The effect of endometriosis on the antimüllerian hormone level in the infertile population

Purpose To determine whether the presence of endometriosis in infertile women without prior ovarian surgery influences markers of ovarian reserve, AMH and FSH. Methods A retrospective cohort study included three groups of women who presented for IVF treatment at our tertiary care center from 04/27/2...

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Published in:Journal of assisted reproduction and genetics Vol. 36; no. 6; pp. 1179 - 1184
Main Authors: Romanski, Phillip A., Brady, Paula C., Farland, Leslie V., Thomas, Ann M., Hornstein, Mark D.
Format: Journal Article
Language:English
Published: New York Springer US 01.06.2019
Springer Nature B.V
Subjects:
Adult
Anti-Mullerian Hormone - blood
Endometriosis
Endometriosis - blood
Endometriosis - physiopathology
Estradiol - blood
Female
Follicle Stimulating Hormone - blood
Follicle-stimulating hormone
Gynecology
Human Genetics
Humans
Infertility
Infertility, Female - blood
Infertility, Female - physiopathology
Medicine
Medicine & Public Health
Ovarian Reserve - genetics
Ovary - growth & development
Ovary - pathology
Patients
Pregnancy
Reproductive Medicine
Reproductive Physiology and Disease
Reproductive Techniques, Assisted
Surgery
Antimüllerian hormone
Endometriosis
AMH
Infertility
Ovarian reserve
ISSN:1058-0468, 1573-7330, 1573-7330
Online Access:Get full text
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Summary:Purpose To determine whether the presence of endometriosis in infertile women without prior ovarian surgery influences markers of ovarian reserve, AMH and FSH. Methods A retrospective cohort study included three groups of women who presented for IVF treatment at our tertiary care center from 04/27/2015 to 05/31/2017: women with endometriosis and prior ovarian surgery (EnSx), women with endometriosis without prior ovarian surgery (En), and women with a primary diagnosis of male factor infertility (MF; reference group). Results There were 671 patients that met inclusion criteria (78 EnSx, 60 En, and 533 MF). Compared to the MF group (3.6 ± 3.0), a lower mean AMH level (ng/mL) was observed in the EnSx group (2.5 ± 2.5; aβ − 1.21; 95% CI [− 1.79, −0.62]) and in the En group (2.5 ± 2.2; aβ − 1.11; 95% CI [− 1.68, − 0.54]). Both endometriosis groups had a statistically significantly higher proportion of patients with an AMH < 1 (EnSx, 24.4%; OR, 2.39 [95% CI, 1.31, 4.36]; En, 28.3%; OR, 2.67 [95% CI, 1.41, 5.08]) compared to the MF group (13.9%). The mean baseline FSH level (lU/L) was statistically significantly higher in both endometriosis groups (EnSx, 8.6 ± 4.3; β , 1.37 [95% CI, 0.39, 2.34]; En, 8.4 ± 3.7; β , 0.96 [95% CI, 0.04, 1.87]) compared to the MF group (7.3 ± 2.2). Conclusions Among infertility patients with endometriosis, with and without a history of ovarian surgery, ovarian reserve markers were worse (lower AMH and higher FSH) and a higher proportion had decreased ovarian reserve as measured by AMH compared to women with MF.
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ISSN:1058-0468
1573-7330
1573-7330
DOI:10.1007/s10815-019-01450-9