Genetic evidence for a normal-weight "metabolically obese" phenotype linking insulin resistance, hypertension, coronary artery disease, and type 2 diabetes

The mechanisms that predispose to hypertension, coronary artery disease (CAD), and type 2 diabetes (T2D) in individuals of normal weight are poorly understood. In contrast, in monogenic primary lipodystrophy-a reduction in subcutaneous adipose tissue-it is clear that it is adipose dysfunction that c...

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Bibliographic Details

Published in:	Diabetes (New York, N.Y.) Vol. 63; no. 12; p. 4369
Main Authors:	Yaghootkar, Hanieh, Scott, Robert A, White, Charles C, Zhang, Weihua, Speliotes, Elizabeth, Munroe, Patricia B, Ehret, Georg B, Bis, Joshua C, Fox, Caroline S, Walker, Mark, Borecki, Ingrid B, Knowles, Joshua W, Yerges-Armstrong, Laura, Ohlsson, Claes, Perry, John R B, Chambers, John C, Kooner, Jaspal S, Franceschini, Nora, Langenberg, Claudia, Hivert, Marie-France, Dastani, Zari, Richards, J Brent, Semple, Robert K, Frayling, Timothy M
Format:	Journal Article
Language:	English
Published:	United States 01.12.2014
Subjects:	Body Mass Index Coronary Artery Disease - genetics Diabetes Mellitus, Type 2 - genetics Genetic Predisposition to Disease Humans Hypertension - genetics Insulin Resistance - genetics Intra-Abdominal Fat Lipodystrophy - genetics Metabolic Syndrome - genetics Obesity - genetics Odds Ratio Phenotype Subcutaneous Fat
ISSN:	1939-327X, 1939-327X
Online Access:	Get more information
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