Predisposition to Disease
Genotype
Guillain-Barre syndrome
Guillain-Barre Syndrome - genetics
Haplotypes
Heterozygosity
Humanities and Social Sciences
Humans
Lectins
Male
Mannose
Mannose-binding lectin
Mannose-Binding Lectin - genetics
multidisciplinary
Neuropathy
Patients
Polymorphism, Genetic
Science
Science (multidisciplinary)
Young Adult
ISSN:2045-2322, 2045-2322
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Shrnutí:Complement activation plays a critical role in the pathogenesis of Guillain-Barré syndrome (GBS), a debilitating immune-mediated neuropathy. Mannose-binding lectin (MBL) is a complement activation factor of lectin pathway which as genetic host factor may influence the susceptibility or severity of GBS. We investigated the frequency of MBL2 promoter (− 550H/L and − 221X/Y) and functional region (exon 1 A/O) polymorphisms and their association with disease susceptibility, clinical features and serum MBL among GBS patients ( n  = 300) and healthy controls ( n  = 300) in Bangladesh. The median patient age was 30 years (IQR: 18–42; males, 68%). MBL2 polymorphisms were not significantly associated with GBS susceptibility compared to healthy controls. HL heterozygosity in GBS patients was significantly associated with mild functional disability at enrolment ( P  = 0.0145, OR, 95% CI 2.1, 1.17–3.82). The HY, YA, HA and HYA heterozygous haplotypes were more common among mildly affected ( P  = 0.0067, P  = 0.0086, P  = 0.0075, P  = 0.0032, respectively) than severely affected patients with GBS. Reduced serum MBL was significantly associated with the LL, OO and no HYA variants and GBS disease severity. No significant association was observed between MBL2 polymorphisms and electrophysiological variants, recent Campylobacter jejuni infection or anti-ganglioside (GM1) antibody responses in GBS. In conclusion, MBL2 gene polymorphisms are related to reduced serum MBL and associated with the severity of GBS.
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ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-022-09621-y