All disease begins in the (leaky) gut: role of zonulin-mediated gut permeability in the pathogenesis of some chronic inflammatory diseases [version 1; peer review: 3 approved]

Improved hygiene leading to reduced exposure to microorganisms has been implicated as one possible cause for the recent "epidemic" of chronic inflammatory diseases (CIDs) in industrialized countries. That is the essence of the hygiene hypothesis that argues that rising incidence of CIDs ma...

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Bibliographic Details
Published in:	F1000 research Vol. 9; p. 69
Main Author:	Fasano, Alessio
Format:	Journal Article
Language:	English
Published:	England Faculty of 1000 Ltd 2020 F1000 Research Limited F1000 Research Ltd
Subjects:	Antigens Cholera Toxin Digestive system Environmental changes Enzymes Epidemics Gastrointestinal Microbiome Gastrointestinal tract Genomes Genomics Haptoglobins Humans Hypotheses Immune response Immunological tolerance Infectious diseases Inflammatory diseases Intestinal microflora Intestinal Mucosa Intestine Kinases Microbiomes Microbiota Microorganisms Mucosa Mutation Pathogenesis Permeability Physiology Protein Precursors Proteins Proteomics Review Therapeutic applications Transgenic animals Tumor necrosis factor-TNF Gut permeability zonulin Chronic inflammatory diseases microbiome
ISSN:	2046-1402, 2046-1402
Online Access:	Get full text
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