Corneal confocal microscopy demonstrates axonal loss in different courses of multiple sclerosis

Axonal loss is the main determinant of disease progression in multiple sclerosis (MS). This study aimed to assess the utility of corneal confocal microscopy (CCM) in detecting corneal axonal loss in different courses of MS. The results were confirmed by two independent segmentation methods. 72 subje...

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Vydáno v:	Scientific reports Ročník 11; číslo 1; s. 21688 - 9
Hlavní autoři:	Petropoulos, Ioannis N., Fitzgerald, Kathryn C., Oakley, Jonathan, Ponirakis, Georgios, Khan, Adnan, Gad, Hoda, George, Pooja, Deleu, Dirk, Canibano, Beatriz G., Akhtar, Naveed, Shuaib, Ashfaq, Own, Ahmed, Malik, Taimur, Russakoff, Daniel B., Mankowski, Joseph L., Misra, Stuti L., McGhee, Charles N. J., Calabresi, Peter, Saidha, Shiv, Kamran, Saadat, Malik, Rayaz A.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	London Nature Publishing Group UK 04.11.2021 Nature Publishing Group Nature Portfolio
Témata:	692/53 692/53/2421 692/617 Adult Algorithms Autoimmune diseases Axons - physiology Biomarkers Confocal microscopy Cornea Cornea - diagnostic imaging Cornea - innervation Cornea - metabolism Disease Progression Female Fibers Humanities and Social Sciences Humans Male Microscopy Microscopy, Confocal - methods Middle Aged multidisciplinary Multiple sclerosis Multiple Sclerosis - metabolism Multiple Sclerosis - physiopathology Nerve Fibers Reproducibility of Results Science Science (multidisciplinary) Segmentation
ISSN:	2045-2322, 2045-2322
On-line přístup:	Získat plný text
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