Epithelial-mesenchymal transition can suppress major attributes of human epithelial tumor-initiating cells

Malignant progression in cancer requires populations of tumor-initiating cells (TICs) endowed with unlimited self renewal, survival under stress, and establishment of distant metastases. Additionally, the acquisition of invasive properties driven by epithelial-mesenchymal transition (EMT) is critica...

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Bibliographic Details
Published in:	The Journal of clinical investigation Vol. 122; no. 5; pp. 1849 - 1868
Main Authors:	Celià-Terrassa, Toni, Meca-Cortés, Óscar, Mateo, Francesca, Martínez de Paz, Alexia, Rubio, Nuria, Arnal-Estapé, Anna, Ell, Brian J., Bermudo, Raquel, Díaz, Alba, Guerra-Rebollo, Marta, Lozano, Juan José, Estarás, Conchi, Ulloa, Catalina, ρlvarez-Simón, Daniel, Milà, Jordi, Vilella, Ramón, Paciucci, Rosanna, Martínez-Balbás, Marian, García de Herreros, Antonio, Gomis, Roger R., Kang, Yibin, Blanco, Jerónimo, Fernández, Pedro L., Thomson, Timothy M.
Format:	Journal Article
Language:	English
Published:	United States American Society for Clinical Investigation 01.05.2012
Subjects:	Animals Antigens, Differentiation - genetics Antigens, Differentiation - metabolism Antígens Biomedical research Bladder cancer Cadherins - genetics Cadherins - metabolism Cancer cells Cell Line, Tumor Cell Movement Cell Shape Coculture Techniques Cooperation Cèl·lules epitelials Epigenetics Epithelial Cells - pathology Epithelial Cells - physiology Epithelial tumors Epithelial-Mesenchymal Transition - genetics Factors de transcripció Gene Expression Profiling Gene Regulatory Networks Genes Homeodomain Proteins - genetics Homeodomain Proteins - metabolism Humans Male Metastasis Mice Mice, Inbred NOD Mice, SCID Mutation Neoplasm Invasiveness - pathology Neoplasm Metastasis - pathology Neoplasm Staging Neoplasm Transplantation Physiological aspects Prostate cancer Prostatic Neoplasms Proteïnes Repressor Proteins - genetics Repressor Proteins - metabolism Snail Family Transcription Factors Spheroids, Cellular - metabolism Spheroids, Cellular - pathology Stem cells Transcription Factors - genetics Transcription Factors - metabolism Tumors Twist-Related Protein 1 - genetics Twist-Related Protein 1 - metabolism Urinary Bladder Neoplasms Zinc Finger E-box-Binding Homeobox 1
ISSN:	0021-9738, 1558-8238, 1558-8238
Online Access:	Get full text
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