The genetics of obesity: from discovery to biology

The prevalence of obesity has tripled over the past four decades, imposing an enormous burden on people's health. Polygenic (or common) obesity and rare, severe, early-onset monogenic obesity are often polarized as distinct diseases. However, gene discovery studies for both forms of obesity sho...

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Vydáno v:	Nature reviews. Genetics Ročník 23; číslo 2; s. 120 - 133
Hlavní autoři:	Loos, Ruth J F, Yeo, Giles S H
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	England Nature Publishing Group 01.02.2022
Témata:	Age Animals Body weight Eating - genetics Gene-Environment Interaction Genetic Predisposition to Disease - genetics Genetic Variation Genome, Human - genetics Genome-wide association studies Genome-Wide Association Study - methods Genomes Humans Multifactorial Inheritance - genetics Obesity Obesity - genetics Overweight - genetics Whole Genome Sequencing - methods
ISSN:	1471-0056, 1471-0064, 1471-0064
On-line přístup:	Získat plný text
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Shrnutí:	The prevalence of obesity has tripled over the past four decades, imposing an enormous burden on people's health. Polygenic (or common) obesity and rare, severe, early-onset monogenic obesity are often polarized as distinct diseases. However, gene discovery studies for both forms of obesity show that they have shared genetic and biological underpinnings, pointing to a key role for the brain in the control of body weight. Genome-wide association studies (GWAS) with increasing sample sizes and advances in sequencing technology are the main drivers behind a recent flurry of new discoveries. However, it is the post-GWAS, cross-disciplinary collaborations, which combine new omics technologies and analytical approaches, that have started to facilitate translation of genetic loci into meaningful biology and new avenues for treatment.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Review-3 content type line 23
ISSN:	1471-0056 1471-0064 1471-0064
DOI:	10.1038/s41576-021-00414-z