Corneal confocal microscopy demonstrates axonal loss in different courses of multiple sclerosis

Axonal loss is the main determinant of disease progression in multiple sclerosis (MS). This study aimed to assess the utility of corneal confocal microscopy (CCM) in detecting corneal axonal loss in different courses of MS. The results were confirmed by two independent segmentation methods. 72 subje...

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Vydané v:Scientific reports Ročník 11; číslo 1; s. 21688 - 9
Hlavní autori: Petropoulos, Ioannis N., Fitzgerald, Kathryn C., Oakley, Jonathan, Ponirakis, Georgios, Khan, Adnan, Gad, Hoda, George, Pooja, Deleu, Dirk, Canibano, Beatriz G., Akhtar, Naveed, Shuaib, Ashfaq, Own, Ahmed, Malik, Taimur, Russakoff, Daniel B., Mankowski, Joseph L., Misra, Stuti L., McGhee, Charles N. J., Calabresi, Peter, Saidha, Shiv, Kamran, Saadat, Malik, Rayaz A.
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: London Nature Publishing Group UK 04.11.2021
Nature Publishing Group
Nature Portfolio
Predmet:
692/53
692/53/2421
692/617
Adult
Algorithms
Autoimmune diseases
Axons - physiology
Biomarkers
Confocal microscopy
Cornea
Cornea - diagnostic imaging
Cornea - innervation
Cornea - metabolism
Disease Progression
Female
Fibers
Humanities and Social Sciences
Humans
Male
Microscopy
Microscopy, Confocal - methods
Middle Aged
multidisciplinary
Multiple sclerosis
Multiple Sclerosis - metabolism
Multiple Sclerosis - physiopathology
Nerve Fibers
Reproducibility of Results
Science
Science (multidisciplinary)
Segmentation
ISSN:2045-2322, 2045-2322
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Shrnutí:Axonal loss is the main determinant of disease progression in multiple sclerosis (MS). This study aimed to assess the utility of corneal confocal microscopy (CCM) in detecting corneal axonal loss in different courses of MS. The results were confirmed by two independent segmentation methods. 72 subjects (144 eyes) [(clinically isolated syndrome (n = 9); relapsing–remitting MS (n = 20); secondary-progressive MS (n = 22); and age-matched, healthy controls (n = 21)] underwent CCM and assessment of their disability status. Two independent algorithms (ACCMetrics; and Voxeleron deepNerve) were used to quantify corneal nerve fiber density (CNFD) (ACCMetrics only), corneal nerve fiber length (CNFL) and corneal nerve fractal dimension (CNFrD). Data are expressed as mean ± standard deviation with 95% confidence interval (CI). Compared to controls, patients with MS had significantly lower CNFD (34.76 ± 5.57 vs. 19.85 ± 6.75 fibers/mm 2 , 95% CI − 18.24 to − 11.59, P  < .0001), CNFL [for ACCMetrics: 19.75 ± 2.39 vs. 12.40 ± 3.30 mm/mm 2 , 95% CI − 8.94 to − 5.77, P  < .0001; for deepNerve: 21.98 ± 2.76 vs. 14.40 ± 4.17 mm/mm 2 , 95% CI − 9.55 to − 5.6, P  < .0001] and CNFrD [for ACCMetrics: 1.52 ± 0.02 vs. 1.45 ± 0.04, 95% CI − 0.09 to − 0.05, P  < .0001; for deepNerve: 1.29 ± 0.03 vs. 1.19 ± 0.07, 95% − 0.13 to − 0.07, P  < .0001]. Corneal nerve parameters were comparably reduced in different courses of MS. There was excellent reproducibility between the algorithms. Significant corneal axonal loss is detected in different courses of MS including patients with clinically isolated syndrome.
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ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-021-01226-1