A population-based matched cohort study of early pregnancy outcomes following COVID-19 vaccination and SARS-CoV-2 infection

Data on the safety of COVID-19 vaccines in early pregnancy are limited. We conducted a national, population-based, matched cohort study assessing associations between COVID-19 vaccination and miscarriage prior to 20 weeks gestation and, separately, ectopic pregnancy. We identified women in Scotland...

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Vydáno v:Nature communications Ročník 13; číslo 1; s. 6124 - 10
Hlavní autoři: Calvert, Clara, Carruthers, Jade, Denny, Cheryl, Donaghy, Jack, Hillman, Sam, Hopcroft, Lisa E. M., Hopkins, Leanne, Goulding, Anna, Lindsay, Laura, McLaughlin, Terry, Moore, Emily, Pan, Jiafeng, Taylor, Bob, Almaghrabi, Fatima, Auyeung, Bonnie, Bhaskaran, Krishnan, Gibbons, Cheryl L., Katikireddi, Srinivasa Vittal, McCowan, Colin, Murray, Josie, O’Leary, Maureen, Ritchie, Lewis D., Shah, Syed Ahmar, Simpson, Colin R., Robertson, Chris, Sheikh, Aziz, Stock, Sarah J., Wood, Rachael
Médium: Journal Article
Jazyk:angličtina
Vydáno: London Nature Publishing Group UK 17.10.2022
Nature Publishing Group
Nature Portfolio
Témata:
631/326/596/4130
692/308/174
692/699/255/2514
Abortion, Spontaneous - epidemiology
Cohort analysis
Cohort Studies
Coronaviruses
COVID-19
COVID-19 - epidemiology
COVID-19 - prevention & control
COVID-19 vaccines
COVID-19 Vaccines - adverse effects
Ectopic pregnancy
Electronic health records
Electronic medical records
Female
Gestation
Humanities and Social Sciences
Humans
Immunization
Influenza, Human - prevention & control
Miscarriage
multidisciplinary
Pandemics
Population studies
Population-based studies
Pregnancy
Pregnancy complications
Pregnancy Outcome
Pregnancy, Ectopic
Safety
SARS-CoV-2
Science
Science (multidisciplinary)
Severe acute respiratory syndrome coronavirus 2
Vaccination
Vaccines
Viral diseases
United Kingdom > UK
Scotland
ISSN:2041-1723, 2041-1723
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Shrnutí:Data on the safety of COVID-19 vaccines in early pregnancy are limited. We conducted a national, population-based, matched cohort study assessing associations between COVID-19 vaccination and miscarriage prior to 20 weeks gestation and, separately, ectopic pregnancy. We identified women in Scotland vaccinated between 6 weeks preconception and 19 weeks 6 days gestation (for miscarriage; n = 18,780) or 2 weeks 6 days gestation (for ectopic; n = 10,570). Matched, unvaccinated women from the pre-pandemic and, separately, pandemic periods were used as controls. Here we show no association between vaccination and miscarriage (adjusted Odds Ratio [aOR], pre-pandemic controls = 1.02, 95% Confidence Interval [CI] = 0.96–1.09) or ectopic pregnancy (aOR = 1.13, 95% CI = 0.92–1.38). We undertook additional analyses examining confirmed SARS-CoV-2 infection as the exposure and similarly found no association with miscarriage or ectopic pregnancy. Our findings support current recommendations that vaccination remains the safest way for pregnant women to protect themselves and their babies from COVID-19. Data on the safety of COVD-19 vaccines in early pregnancy are limited. Here, the authors assess the rates of miscarriage and ectopic pregnancy following vaccination using electronic health record data from Scotland, and find no evidence of increased risks.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:2041-1723
2041-1723
DOI:10.1038/s41467-022-33937-y