Melatonin in Neurodevelopmental Disorders: A Critical Literature Review

The article presents a review of the relationships between melatonin and neurodevelopmental disorders. First, the antioxidant properties of melatonin and its physiological effects are considered to understand better the role of melatonin in typical and atypical neurodevelopment. Then, several neurod...

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Bibliographic Details
Published in:Antioxidants Vol. 12; no. 11; p. 2017
Main Authors: Feybesse, Cyrille, Chokron, Sylvie, Tordjman, Sylvie
Format: Journal Article
Language:English
Published: Basel MDPI AG 01.11.2023
MDPI
Series:Antioxidants
Subjects:
adulthood
Aging
Angelman's syndrome
Antioxidants
Autism
Biological clocks
Bipolar disorder
brain development
Circadian rhythm
Circadian rhythms
Disease
Enzymes
Fetuses
Free radicals
infancy
Life Sciences
Literature reviews
Melatonin
Mental disorders
Neurodevelopment
Neurodevelopmental disorders
Oxidative stress
pathophysiology
Pervasive developmental disorders
Physiological aspects
Physiology
Pregnancy
Schizophrenia
sclerosis
Serotonin
Sleep
Sleep and wakefulness
sleep disturbance
sleep–wake rhythms
Tuberous sclerosis
France
brain development
sleep disturbance
sleep-wake rhythms
schizophrenia
circadian rhythms
melatonin
neurodevelopmental disorders
autism
ISSN:2076-3921, 2076-3921
Online Access:Get full text
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Summary:The article presents a review of the relationships between melatonin and neurodevelopmental disorders. First, the antioxidant properties of melatonin and its physiological effects are considered to understand better the role of melatonin in typical and atypical neurodevelopment. Then, several neurodevelopmental disorders occurring during infancy, such as autism spectrum disorder or neurogenetic disorders associated with autism (including Smith–Magenis syndrome, Angelman syndrome, Rett’s syndrome, Tuberous sclerosis, or Williams–Beuren syndrome) and neurodevelopmental disorders occurring later in adulthood like bipolar disorder and schizophrenia, are discussed with regard to impaired melatonin production and circadian rhythms, in particular, sleep–wake rhythms. This article addresses the issue of overlapping symptoms that are commonly observed within these different mental conditions and debates the role of abnormal melatonin production and altered circadian rhythms in the pathophysiology and behavioral expression of these neurodevelopmental disorders.
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ISSN:2076-3921
2076-3921
DOI:10.3390/antiox12112017