The plasticity of DNA replication forks in response to clinically relevant genotoxic stress

Complete and accurate DNA replication requires the progression of replication forks through DNA damage, actively transcribed regions, structured DNA and compact chromatin. Recent studies have revealed a remarkable plasticity of the replication process in dealing with these obstacles, which includes...

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Bibliographic Details
Published in:	Nature reviews. Molecular cell biology Vol. 21; no. 10; pp. 633 - 651
Main Authors:	Berti, Matteo, Cortez, David, Lopes, Massimo
Format:	Journal Article
Language:	English
Published:	England Nature Publishing Group 01.10.2020
Subjects:	Adaptation Animals Barriers Carcinogenesis - genetics Chromatin Chromatin - genetics Crosstalk Deoxyribonucleic acid DNA DNA - genetics DNA biosynthesis DNA damage DNA Damage - genetics DNA Replication - genetics Functional morphology Genotoxicity Humans Immunity Immunity, Innate - genetics Innate immunity Plastic properties Plasticity Replication Replication forks Replication Origin - genetics Replication origins Structural damage Tumorigenesis
ISSN:	1471-0072, 1471-0080, 1471-0080
Online Access:	Get full text
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