Metagenomic Shotgun Sequencing and Unbiased Metabolomic Profiling Identify Specific Human Gut Microbiota and Metabolites Associated with Immune Checkpoint Therapy Efficacy in Melanoma Patients

This is the first prospective study of the effects of human gut microbiota and metabolites on immune checkpoint inhibitor (ICT) response in metastatic melanoma patients. Whereas many melanoma patients exhibit profound response to ICT, there are fewer options for patients failing ICT—particularly wit...

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Bibliographic Details
Published in:	Neoplasia (New York, N.Y.) Vol. 19; no. 10; pp. 848 - 855
Main Authors:	Frankel, Arthur E., Coughlin, Laura A., Kim, Jiwoong, Froehlich, Thomas W., Xie, Yang, Frenkel, Eugene P., Koh, Andrew Y.
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01.10.2017 Elsevier Limited Elsevier
Subjects:	Adult Aged Aged, 80 and over Antineoplastic Agents, Immunological - pharmacology Antineoplastic Agents, Immunological - therapeutic use Bacteroides Biomarkers, Tumor Chromatography, High Pressure Liquid Cluster Analysis Female Gastrointestinal Microbiome High-Throughput Nucleotide Sequencing Humans Immune checkpoint inhibitors Intestinal microflora Male Melanoma Melanoma - drug therapy Melanoma - etiology Melanoma - metabolism Melanoma - pathology Metabolites Metabolomics Metabolomics - methods Metagenome Metagenomics - methods Metastases Metastasis Microbiomes Microbiota Middle Aged Molecular Targeted Therapy Monoclonal antibodies Neoplasm Metastasis Neoplasm Staging Prognosis Solid tumors Studies Tandem Mass Spectrometry Treatment Outcome
ISSN:	1476-5586, 1522-8002, 1476-5586, 1522-8002
Online Access:	Get full text
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