Lysosomal sequestration of sunitinib: a novel mechanism of drug resistance

Resistance to antiangiogenic tyrosine kinase inhibitors such as sunitinib is an important clinical problem, but its underlying mechanisms are largely unknown. We analyzed tumor sunitinib levels in mice and patients and studied sensitivity and resistance mechanisms to sunitinib. Intratumoral and plas...

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Veröffentlicht in:	Clinical cancer research Jg. 17; H. 23; S. 7337
Hauptverfasser:	Gotink, Kristy J, Broxterman, Henk J, Labots, Mariette, de Haas, Richard R, Dekker, Henk, Honeywell, Richard J, Rudek, Michelle A, Beerepoot, Laurens V, Musters, René J, Jansen, Gerrit, Griffioen, Arjan W, Assaraf, Yehuda G, Pili, Roberto, Peters, Godefridus J, Verheul, Henk M W
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.12.2011
Schlagworte:	Angiogenesis Inhibitors - blood Angiogenesis Inhibitors - metabolism Angiogenesis Inhibitors - pharmacology Animals Carcinoma, Renal Cell - drug therapy Carcinoma, Renal Cell - metabolism Cell Line, Tumor Cell Proliferation - drug effects Drug Resistance, Neoplasm Female HCT116 Cells HT29 Cells Humans Indoles - blood Indoles - metabolism Indoles - pharmacology Kidney Neoplasms - drug therapy Kidney Neoplasms - metabolism Kidney Neoplasms - pathology Lysosomes - metabolism Mice Neoplasms - drug therapy Neoplasms - metabolism Neoplasms - pathology Protein-Tyrosine Kinases - antagonists & inhibitors Pyrroles - blood Pyrroles - metabolism Pyrroles - pharmacology
ISSN:	1078-0432, 1557-3265, 1557-3265
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